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Improving Working Memory in Older Adults by Restoring Large-Scale Cortical Interactions

通过恢复大规模皮层相互作用来改善老年人的工作记忆

基本信息

批准号：
10629187
负责人：
Robert Reinhart
金额：
$ 41.25万
依托单位：
BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-08-15 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10629187
关键词：
20 year old Adult Age Age-associated memory impairment Aging Alzheimer&apos s Disease Anatomy Architecture Area Basic Science Behavior Behavioral Brain Brain Diseases Cephalic Clinical Code Cognition Cognitive Coupled Coupling Data Data Collection Dementia Deterioration Development Double-Blind Method Elderly Electric Stimulation Electroencephalography Electrophysiology (science)Foundations Frequencies Goals Hour Human Impaired cognition Impairment Individual Individual Differences Intervention Knowledge Longevity Maintenance Measurement Measures Medial Mediating Memory impairment Methods Nature Neurocognitive Neurosciences Performance Periodicity Pharmaceutical Preparations Phase Physiological Population Prefrontal Cortex Prevalence Procedures Protocols documentation Reproducibility of Results Research Research Personnel Sample Size Scheme Short-Term Memory Source Specificity System Techniques Technology Temporal Lobe Testing age related age related neurodegeneration aged cognitive enhancement cognitive neuroscience cognitive performance density executive function experimental study flexibility frontal lobe healthy aging improved indexing information processing innovation insight interest neural neurophysiology neuroregulation next generation novel novel therapeutics power analysis programs reconstruction segregation statistics support network theories tool young adult

项目摘要

PROJECT SUMMARY/ABSTRACT Over the last century, we have witnessed an astonishing rise in the prevalence of cognitive decline and dementia in older adults 1-3, which is expected to grow even faster in coming years as the global population rapidly ages 3-5. For decades, deficits in working memory - the ability to hold behaviorally useful information “in mind” over a period of seconds - have characterized a central feature of the normal cognitive decline observed across the adult lifespan and the abnormal rapid cognitive deterioration associated with dementias, such as Alzheimer's disease 6-10. These facts motivate the need to advance greater understanding of the brain mechanisms underlying age-related working memory deficits, and develop effective methods to maintain or even improve cognitive performance in older adults 11-13. Here, we propose to examine the mechanisms of age-related working memory impairment in healthy humans from a physiologically inspired perspective centered on large-scale brain networks and how they interact through synchronized electrophysiological rhythms 14-18. We focus on neural coding schemes (i.e., cross-frequency coupling and phase synchronization) hypothesized to index flexible large-scale circuits that integrate information across multiple temporal and spatial scales during cognition. We combine high-density electroencephalographic (EEG) measurements of synchronized rhythms with individually customized high-definition transcranial alternating-current stimulation (HD-tACS) 19-21 to determine whether it is possible to modify components of frontotemporal networks and cause improvements in working memory performance for older adults. Our preliminary data are highly encouraging and indicate that we can causally manipulate the synchronization of long-range low-frequency rhythms, increase local phase-amplitude coupling, and rapidly improve working memory behavior in older adults aged 60-76 years to accuracy levels equivalent to those of 20-year-olds. The goals of the research program are to use novel neuroscience tools and analysis procedures to gain a deeper understanding of the brain mechanisms underlying age-related working memory impairment, and contribute new knowledge to the development of effective, non-pharmacological interventions for improving cognition in healthy aging and clinical populations.

项目总结/文摘