Improving Working Memory in Older Adults by Restoring Large-Scale Cortical Interactions
通过恢复大规模皮层相互作用来改善老年人的工作记忆
基本信息
- 批准号:10398130
- 负责人:
- 金额:$ 41.25万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-08-15 至 2024-04-30
- 项目状态:已结题
- 来源:
- 关键词:20 year oldAdultAgeAge-associated memory impairmentAgingAlzheimer&aposs DiseaseAnatomyArchitectureAreaBasic ScienceBehaviorBehavioralBrainBrain DiseasesClinicalCodeCognitionCognitiveCoupledCouplingCustomDataData CollectionDementiaDeteriorationDevelopmentDouble-Blind MethodElderlyElectric StimulationElectroencephalographyElectrophysiology (science)FoundationsFrequenciesGoalsHourHumanImpaired cognitionImpairmentIndividualIndividual DifferencesInterventionKnowledgeLeadLongevityMaintenanceMeasurementMeasuresMedialMediatingMemory impairmentMethodsMindNatureNeurocognitiveNeurosciencesPerformancePeriodicityPharmaceutical PreparationsPhasePhysiologicalPopulationPrefrontal CortexPrevalenceProceduresProtocols documentationReproducibility of ResultsResearchResearch PersonnelSample SizeSchemeShort-Term MemorySourceSpecificitySystemTechniquesTechnologyTemporal LobeTestingage relatedage related neurodegenerationagedbasecognitive enhancementcognitive neurosciencecognitive performancedensityexecutive functionexperimental studyflexibilityfrontal lobefunctional improvementhealthy agingimprovedindexinginformation processinginnovationinsightinterestneurophysiologyneuroregulationnext generationnovelnovel therapeuticspower analysisprogramsreconstructionrelating to nervous systemstatisticssupport networktheoriestoolyoung adult
项目摘要
PROJECT SUMMARY/ABSTRACT
Over the last century, we have witnessed an astonishing rise in the prevalence of cognitive decline and
dementia in older adults 1-3, which is expected to grow even faster in coming years as the global population
rapidly ages 3-5. For decades, deficits in working memory - the ability to hold behaviorally useful information “in
mind” over a period of seconds - have characterized a central feature of the normal cognitive decline observed
across the adult lifespan and the abnormal rapid cognitive deterioration associated with dementias, such as
Alzheimer's disease 6-10. These facts motivate the need to advance greater understanding of the brain
mechanisms underlying age-related working memory deficits, and develop effective methods to maintain or
even improve cognitive performance in older adults 11-13. Here, we propose to examine the mechanisms of
age-related working memory impairment in healthy humans from a physiologically inspired perspective
centered on large-scale brain networks and how they interact through synchronized electrophysiological
rhythms 14-18. We focus on neural coding schemes (i.e., cross-frequency coupling and phase synchronization)
hypothesized to index flexible large-scale circuits that integrate information across multiple temporal and
spatial scales during cognition. We combine high-density electroencephalographic (EEG) measurements of
synchronized rhythms with individually customized high-definition transcranial alternating-current stimulation
(HD-tACS) 19-21 to determine whether it is possible to modify components of frontotemporal networks and
cause improvements in working memory performance for older adults. Our preliminary data are highly
encouraging and indicate that we can causally manipulate the synchronization of long-range low-frequency
rhythms, increase local phase-amplitude coupling, and rapidly improve working memory behavior in older
adults aged 60-76 years to accuracy levels equivalent to those of 20-year-olds. The goals of the research
program are to use novel neuroscience tools and analysis procedures to gain a deeper understanding of the
brain mechanisms underlying age-related working memory impairment, and contribute new knowledge to the
development of effective, non-pharmacological interventions for improving cognition in healthy aging and
clinical populations.
项目总结/摘要
在上个世纪,我们目睹了认知能力下降的流行率惊人地上升,
1-3岁老年人痴呆症,随着全球人口的增长,
快速3-5岁。几十年来,工作记忆的缺陷-保持行为有用信息的能力“,
在几秒钟的时间内,“大脑”的功能已经成为观察到的正常认知能力下降的中心特征。
以及与痴呆症相关的异常快速认知衰退,如
老年痴呆症6-10.这些事实激发了对大脑更深入理解的需求
与年龄相关的工作记忆缺陷的潜在机制,并制定有效的方法来维持或
甚至可以改善11-13岁老年人的认知能力。在这里,我们建议检查的机制,
从生理学角度看健康人与年龄相关的工作记忆损伤
集中在大规模的大脑网络以及它们如何通过同步电生理学相互作用,
节奏14-18.我们专注于神经编码方案(即,交叉频率耦合和相位同步)
假设索引灵活的大规模电路,集成跨多个时间和
空间尺度的认知。我们结合联合收割机高密度脑电图(EEG)测量,
通过个性化定制的高清晰度经颅交流电刺激实现同步节律
(HD-tACS)19-21,以确定是否有可能修改额颞叶网络的组件,
导致老年人工作记忆能力的提高。我们的初步数据显示
令人鼓舞的,并表明我们可以因果操纵的同步远程低频
节奏,增加局部相位振幅耦合,并迅速改善老年人的工作记忆行为。
60-76岁的成年人的准确度水平相当于20岁的人。研究的目标
计划是使用新的神经科学工具和分析程序,以获得更深入的了解,
大脑机制潜在的年龄相关的工作记忆障碍,并贡献新的知识,
开发有效的非药物干预措施,以改善健康老龄化的认知能力,
临床人群。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Robert Reinhart其他文献
Robert Reinhart的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Robert Reinhart', 18)}}的其他基金
Personalized Synchronization of Cortical Rhythms to Improve Memory in Alzheimer's Disease
皮质节律的个性化同步可改善阿尔茨海默氏病的记忆力
- 批准号:
10709218 - 财政年份:2023
- 资助金额:
$ 41.25万 - 项目类别:
Improving Working Memory in Older Adults by Restoring Large-Scale Cortical Interactions
通过恢复大规模皮层相互作用来改善老年人的工作记忆
- 批准号:
9797165 - 财政年份:2019
- 资助金额:
$ 41.25万 - 项目类别:
Improving Working Memory in Older Adults by Restoring Large-Scale Cortical Interactions
通过恢复大规模皮层相互作用来改善老年人的工作记忆
- 批准号:
10165454 - 财政年份:2019
- 资助金额:
$ 41.25万 - 项目类别:
Improving Working Memory in Older Adults by Restoring Large-Scale Cortical Interactions
通过恢复大规模皮层相互作用来改善老年人的工作记忆
- 批准号:
10629187 - 财政年份:2019
- 资助金额:
$ 41.25万 - 项目类别:
Causal Restructuring of Neural Rhythms Improves Adaptive Behavior
神经节律的因果重组可改善适应性行为
- 批准号:
10299619 - 财政年份:2017
- 资助金额:
$ 41.25万 - 项目类别:
Causal Restructuring of Neural Rhythms Improves Adaptive Behavior
神经节律的因果重组可改善适应性行为
- 批准号:
10056221 - 财政年份:2017
- 资助金额:
$ 41.25万 - 项目类别:
Cognitive Control and its neural substrates in schizophrenia
精神分裂症的认知控制及其神经基础
- 批准号:
8925705 - 财政年份:2014
- 资助金额:
$ 41.25万 - 项目类别:
相似海外基金
Developing a Young Adult-Mediated Intervention to Increase Colorectal Cancer Screening among Rural Screening Age-Eligible Adults
制定年轻人介导的干预措施,以增加农村符合筛查年龄的成年人的结直肠癌筛查
- 批准号:
10653464 - 财政年份:2023
- 资助金额:
$ 41.25万 - 项目类别:
Doctoral Dissertation Research: Estimating adult age-at-death from the pelvis
博士论文研究:从骨盆估算成人死亡年龄
- 批准号:
2316108 - 财政年份:2023
- 资助金额:
$ 41.25万 - 项目类别:
Standard Grant
Determining age dependent factors driving COVID-19 disease severity using experimental human paediatric and adult models of SARS-CoV-2 infection
使用 SARS-CoV-2 感染的实验性人类儿童和成人模型确定导致 COVID-19 疾病严重程度的年龄依赖因素
- 批准号:
BB/V006738/1 - 财政年份:2020
- 资助金额:
$ 41.25万 - 项目类别:
Research Grant
Transplantation of Adult, Tissue-Specific RPE Stem Cells for Non-exudative Age-related macular degeneration (AMD)
成人组织特异性 RPE 干细胞移植治疗非渗出性年龄相关性黄斑变性 (AMD)
- 批准号:
10294664 - 财政年份:2020
- 资助金额:
$ 41.25万 - 项目类别:
Sex differences in the effect of age on episodic memory-related brain function across the adult lifespan
年龄对成人一生中情景记忆相关脑功能影响的性别差异
- 批准号:
422882 - 财政年份:2019
- 资助金额:
$ 41.25万 - 项目类别:
Operating Grants
Modelling Age- and Sex-related Changes in Gait Coordination Strategies in a Healthy Adult Population Using Principal Component Analysis
使用主成分分析对健康成年人群步态协调策略中与年龄和性别相关的变化进行建模
- 批准号:
430871 - 财政年份:2019
- 资助金额:
$ 41.25万 - 项目类别:
Studentship Programs
Transplantation of Adult, Tissue-Specific RPE Stem Cells as Therapy for Non-exudative Age-Related Macular Degeneration AMD
成人组织特异性 RPE 干细胞移植治疗非渗出性年龄相关性黄斑变性 AMD
- 批准号:
9811094 - 财政年份:2019
- 资助金额:
$ 41.25万 - 项目类别:
Study of pathogenic mechanism of age-dependent chromosome translocation in adult acute lymphoblastic leukemia
成人急性淋巴细胞白血病年龄依赖性染色体易位发病机制研究
- 批准号:
18K16103 - 财政年份:2018
- 资助金额:
$ 41.25万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Doctoral Dissertation Research: Literacy Effects on Language Acquisition and Sentence Processing in Adult L1 and School-Age Heritage Speakers of Spanish
博士论文研究:识字对西班牙语成人母语和学龄传统使用者语言习得和句子处理的影响
- 批准号:
1823881 - 财政年份:2018
- 资助金额:
$ 41.25万 - 项目类别:
Standard Grant
Adult Age-differences in Auditory Selective Attention: The Interplay of Norepinephrine and Rhythmic Neural Activity
成人听觉选择性注意的年龄差异:去甲肾上腺素与节律神经活动的相互作用
- 批准号:
369385245 - 财政年份:2017
- 资助金额:
$ 41.25万 - 项目类别:
Research Grants