Targeting neurogenesis-inhibition coupling to improve memory in aging\Diversity Supplement
靶向神经发生-抑制耦合以改善衰老多样性补充剂的记忆力
基本信息
- 批准号:10670533
- 负责人:
- 金额:$ 2.58万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-06-01 至 2027-03-31
- 项目状态:未结题
- 来源:
- 关键词:AdultAgeAge-associated memory impairmentAgingBehavioral ParadigmCognitiveCouplingDataDiscriminationEpisodic memoryGoalsHippocampusHumanHyperactivityInterneuronsMapsMemoryMemory impairmentMolecular ProfilingNeuronsParvalbuminsPlayPrefrontal CortexPublishingRodentRoleSiteTestingViraldentate gyrusexperiencegain of functiongenetic approachimprovedin vivomemory consolidationmemory processmild cognitive impairmentneural circuitneurogenesisneuronal excitabilitynonhuman primatenoveloptogeneticsrecruitresponsesocial
项目摘要
The hippocampus plays a critical role in the formation of episodic memories by generating distinct, conjunctive
representations of (spatial and social) experiences and transferring these representations to prefrontal cortical
sites for memory storage or consolidation. Age-related cognitive decline and mild-cognitive impairment (MCI)
are characterized by increased memory interference, decreased stability of memory representations and
inefficient memory consolidation. Evidence from humans, non-human primates and rodents demonstrate
reduced hippocampal neurogenesis, hippocampal hyperactivity and inflexible remapping during age- related
cognitive decline and MCI. Parvalbumin inhibitory interneurons (PV INs) play a pivotal role in memory
discrimination and consolidation by regulating neuronal excitability and synchronizing neuronal firing underlying
neuronal ensembles and sharp-wave ripples (SWRs). Thus, reduced PV IN recruitment in hippocampal CA2, a
hub for social memory processing, may contribute to age-associated social memory impairments. Here, we
propose a role for neurogenesis-inhibition coupling in the dentate gyrus-CA2 as a candidate circuit mechanism
by which adult-born neurons promote social memory consolidation in adulthood and aging. In response to the
FOA, we will develop and validate an in vivo gain-of-function platform for iterative testing of pro-cognitive
potential of novel candidate regulators of neurogenesis-inhibition coupling during aging. Towards this goal, we
will build on extensive preliminary and published data and integrate a genetic approach to enhance
neurogenesis, input-specific manipulation of PV INs, activity-dependent molecular profiling of PV INs, PV IN
targeted viral expression, optogenetics, ex vivo and in vivo local field potential recordings and an aging-
sensitive social memory behavioral paradigm. Together, these Aims will establish proof-of-concept for a novel
platform for targeting a neurogenesis-inhibition coupling mechanism to improve social memory in aging and
MCI.
海马体在情景记忆的形成中起着至关重要的作用
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Amar Sahay其他文献
Amar Sahay的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Amar Sahay', 18)}}的其他基金
Hippocampal synaptic and circuit mechanisms mediating Dyrk1a functions in social cognition
海马突触和回路机制介导 Dyrk1a 在社会认知中的功能
- 批准号:
10562383 - 财政年份:2023
- 资助金额:
$ 2.58万 - 项目类别:
Targeting neurogenesis-inhibition coupling to improve memory in aging
靶向神经发生-抑制耦合以改善衰老记忆
- 批准号:
10426470 - 财政年份:2022
- 资助金额:
$ 2.58万 - 项目类别:
Targeting neurogenesis-inhibition coupling to improve memory in aging
靶向神经发生-抑制耦合以改善衰老记忆
- 批准号:
10851086 - 财政年份:2022
- 资助金额:
$ 2.58万 - 项目类别:
Targeting neurogenesis-inhibition coupling to improve memory in aging
靶向神经发生-抑制耦合以改善衰老记忆
- 批准号:
10629324 - 财政年份:2022
- 资助金额:
$ 2.58万 - 项目类别:
Transcriptional Control of adult hippocampal neural stem cell homeostasis
成人海马神经干细胞稳态的转录控制
- 批准号:
10201930 - 财政年份:2020
- 资助金额:
$ 2.58万 - 项目类别:
Contributions of hippocampal oxytocin receptors to social recognition
海马催产素受体对社会认可的贡献
- 批准号:
10286210 - 财政年份:2017
- 资助金额:
$ 2.58万 - 项目类别:
Contributions of hippocampal oxytocin receptors to social recognition
海马催产素受体对社会认可的贡献
- 批准号:
10056173 - 财政年份:2017
- 资助金额:
$ 2.58万 - 项目类别:
Contributions of hippocampal oxytocin receptors to social recognition
海马催产素受体对社会认可的贡献
- 批准号:
10300447 - 财政年份:2017
- 资助金额:
$ 2.58万 - 项目类别:
Re-engineering excitation-inhibition connectivity to rejuvenate memory circuits in aging
重新设计兴奋-抑制连接以恢复衰老过程中的记忆电路
- 批准号:
9028637 - 财政年份:2016
- 资助金额:
$ 2.58万 - 项目类别:
Molecular control of excitation-inhibition balance to encode ambiguous threats
兴奋抑制平衡的分子控制来编码模糊的威胁
- 批准号:
9237311 - 财政年份:2014
- 资助金额:
$ 2.58万 - 项目类别:
相似国自然基金
靶向递送一氧化碳调控AGE-RAGE级联反应促进糖尿病创面愈合研究
- 批准号:JCZRQN202500010
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
对香豆酸抑制AGE-RAGE-Ang-1通路改善海马血管生成障碍发挥抗阿尔兹海默病作用
- 批准号:2025JJ70209
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
AGE-RAGE通路调控慢性胰腺炎纤维化进程的作用及分子机制
- 批准号:
- 批准年份:2024
- 资助金额:0 万元
- 项目类别:面上项目
甜茶抑制AGE-RAGE通路增强突触可塑性改善小鼠抑郁样行为
- 批准号:2023JJ50274
- 批准年份:2023
- 资助金额:0.0 万元
- 项目类别:省市级项目
蒙药额尔敦-乌日勒基础方调控AGE-RAGE信号通路改善术后认知功能障碍研究
- 批准号:
- 批准年份:2022
- 资助金额:33 万元
- 项目类别:地区科学基金项目
补肾健脾祛瘀方调控AGE/RAGE信号通路在再生障碍性贫血骨髓间充质干细胞功能受损的作用与机制研究
- 批准号:
- 批准年份:2022
- 资助金额:52 万元
- 项目类别:面上项目
LncRNA GAS5在2型糖尿病动脉粥样硬化中对AGE-RAGE 信号通路上相关基因的调控作用及机制研究
- 批准号:
- 批准年份:2022
- 资助金额:10.0 万元
- 项目类别:省市级项目
围绕GLP1-Arginine-AGE/RAGE轴构建探针组学方法探索大柴胡汤异病同治的效应机制
- 批准号:81973577
- 批准年份:2019
- 资助金额:55.0 万元
- 项目类别:面上项目
AGE/RAGE通路microRNA编码基因多态性与2型糖尿病并发冠心病的关联研究
- 批准号:81602908
- 批准年份:2016
- 资助金额:18.0 万元
- 项目类别:青年科学基金项目
高血糖激活滑膜AGE-RAGE-PKC轴致骨关节炎易感的机制研究
- 批准号:81501928
- 批准年份:2015
- 资助金额:18.0 万元
- 项目类别:青年科学基金项目
相似海外基金
THE GENETICS AND FUNCTIONAL NEUROANATOMY OF AGE-ASSOCIATED MEMORY IMPAIRMENT
年龄相关记忆障碍的遗传学和功能神经解剖学
- 批准号:
7606738 - 财政年份:2007
- 资助金额:
$ 2.58万 - 项目类别:
THE GENETICS AND FUNCTIONAL NEUROANATOMY OF AGE-ASSOCIATED MEMORY IMPAIRMENT
年龄相关记忆障碍的遗传学和功能神经解剖学
- 批准号:
7717960 - 财政年份:2007
- 资助金额:
$ 2.58万 - 项目类别:
THE GENETICS AND FUNCTIONAL NEUROANATOMY OF AGE-ASSOCIATED MEMORY IMPAIRMENT
年龄相关记忆障碍的遗传学和功能神经解剖学
- 批准号:
7205360 - 财政年份:2004
- 资助金额:
$ 2.58万 - 项目类别:
CITICOLINE AND AGE ASSOCIATED MEMORY IMPAIRMENT
胞二磷胆碱与年龄相关的记忆障碍
- 批准号:
6305687 - 财政年份:1999
- 资助金额:
$ 2.58万 - 项目类别:
CITICOLINE AND AGE ASSOCIATED MEMORY IMPAIRMENT
胞二磷胆碱与年龄相关的记忆障碍
- 批准号:
6115572 - 财政年份:1998
- 资助金额:
$ 2.58万 - 项目类别:
A study on the biological features of age-associated memory impairment (AAMI).
年龄相关记忆障碍(AAMI)生物学特征的研究。
- 批准号:
09671003 - 财政年份:1997
- 资助金额:
$ 2.58万 - 项目类别:
Grant-in-Aid for Scientific Research (C).
CITICOLINE AND AGE ASSOCIATED MEMORY IMPAIRMENT
胞二磷胆碱与年龄相关的记忆障碍
- 批准号:
6276806 - 财政年份:1997
- 资助金额:
$ 2.58万 - 项目类别:
AGE-ASSOCIATED MEMORY IMPAIRMENT: COMMUNITY-BASED STUDY
与年龄相关的记忆障碍:基于社区的研究
- 批准号:
3386469 - 财政年份:1990
- 资助金额:
$ 2.58万 - 项目类别:
AGE-ASSOCIATED MEMORY IMPAIRMENT: COMMUNITY-BASED STUDY
与年龄相关的记忆障碍:基于社区的研究
- 批准号:
3386468 - 财政年份:1990
- 资助金额:
$ 2.58万 - 项目类别:
AGE-ASSOCIATED MEMORY IMPAIRMENT: COMMUNITY-BASED STUDY
与年龄相关的记忆障碍:基于社区的研究
- 批准号:
2247160 - 财政年份:1990
- 资助金额:
$ 2.58万 - 项目类别:














{{item.name}}会员




