Child Health Research Center

项目摘要摘要 本续展申请(RFA-HD-18-011)用于支持儿童健康研究中心 (CHRC)在华盛顿大学医学院。儿科医生-科学家扮演着至关重要的角色 在促进知识以改善儿童健康方面的作用。为了满足持续不断的国家需求， 补充初级教师级别的儿科医生-科学家管道，我们的计划支持 每年指导3名学者的职业发展道路，为期2-3年，利用 华盛顿大学医学院和医学中心内的生物医学资源 校园里。正如我们在过去22年中所做的那样，我们中心的长期目标是发展 将研究重点放在儿科疾病导向生物学上的学者们 基础科学的进展，如发育生物学、细胞生物学、免疫学、 遗传学/基因组学和系统生物学。该提案的具体目标包括：1)保护 与知名研究人员一起指导的研究经验，涵盖了广泛的 华盛顿大学医学院和儿科系内的学科，2) 实验室管理、科学严谨性、统计学、资质等方面的必修课 和负责任的研究行为，3)基于学者的个性化的具体课程 研究领域(例如，生物信息学、活细胞成像)，4)对学者的持续反馈， 导师和CHRC领导层，以及5)促进女性学者和 代表不足的少数族裔。该项目现已有22年的历史，在 超过国家基准(“K12到K08/23”的转换率为63%和突出的“K到R” 转化率“分别为59%；全国平均水平和40%)，并最终将结束 基础科学家和儿科临床医生之间的知识差距。加里·A·西尔弗曼医学博士威尔 担任项目总监，医学博士David Hunstad将担任培训总监。中国红十字会和 它的学者将继续利用我们的机构资助的最先进的核心设施，为 例如，全基因组/外显子DNA测序、生物信息学、冷冻-EM成像、基因组编辑 和模型动物开发，以促进儿科疾病状态的研究。长期目标 正在实现，因为它的学者为我们对人类的理解做出了贡献 未来几十年的发育性疾病，同时演变为下一代科学 未来几代儿科学者的领袖、榜样和导师。

Project Summary Abstract This renewal application (RFA-HD-18-011) is for support of the Child Health Research Center (CHRC) at Washington University School of Medicine. Pediatric physician-scientists play a crucial role in advancing knowledge that improves child health. To meet the ongoing national need to replenish the pediatric physician-scientist pipeline at the junior faculty level, our program supports a mentored career development pathway for 3 Scholars per year for 2-3 years by leveraging a wealth of biomedical resources within the Washington University School of Medicine and the Medical Center campus. As we have done for the past 22 years, the long-term objective of our Center is to develop Scholars that focus their research efforts on Pediatric disease-oriented biology by applying recent advances in the basic sciences, such as developmental biology, cell biology, immunology, genetics/genomics, and systems biology. The specific aims of this proposal include: 1) protected mentored research experiences with well-established investigators encompassing a wide range of disciplines within the Washington University School of Medicine and the Department of Pediatrics, 2) obligatory educational programs in laboratory management, scientific rigor, statistics, grantsmanship and responsible conduct of research, 3) individualized specific coursework based on the Scholars’ areas of investigation (e.g., bioinformatics, live-cell imaging), 4) continuous feedback to the Scholars, mentors and CHRC leadership, and 5) foster the development of Scholars who are women and underrepresented minorities. The program, now twenty-two years old, has a stellar track record by exceeding national benchmarks (”K12 to K08/23” conversion rate of 63% and an outstanding “K to R conversion” rate of 59%; national average <40%, respectively), and will ultimately close the knowledge gap between basic scientists and pediatric clinicians. Gary A. Silverman, M.D., Ph.D. will serve as Program Director, and David Hunstad, M.D. will serve as Training Director. The CHRC and its Scholars will continue to utilize our institutionally-funded state-of-art core facilities that provide, for example, whole genome/exome DNA sequencing, bioinformatics, cryo-EM imaging, genome editing and model animal development, to facilitate the study of Pediatric disease states. The long-term goals of the CHRC are being realized as its Scholars contribute to our understanding of human developmental diseases for decades to come, while evolving into the next generation of scientific leaders, role models and mentors for subsequent generations of Pediatric Scholars.