Child Health Research Center

儿童健康研究中心

• 批准号: 10598355
• 负责人: GARY ARTHUR SILVERMAN
• 金额: $ 44.45万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-03-01 至 2027-11-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10598355
• 关键词: Area; Basic Science; Benchmarking; Bioinformatics; Biology; Cellular biology; Child Health; Child Support; Childhood; Clustered Regularly Interspaced Short Palindromic Repeats; Communities; Core Facility; Cryoelectron Microscopy; Development; Developmental Biology; Discipline; Disease; Doctor of Philosophy; Education; Faculty; Feedback; Generations; Genetic; Genomics; Goals; Image; Immunology; Institution; Investigation; Knowledge; Laboratories; Leadership; Mass Spectrum Analysis; Medicine; Mentored Clinical Scientist Development Program; Mentors; Pathway interactions; Physicians; Play; Research; Research Personnel; Role; Science; Scientist; Systems Biology; Training; Universities; Washington; Woman; animal model development; biomedical resource; career development; experience; genome editing; improved; medical schools; metabolomics; metagenomic sequencing; next generation; pediatric department; programs; responsible research conduct; role model; statistics; transcriptomics

PROJECT SUMMARY/ABSTRACT This renewal application (RFA-HD-21-017) is for support of the Child Health Research Center (CHRC) at Washington University School of Medicine. Pediatric physician-scientists play a crucial role in advancing knowledge that improves child health. To meet the ongoing national need to replenish the pediatric physician- scientist pipeline at the junior faculty level, our program supports a mentored career development pathway for 3 Scholars per year for 2-3 years by leveraging a wealth of biomedical resources across the Washington University School of Medicine campus. As we have done for the past 26 years, the long-term objective of our Center is to develop Scholars who focus their research efforts on pediatric disease-oriented biology by applying recent advances in the basic sciences, including developmental biology, cell biology, immunology, genetics/genomics, and systems biology. The specific aims of this proposal include: (1) providing protected, mentored research experiences with well-established investigators encompassing a wide range of disciplines across Washington University School of Medicine and within the Department of Pediatrics; (2) obligatory educational programs in laboratory management, scientific rigor, statistics, grantsmanship and responsible conduct of research; (3) personalized coursework based on each Scholar’s area of investigation (e.g., bioinformatics, statistics, advanced imaging); (4) ongoing feedback to the Scholars, mentors and CHRC leadership; and (5) promoting the development of Scholars who are women and are from communities traditionally underrepresented in medicine and science. The program has a stellar track record, by far exceeding national benchmarks (”K12 to K08/23” conversion rate of 73% and an outstanding “K to R conversion” rate of 60%; national average <38%), and will ultimately close the knowledge gap between basic scientists and pediatric clinicians. Gary A. Silverman, MD, PhD, will continue to serve as Program Director, and David Hunstad, MD, will continue to serve as Training Director. The CHRC and its Scholars will utilize dozens of institutional state-of-the-art core facilities that provide, for example, genomic and metagenomic sequencing, transcriptomics, metabolomics, mass spectrometry, bioinformatics, cryo-EM and other advanced imaging, CRISPR genome editing and animal model development, to facilitate the study of pediatric disease states. The long-term goals of the CHRC are being realized as its Scholars contribute to our understanding of child health and disease for decades to come, while evolving into the next generation of scientific leaders, role models, and mentors for subsequent generations of pediatric physician-scientists.

项目概要/摘要 此续订申请 (RFA-HD-21-017) 旨在支持儿童健康研究中心 (CHRC) 在华盛顿大学医学院。儿科医师科学家在推动儿科医学发展方面发挥着至关重要的作用 改善儿童健康的知识。为了满足国家对补充儿科医师的持续需求—— 在初级教师级别的科学家管道中，我们的计划支持有指导的职业发展道路 通过利用华盛顿州丰富的生物医学资源，每年 3 名学者，为期 2-3 年 大学医学院校园。正如我们过去 26 年所做的那样，我们的长期目标 中心旨在培养专注于儿科疾病生物学研究的学者 应用基础科学的最新进展，包括发育生物学、细胞生物学、免疫学、 遗传学/基因组学和系统生物学。该提案的具体目标包括：(1) 提供受保护的、 与涵盖广泛学科的知名研究人员一起指导研究经验 华盛顿大学医学院和儿科部门； (2) 强制性 实验室管理、科学严谨性、统计、资助和负责任的教育计划 进行研究； (3) 基于每位学者的研究领域的个性化课程（例如， 生物信息学、统计学、高级成像）； (4) 持续向学者、导师和 CHRC 提供反馈 领导; (5) 促进来自社区的女性学者的发展 传统上在医学和科学领域代表性不足。到目前为止，该计划拥有出色的记录 超过国家基准（“K12 to K08/23”转化率达73%，“K to R”表现出色） 转化率达到 60%；全国平均水平<38%），最终将缩小基础知识之间的差距 科学家和儿科临床医生。加里·A·西尔弗曼 (Gary A. Silverman) 医学博士、哲学博士将继续担任项目总监，并且 David Hunstad 医学博士将继续担任培训总监。 CHRC 及其学者将利用数十名 机构最先进的核心设施，例如提供基因组和宏基因组测序， 转录组学、代谢组学、质谱、生物信息学、冷冻电镜和其他先进成像， CRISPR 基因组编辑和动物模型开发，以促进儿科疾病状态的研究。这 随着其学者为我们对儿童健康的理解做出贡献，CHRC 的长期目标正在实现 和未来几十年的疾病，同时发展成为下一代科学领导者、榜样和 后代儿科医师科学家的导师。