Child Health Research Center

项目摘要/摘要 本续期申请(RFA-HD-21-017)用于支持儿童健康研究中心(CHRC) 在华盛顿大学医学院。儿科医生-科学家在推动 改善儿童健康的知识。为了满足国家对儿科医生补充的持续需求- 在初级教师级别的科学家管道，我们的计划支持有指导的职业发展道路 每年3名学者，为期2-3年，利用华盛顿地区丰富的生物医学资源 大学医学院校区。正如我们在过去26年所做的那样，我们的长期目标是 中心的目标是培养专注于儿科疾病生物学研究的学者 应用基础科学的最新进展，包括发育生物学、细胞生物学、免疫学、 遗传学/基因组学和系统生物学。这项建议的具体目标包括：(1)提供保护， 与涵盖广泛学科的知名研究人员一起指导研究经验 在华盛顿大学医学院和儿科系内；(2)必修 实验室管理、科学严谨性、统计学、资质和责任感方面的教育方案 进行研究；(3)基于每个学者的研究领域的个性化课程作业(例如， 生物信息学、统计学、高级成像)；(4)对学者、导师和CHRC的持续反馈 领导；和(5)促进妇女学者和社区学者的发展 传统上在医学和科学界的代表性不足。到目前为止，该项目有着出色的记录 超过国家基准(“K12至K08/23”的转换率为73%，以及突出的“K至R”转换率 转化率为60%；全国平均水平为38%)，并将最终缩小基础知识之间的差距 科学家和儿科临床医生。Gary A.Silverman，医学博士，博士，将继续担任项目主任，并 医学博士David Hunstad将继续担任培训主任。中国红十字会及其学者将利用数十个 例如，提供基因组和元基因组测序的机构最先进的核心设施， 转录学、代谢组学、质谱学、生物信息学、冷冻-EM等先进成像技术， CRISPR基因组编辑和动物模型开发，以促进儿科疾病状态的研究。这个 CHRC的长期目标正在实现，其学者为我们了解儿童健康做出了贡献 和疾病，同时演变为下一代科学领袖、榜样和 未来几代儿科内科医生-科学家的导师。

PROJECT SUMMARY/ABSTRACT This renewal application (RFA-HD-21-017) is for support of the Child Health Research Center (CHRC) at Washington University School of Medicine. Pediatric physician-scientists play a crucial role in advancing knowledge that improves child health. To meet the ongoing national need to replenish the pediatric physician- scientist pipeline at the junior faculty level, our program supports a mentored career development pathway for 3 Scholars per year for 2-3 years by leveraging a wealth of biomedical resources across the Washington University School of Medicine campus. As we have done for the past 26 years, the long-term objective of our Center is to develop Scholars who focus their research efforts on pediatric disease-oriented biology by applying recent advances in the basic sciences, including developmental biology, cell biology, immunology, genetics/genomics, and systems biology. The specific aims of this proposal include: (1) providing protected, mentored research experiences with well-established investigators encompassing a wide range of disciplines across Washington University School of Medicine and within the Department of Pediatrics; (2) obligatory educational programs in laboratory management, scientific rigor, statistics, grantsmanship and responsible conduct of research; (3) personalized coursework based on each Scholar’s area of investigation (e.g., bioinformatics, statistics, advanced imaging); (4) ongoing feedback to the Scholars, mentors and CHRC leadership; and (5) promoting the development of Scholars who are women and are from communities traditionally underrepresented in medicine and science. The program has a stellar track record, by far exceeding national benchmarks (”K12 to K08/23” conversion rate of 73% and an outstanding “K to R conversion” rate of 60%; national average <38%), and will ultimately close the knowledge gap between basic scientists and pediatric clinicians. Gary A. Silverman, MD, PhD, will continue to serve as Program Director, and David Hunstad, MD, will continue to serve as Training Director. The CHRC and its Scholars will utilize dozens of institutional state-of-the-art core facilities that provide, for example, genomic and metagenomic sequencing, transcriptomics, metabolomics, mass spectrometry, bioinformatics, cryo-EM and other advanced imaging, CRISPR genome editing and animal model development, to facilitate the study of pediatric disease states. The long-term goals of the CHRC are being realized as its Scholars contribute to our understanding of child health and disease for decades to come, while evolving into the next generation of scientific leaders, role models, and mentors for subsequent generations of pediatric physician-scientists.