Milk Analytics Core
牛奶分析核心
基本信息
- 批准号:10309713
- 负责人:
- 金额:$ 20.51万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-09-10 至 2026-07-31
- 项目状态:未结题
- 来源:
- 关键词:AliquotAnalytical ChemistryAntibiotic TherapyAntibioticsBiologicalBiological AssayBiomedical ResearchBreast FeedingBreastfed infantCaliforniaCellsChildhoodClinicalClinical DataClinical SciencesCollaborationsCollectionCommunitiesComplexCoupledDataData ScienceDetectionFluorescenceGoalsGrowth FactorHigh Pressure Liquid ChromatographyHormonesHuman CharacteristicsHuman MilkImmunoassayInfantInfant DevelopmentInfant HealthInfant MortalityKnowledgeLactationLactoseLeukocyte L1 Antigen ComplexLipidsMacronutrients NutritionMaternal and Child HealthMeasurementMeasuresMicrobeMicronutrientsMilkMothersMusMutationNear-Infrared SpectroscopyOligosaccharidesOutcomeParticipantPeptide HydrolasesPeptidesPerformancePregnancyProteinsProtocols documentationResearchResearch PersonnelResearch Project GrantsResourcesRiskRoleSafetySamplingServicesShipsTechnologyTherapeuticTherapeutic AgentsTherapeutic Human ExperimentationTriad Acrylic ResinUniversitiesValidationWomananalytical toolassay developmentbiological heterogeneitycytokinedesignexperiencefeedingghrelinglucagon-like peptide 1improvedinfant morbiditylipidomicsmacromoleculemetabolomicsmicrobiomemicrobiome analysismilk fat globulemilk microbiomeoperationpharmacometricsprogramsresponsesample collectionskills
项目摘要
ABSTRACT
The University of California San Diego (UC San Diego) MPRINT Center of Excellence in Therapeutics (CET)
involves a human milk (HM)-centered approach to investigate the role of maternal and pediatric therapeutics at
intersections of the mother-milk-infant ‘triad’. Key among the overall goals of the MPRINT CET are to assess
how maternal antibiotics impact HM composition and how HM components alter safety and efficacy of these
important pediatric therapeutic agents. HM composition analysis, however, is not trivial. HM composition is highly
dynamic and changes throughout lactation, indeed even throughout the course of a single feeding. HM is a
complex matrix that includes cells and microbes as well as large molecule aggregates like the milk fat globule.
HM also contains a unique set of molecules, the human milk oligosaccharides (HMOs), which represent the third
most abundant component of HM after lactose and lipids. Thus, the dynamic, complex, and unique nature of HM
requires specific collection protocols, assay development, and assay validation. With over 20 years of experience
in HM research, the Milk Analytics Core (MAC) will provide overall guidance and advice to MPRINT CET
investigators and staff. MAC will provide HM collection protocols and ready-to-ship sample collection kits to the
Clinical and Data Science Projects (Aim 1a) and receive HM samples for composition analysis (Aim 1b).
Depending on project needs, MAC offers macronutrient, oligosaccharide, and bioactive measurements as well
as milk microbiome analysis, the latter in collaboration with the UC San Diego Microbiome Core, which operates
independently of, but frequently in partnership with, our team. MAC will also provide mouse milk oligosaccharide
and microbiome analyses to the Research Project team (Aim 1c), applying our detailed prior knowledge of how
the St3gal4 mutation under study markedly depletes sialylated milk oligosaccharide content. Data generated
from our analyses will be returned to the respective project teams for integration. Separate HM aliquots from the
same samples will be passed directly on to the Pharmacometrics and Analytical Chemistry Core for antibiotic
drug quantification, and that data will likewise be directly returned to the respective project teams. In addition to
already established services, MAC will develop and validate new HM-specific assays by expanding the analyte
portfolio of the existing multiplex immunoassay platform (Aim 2a) and by engaging and activating other UC San
Diego researchers to apply and validate their unique technologies to HM research (Aim 2b). We envision MAC
to become a comprehensive milk analytics core with knowledge, skills, and technology, serving as a resource to
this and other MPRINT CETs and the biomedical research community at large. Together, we will be able to
generate a better understanding how antibiotic treatment during pregnancy and lactation impacts the mother-
milk-infant ‘triad’, inform and adjust precision in therapeutics, and ultimately improve maternal-child health.
摘要
加州圣地亚哥大学(UC San Diego)MPRINT治疗学卓越中心(CET)
涉及以母乳(HM)为中心的方法,以研究孕产妇和儿科治疗在
母亲-牛奶-婴儿“三元组”的交叉点。MPRINT CET的总体目标中的关键是评估
母体抗生素如何影响HM成分以及HM成分如何改变这些抗生素的安全性和有效性
重要的儿科治疗药物。然而,HM成分分析并不简单。HM成分高度
在整个哺乳期,甚至在一次喂养过程中,都是动态的和变化的。HM是一个
复杂的基质,包括细胞和微生物以及大分子聚集体,如乳脂球。
人乳还含有一组独特的分子,即人乳低聚糖(HMO),
人乳中含量仅次于乳糖和脂质的成分。因此,HM的动态、复杂和独特的性质
需要特定的采集方案、检测开发和检测验证。拥有超过20年的经验
在母乳研究中,牛奶分析核心(MAC)将为MPRINT CET提供全面的指导和建议
调查员和工作人员。MAC将提供HM采集协议和准备装运的样本采集套件,
临床和数据科学项目(目标1a),并接收人乳样品进行成分分析(目标1b)。
根据项目需要,MAC还提供常量营养素、低聚糖和生物活性测量
作为牛奶微生物组分析,后者与加州大学圣地亚哥分校微生物组核心合作,
独立于我们的团队,但经常与我们的团队合作。MAC还将提供鼠乳低聚糖
和微生物组分析的研究项目团队(目标1c),应用我们详细的先验知识,
所研究St 3gal 4突变显著地消耗唾液酸化乳低聚糖含量。生成的数据
我们的分析将返回给各自的项目团队进行整合。将HM等分试样与
相同的样本将直接传递给抗生素的药物计量学和分析化学核心
这些数据也将直接返回给各自的项目小组。除了
已经建立的服务,MAC将开发和验证新的HM特异性测定,通过扩大分析物
现有多重免疫分析平台(Aim 2a)的组合,并通过参与和激活其他UC San
迭戈研究人员将其独特的技术应用于HM研究并进行验证(目标2b)。我们设想MAC
成为一个拥有知识、技能和技术的综合牛奶分析核心,
这和其他MPRINT CET和整个生物医学研究界。团结起来,我们将能够
更好地了解怀孕和哺乳期间的抗生素治疗如何影响母亲-
母乳-婴儿“三合一”,告知和调整治疗的精确性,并最终改善母婴健康。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Lars Bode其他文献
Lars Bode的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Lars Bode', 18)}}的其他基金
Origins and Benefits of Biologically Active Components in Human Milk
母乳中生物活性成分的来源和益处
- 批准号:
10683486 - 财政年份:2023
- 资助金额:
$ 20.51万 - 项目类别:
Optimization of Antibiotics in Mothers and their Breastfed Infants Using Pharmacomicrobiomic and Metabolomic Analyses
利用药物微生物组学和代谢组学分析优化母亲及其母乳喂养婴儿的抗生素
- 批准号:
10681290 - 财政年份:2021
- 资助金额:
$ 20.51万 - 项目类别:
Exploring Associations between Human Milk Oligosaccharides and Atherosclerosis Risk Factors in Infancy and Early Childhood
探索母乳低聚糖与婴儿期和幼儿期动脉粥样硬化危险因素之间的关联
- 批准号:
10195374 - 财政年份:2021
- 资助金额:
$ 20.51万 - 项目类别:
Exploring Associations between Human Milk Oligosaccharides and Atherosclerosis Risk Factors in Infancy and Early Childhood
探索母乳低聚糖与婴儿期和幼儿期动脉粥样硬化危险因素之间的关联
- 批准号:
10491367 - 财政年份:2021
- 资助金额:
$ 20.51万 - 项目类别:
Optimization of Antibiotics in Mothers and their Breastfed Infants Using Pharmacomicrobiomic and Metabolomic Analyses
利用药物微生物组学和代谢组学分析优化母亲及其母乳喂养婴儿的抗生素
- 批准号:
10659295 - 财政年份:2021
- 资助金额:
$ 20.51万 - 项目类别:
Optimization of Antibiotics in Mothers and their Breastfed Infants Using Pharmacomicrobiomic and Metabolomic Analyses
利用药物微生物组学和代谢组学分析优化母亲及其母乳喂养婴儿的抗生素
- 批准号:
10309708 - 财政年份:2021
- 资助金额:
$ 20.51万 - 项目类别:
Optimization of Antibiotics in Mothers and their Breastfed Infants Using Pharmacomicrobiomic and Metabolomic Analyses
利用药物微生物组学和代谢组学分析优化母亲及其母乳喂养婴儿的抗生素
- 批准号:
10487493 - 财政年份:2021
- 资助金额:
$ 20.51万 - 项目类别:
Exploring human milk oligosaccharides and malaria risk in breastfed infants
探索母乳低聚糖和母乳喂养婴儿的疟疾风险
- 批准号:
10226366 - 财政年份:2020
- 资助金额:
$ 20.51万 - 项目类别:
相似海外基金
Aquatic Analytical Chemistry
水生分析化学
- 批准号:
CRC-2018-00279 - 财政年份:2022
- 资助金额:
$ 20.51万 - 项目类别:
Canada Research Chairs
Spatially Resolved Analytical Chemistry: Magnetic Resonance and Magnetic Resonance Imaging of Materials and Processes.
空间分辨分析化学:材料和过程的磁共振和磁共振成像。
- 批准号:
RGPIN-2022-04003 - 财政年份:2022
- 资助金额:
$ 20.51万 - 项目类别:
Discovery Grants Program - Individual
Analytical Chemistry of Proteins and Peptides
蛋白质和肽的分析化学
- 批准号:
RGPIN-2020-04677 - 财政年份:2022
- 资助金额:
$ 20.51万 - 项目类别:
Discovery Grants Program - Individual
Spatially Resolved Analytical Chemistry - Magnetic Resonance Imaging of Materials
空间分辨分析化学 - 材料的磁共振成像
- 批准号:
RGPIN-2015-06122 - 财政年份:2021
- 资助金额:
$ 20.51万 - 项目类别:
Discovery Grants Program - Individual
Aquatic Analytical Chemistry
水生分析化学
- 批准号:
CRC-2018-00279 - 财政年份:2021
- 资助金额:
$ 20.51万 - 项目类别:
Canada Research Chairs
Droplet-Based Analytical Chemistry Platforms Using Superhydrophobic and Superamphiphobic Surfaces
使用超疏水和超双疏表面的基于液滴的分析化学平台
- 批准号:
RGPIN-2016-04790 - 财政年份:2021
- 资助金额:
$ 20.51万 - 项目类别:
Discovery Grants Program - Individual
Analytical Chemistry of Proteins and Peptides
蛋白质和肽的分析化学
- 批准号:
RGPIN-2020-04677 - 财政年份:2021
- 资助金额:
$ 20.51万 - 项目类别:
Discovery Grants Program - Individual














{{item.name}}会员




