FASEB's Transcription, Chromatin and Epigenetics in Aging Conference

FASEB 衰老会议中的转录、染色质和表观遗传学

• 批准号: 10312653
• 负责人: ANNE BRUNET
• 金额: $ 5万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10312653
• 关键词: 3-Dimensional; Address; Age; Aging; Amaze; Animal Model; Area; Biological Models; Cell Aging; Cell physiology; Cells; Chromatin; Chromatin Structure; Collaborations; DNA; Development; Discipline; Disease; Educational workshop; Epigenetic Process; Event; Explosion; Fostering; Funding; Future; Gap Junctions; Gender; Genetic Transcription; Genome; Goals; Health; Human; Individual; International; Intervention; Italy; Knowledge; Learning; Malignant Neoplasms; Measures; Methodology; Microscopy; Molecular; Physicians; Play; Post-Translational Protein Processing; RNA; Regulation; Rejuvenation; Research; Research Personnel; Resolution; Role; Science; Scientist; Sicily; Technology; Therapeutic; Time; Transcriptional Regulation; Translating; Underrepresented Populations; Work; age related; anti aging; career development; chromatin modification; epigenetic regulation; epigenomics; frontier; grasp; histone modification; human disease; improved; innovation; insight; interdisciplinary collaboration; interest; meetings; normal aging; novel; novel therapeutic intervention; posters; regenerative cell; single cell technology; single molecule; symposium; tool

SUMMARY The goal of this FASEB meeting “Transcription, Chromatin and Epigenetics in Aging” is to cover the role new epigenetic mechanisms in the regulation of aging and in ‘rejuvenation’ strategies for age-related diseases. Epigenetic mechanisms encompass post-translational modifications of chromatin and RNA as well as transcriptional regulation. This FASEB meeting will be unique in integrating the latest discoveries in epigenetics and their importance in aging and ‘rejuvenation’ strategies for age-related diseases. There is a vital need for such a meeting. Exciting recent studies have revealed how organismal and cellular aging can be regulated by epigenetic mechanisms. The field of epigenetic is rapidly expanding, and the aging field needs to benefit from the latest and greatest discoveries in this area. Conversely, challenges and questions about the role of epigenetics in aging and age-related diseases abound, and it is critical for researchers in the chromatin and transcription fields to better grasp the implications of their work for health and disease. This FASEB meeting will discuss the most cutting-edge questions in field of chromatin, transcription, and epigenetics. A key topic will be the underlying molecular basis of epigenetic mechanisms. The question of how these mechanisms get dysregulated during normal aging and disease will also be discussed. The meeting will also cover new frontiers, including the exciting emerging field of three-dimensional chromatin structure and RNA epigenomics. The meeting will particularly focus on transformative epigenomic technologies at the single cell and single molecule levels and how they can be used to build and use ‘epigenetic clocks’ in cells from individuals at different ages and to identify novel ‘rejuvenation’ strategies for different age-related diseases. This meeting should foster exciting fundamental knowledge and information, new methodology and technical capabilities, and interdisciplinary collaborations. The meeting will also provide a uniquely interactive, diverse, and inclusive forum for trainees and new investigators in very different areas, highlighting their research through short talks, poster teasers and sessions and promoting several networking and meet-the-expert events.

概括 本次 FASEB 会议“衰老中的转录、染色质和表观遗传学”的目标是涵盖 新的表观遗传机制在衰老调节和“返老还童”策略中的作用 与年龄有关的疾病。表观遗传机制包括翻译后修饰 染色质和 RNA 以及转录调控。这次 FASEB 会议将是独一无二的 整合表观遗传学的最新发现及其在衰老和“返老还童”中的重要性 与年龄相关的疾病的策略。召开这样的会议非常有必要。最近激动人心 研究揭示了表观遗传如何调节有机体和细胞的衰老 机制。表观遗传学领域快速拓展，老龄化领域需受益 来自该领域最新和最伟大的发现。相反，挑战和问题 表观遗传学在衰老和与年龄相关的疾病中的作用比比皆是，对研究人员来说至关重要 在染色质和转录领域更好地掌握他们的工作对健康的影响 和疾病。 本次FASEB会议将讨论染色质领域最前沿的问题， 转录和表观遗传学。一个关键主题将是表观遗传的潜在分子基础 机制。这些机制在正常衰老过程中如何失调的问题 疾病也将被讨论。会议还将涵盖新领域，包括令人兴奋的 三维染色质结构和RNA表观基因组学的新兴领域。会议将 特别关注单细胞和单分子的变革性表观基因组技术 水平以及如何使用它们在来自个体的细胞中构建和使用“表观遗传时钟” 不同年龄，并针对不同年龄相关疾病确定新的“返老还童”策略。 这次会议应该培养令人兴奋的基础知识和信息、新方法 和技术能力以及跨学科合作。会议还将提供 为学员和新研究者提供独特的互动、多元化和包容性论坛 不同的领域，通过简短的演讲、海报预告片和会议来强调他们的研究， 促进多项网络和专家会面活动。