FASEB's Transcription, Chromatin and Epigenetics in Aging Conference

摘要 本次FASE B会议“衰老中的转录、染色质和表观遗传学”的目标是涵盖 新的表观遗传机制在衰老调节和“返老还童”策略中的作用 与年龄有关的疾病。表观遗传机制包括翻译后修饰 染色质和RNA以及转录调控。这次FASEB会议将是独一无二的 整合表观遗传学的最新发现及其在衰老和返老还童中的重要性 针对与年龄相关的疾病的战略。召开这样一次会议是非常必要的。令人兴奋的最近 研究揭示了生物和细胞衰老如何通过表观遗传来调节 机械装置。表观遗传领域迅速扩大，老龄化领域需要受益 来自这一地区最新和最伟大的发现。相反，挑战和问题涉及 表观遗传学在衰老和年龄相关疾病中的作用比比皆是，这对研究人员来说是至关重要的 在染色质和转录领域，以更好地理解他们的工作对健康的影响 和疾病。 本次FASEB会议将讨论染色质领域最前沿的问题， 转录和表观遗传学。一个关键话题将是表观遗传学的潜在分子基础 机械装置。这些机制是如何在正常衰老和 疾病也将被讨论。会议还将讨论新的领域，包括令人兴奋的 染色质三维结构和RNA表观基因组学的新兴领域。会议将于 特别关注单细胞和单分子的变革性表观基因组技术 水平，以及如何利用它们在来自个人的细胞中建立和使用“表观遗传时钟”。 为不同年龄的疾病确定新的“返老还童”策略。 这次会议应该促进令人振奋的基础知识和信息，新的方法 和技术能力，以及跨学科协作。会议还将提供一个 为受训人员和新调查人员提供独特的互动、多样化和包容性论坛 不同领域，通过简短的演讲、海报预告片和会议突出他们的研究 推广几个网络和专家见面会活动。

SUMMARY The goal of this FASEB meeting “Transcription, Chromatin and Epigenetics in Aging” is to cover the role new epigenetic mechanisms in the regulation of aging and in ‘rejuvenation’ strategies for age-related diseases. Epigenetic mechanisms encompass post-translational modifications of chromatin and RNA as well as transcriptional regulation. This FASEB meeting will be unique in integrating the latest discoveries in epigenetics and their importance in aging and ‘rejuvenation’ strategies for age-related diseases. There is a vital need for such a meeting. Exciting recent studies have revealed how organismal and cellular aging can be regulated by epigenetic mechanisms. The field of epigenetic is rapidly expanding, and the aging field needs to benefit from the latest and greatest discoveries in this area. Conversely, challenges and questions about the role of epigenetics in aging and age-related diseases abound, and it is critical for researchers in the chromatin and transcription fields to better grasp the implications of their work for health and disease. This FASEB meeting will discuss the most cutting-edge questions in field of chromatin, transcription, and epigenetics. A key topic will be the underlying molecular basis of epigenetic mechanisms. The question of how these mechanisms get dysregulated during normal aging and disease will also be discussed. The meeting will also cover new frontiers, including the exciting emerging field of three-dimensional chromatin structure and RNA epigenomics. The meeting will particularly focus on transformative epigenomic technologies at the single cell and single molecule levels and how they can be used to build and use ‘epigenetic clocks’ in cells from individuals at different ages and to identify novel ‘rejuvenation’ strategies for different age-related diseases. This meeting should foster exciting fundamental knowledge and information, new methodology and technical capabilities, and interdisciplinary collaborations. The meeting will also provide a uniquely interactive, diverse, and inclusive forum for trainees and new investigators in very different areas, highlighting their research through short talks, poster teasers and sessions and promoting several networking and meet-the-expert events.