FASEB's Transcription, Chromatin and Epigenetics in Aging Conference

总结 这个FASEB会议的目标“转录，染色质和衰老的表观遗传学”是涵盖 新的表观遗传机制在调节衰老和“复兴”策略中的作用， 与年龄有关的疾病。表观遗传机制包括转录后修饰， 染色质和RNA以及转录调控。这次FASEB会议将是独一无二的， 整合表观遗传学的最新发现及其在衰老和“复兴”中的重要性 与年龄有关的疾病的战略。召开这样一次会议是非常必要的。令人兴奋的最近 研究揭示了生物体和细胞的衰老是如何通过表观遗传学来调节的。 机制等表观遗传领域快速扩张，老龄化领域亟待受益 这一领域最新最伟大的发现相反，关于以下方面的挑战和问题 表观遗传学在衰老和与年龄相关的疾病中的作用比比皆是， 在染色质和转录领域，以更好地掌握他们的工作对健康的影响， 和疾病 本次FASEB会议将讨论染色质领域最前沿的问题， 转录和表观遗传学。一个关键的主题将是表观遗传的潜在分子基础 机制等这些机制在正常衰老过程中是如何失调的， 疾病也将被讨论。会议还将涉及新的领域，包括令人兴奋的 三维染色质结构和RNA表观基因组学的新兴领域。会议将 特别关注单细胞和单分子的变革性表观基因组技术 水平，以及它们如何被用来建立和使用“表观遗传时钟”的细胞从个人在 不同的年龄，并确定新的'振兴'战略，为不同的年龄相关的疾病。 这次会议应该促进令人兴奋的基本知识和信息，新的方法， 和技术能力，以及跨学科的合作。会议还将提供一个 独特的互动，多样化和包容性的论坛，为学员和新的调查人员在非常 不同的领域，通过简短的演讲，海报预告和会议突出他们的研究， 促进若干联网和会见专家活动。

SUMMARY The goal of this FASEB meeting “Transcription, Chromatin and Epigenetics in Aging” is to cover the role new epigenetic mechanisms in the regulation of aging and in ‘rejuvenation’ strategies for age-related diseases. Epigenetic mechanisms encompass post-translational modifications of chromatin and RNA as well as transcriptional regulation. This FASEB meeting will be unique in integrating the latest discoveries in epigenetics and their importance in aging and ‘rejuvenation’ strategies for age-related diseases. There is a vital need for such a meeting. Exciting recent studies have revealed how organismal and cellular aging can be regulated by epigenetic mechanisms. The field of epigenetic is rapidly expanding, and the aging field needs to benefit from the latest and greatest discoveries in this area. Conversely, challenges and questions about the role of epigenetics in aging and age-related diseases abound, and it is critical for researchers in the chromatin and transcription fields to better grasp the implications of their work for health and disease. This FASEB meeting will discuss the most cutting-edge questions in field of chromatin, transcription, and epigenetics. A key topic will be the underlying molecular basis of epigenetic mechanisms. The question of how these mechanisms get dysregulated during normal aging and disease will also be discussed. The meeting will also cover new frontiers, including the exciting emerging field of three-dimensional chromatin structure and RNA epigenomics. The meeting will particularly focus on transformative epigenomic technologies at the single cell and single molecule levels and how they can be used to build and use ‘epigenetic clocks’ in cells from individuals at different ages and to identify novel ‘rejuvenation’ strategies for different age-related diseases. This meeting should foster exciting fundamental knowledge and information, new methodology and technical capabilities, and interdisciplinary collaborations. The meeting will also provide a uniquely interactive, diverse, and inclusive forum for trainees and new investigators in very different areas, highlighting their research through short talks, poster teasers and sessions and promoting several networking and meet-the-expert events.