Ultrafast and Precise External Beam Monitor for FLASH and Other Advanced Radiation Therapy Modalities

用于 FLASH 和其他先进放射治疗方式的超快且精确的外部光束监视器

基本信息

批准号：
10324507
负责人：
Peter S Friedman
金额：
$ 56.16万
依托单位：
INTEGRATED SENSORS, LLC
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-16 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10324507
关键词：
Area Arrhythmia Atrial Fibrillation Businesses Calibration Cancer Patient Carbon ion Cardiac Clinical Clinical Trials Collaborations Community Clinical Oncology Program Cyclotrons Development Dose Dose-Rate Electron Beam Electrons Ensure Europe Feedback Funding Human Imaging technology International Ionizing radiation Ions Laboratories Legal patent Letters Licensing Methods Michigan Modality Monitor Motion Normal tissue morphology Nuclear Physics Particle Accelerators Patients Performance Phase Photons Physics Positioning Attribute Problem Solving Protons Radiation Radiation Dose Unit Radiation Oncology Radiation therapy Resolution Roentgen Rays Safety Scanning Societies Speed Synchrotrons System Techniques Technology Testing Thinness Time Tissues Toxic effect Translations Tumor Tissue Universities Update base cancer therapy carbon ion therapy clinical implementation clinical translation cost design detector dosimetry fractionated radiation improved interest ionization medical schools meetings millisecond novel particle beam patient safety prevent programs proton beam proton therapy prototype response side effect signal processing treatment duration tumor

项目摘要

Summary/Abstract FLASH radiotherapy (FLASH-RT) is a novel form of radiation therapy that promises large sparing of normal- tissues in cancer treatment while showing no tumor sparing. In FLASH-RT, the radiation dose is delivered to the tumor and normal tissues in milliseconds rather than minutes. FLASH-RT is only effective when given with large doses per fraction delivered in 1-3 treatment sessions. It would shorten a standard 30-day treatment to 1- 3 days, thus greatly reducing side-effects and radiation therapy costs to both the patient and society. The first human patient was successfully treated in 2018. The first clinical trial with ten (10) patients started in the U.S. in November 2020. Additional clinical trials are planned for 2021 in the U.S. and in Europe with at least 100 patients. A major limitation of FLASH-RT, preventing a fast translation to clinical use, is the lack of detectors capable of meeting the requirements needed to monitor and terminate the FLASH-RT treatment in real time. We propose to develop and demonstrate a large area, ultrafast and precise external beam monitor for FLASH-RT, universally suitable for electrons, protons, photons, and ions, that can terminate the beam in ≤1 ms while the patient is being treated. For this proposal, we will primarily focus on developing and demonstrating the system for electron FLASH-RT with linacs and proton FLASH-RT with existing cyclotrons, but will also demonstrate performance using X-rays. Unlike strip or wire ionization chambers, the proposed system is based on our patented (Jan 2020 and Nov 2020) ionizing-radiation beam monitoring system technology, which can provide ultrafast readout with concurrent analysis of the radiation beam position, profile, and fluence/dosimetry in real time at a rate of ≥10 kHz (i.e., beam analysis ≤100 µs). The proposed system provides real-time dosimetry, beam control, and verification for FLASH-RT. It provides an accurate 2D position and beam profile of rapidly scanned beams with a spatial resolution of a few microns over an active beam monitoring area of 26 cm x 30 cm. The beam monitor response is linear, without saturation, for all FLASH-RT beam luminosities. Proton beam testing will be primarily at the University of Michigan Ion Beam Laboratory, and electron beam testing at the Notre Dame Radiation Laboratory. The proposed program is for 3-years and will evolve from fabrication and testing of a quarter-scale beam monitor in Year 1 to a full-size system with self-calibration capability in Year 3. Our principal collaborators on this program include the University of Michigan, Physics Department, and Loma Linda University, School of Medicine. The proposed beam monitor constitutes a critical enabling technology for all types of FLASH-RT. It will ensure the safety, quality, and efficiency of FLASH radiation therapy, allowing cancer patients to be successfully treated with much higher doses, fewer side-effects, and excellent tumor control. It is also suitable for spatially fractionated radiation therapy techniques such as GRID, LATTICE, microbeam RT (MRT), and proton-minibeam RT (pMBRT). The proposed beam monitor is also being designed into a novel (patent pending) ultrafast radioablation system that eliminates the motion problem for treating cardiac arrhythmia (AFib). OMB No. 0925-0001/0002 (Rev. 01/18 Approved Through 03/31/2020) Page Continuation Format Page

摘要/摘要 Flash放射疗法（Flash-RT）是一种新型的放射治疗形式，有望大大保留正常癌症治疗中的组织没有肿瘤保留。在Flash-RT中，辐射剂量被输送到肿瘤和正常组织以毫秒而不是分钟。只有在大较大时才有效在1-3次治疗课程中提供的每分部剂量剂量。它将缩短标准的30天治疗时间到1-3天，这是如此大大降低副作用和放射治疗的成本。第一个人患者于2018年成功接受治疗。十（10）名患者在美国开始的第一次临床试验 2020年11月。计划在2021年和欧洲进行额外的临床试验，至少有100名患者。 Flash-RT的主要局限性，防止快速转化为临床使用，是缺乏能够的探测器满足实时监视和终止闪存治疗所需的要求。我们建议为了开发和演示大面积，超快和精确的外部梁监视器，用于闪存，普遍适合电子，质子，照片和离子，可以在患者处于≤1ms中终止光束治疗。对于此建议，我们将主要专注于开发和演示电子系统的系统 flash-rt与Linacs和Proton Flash-RT具有现有环状体，但也将证明性能使用X射线。与条带或电线电离室不同，拟议的系统是基于我们的专利（2020年1月和2020年11月）电离放射光束监控系统技术，可以为超快读数提供同时分析辐射束位置，轮廓和通量/剂量测定，以≥10的速度实时分析 KHz（即梁分析≤100µs）。拟议的系统提供实时剂量测定，光束控制和验证Flash-RT。它提供了准确的2D位置和快速扫描的光束的光束轮廓在26 cm x 30 cm的活动光束监测区域上的几微米的空间分辨率。梁监视器对于所有闪存束光亮度，响应是线性的，没有饱和。质子束测试将是主要的在密歇根大学离子梁实验室和巴黎圣母院辐射的电子束测试实验室。拟议的计划持续了3年，将从四分之一尺度的制造和测试中演变第1年的光束监视器到具有自校准能力的全尺寸系统。我们的主要合作者该计划包括密歇根大学，物理系和洛马·琳达大学，学校药品。提出的梁监视器构成了所有类型的闪存-RT的关键启用技术。它将确保闪光辐射疗法的安全性，质量和效率，使癌症患者成为成功治疗了更高剂量，较少的副作用和出色的肿瘤控制。这也是合适的用于空间分级的放射疗法技术，例如网格，晶格，微动RT（MRT）和 Proton-Minibeam RT（PMBRT）。提出的梁显示器也被设计成小说（申请专利）超快放射系统消除了治疗心律不齐（AFIB）的运动问题。 OMB No. 0925-0001/0002（修订版01/18通过03/31/2020批准）页面延续格式页面