Neural oscillations underlying speech perception and production in childhood stuttering

项目摘要/摘要 我们对听觉运动背后的时间动力学的理解存在一个根本的鸿沟 在口吃的儿童和成年人身上一直观察到整合缺陷。流利的演讲需要协调一致 神经活动是通过跨大脑结构的神经振荡同步实现的。这项提议将 关注促进语音网络内神经交流的振荡同步。我们的长期合作 目标是确定持续性口吃的基于经验的神经标记物，这一发现可能最终 告知儿童口吃的临床诊断和治疗。当前的总目标 应用是确定口吃儿童(CWS)在神经振荡同步方面与流利的同龄人有何不同 在语音感知和规划过程中跨越听觉-运动结构。以收集的脑电和核磁共振数据为指导 从有口吃和不口吃的儿童中，我们的中心假设是控制预测性的β振荡 通过协调运动到听觉系统的运动计时，将显示异常功率，减少间隔期 试验相聚，降低了CWS的区域间振荡位相同步。更好地理解 这一领域具有令人兴奋的治疗意义，因为在振荡模式中操纵同步性 听觉-运动系统可能通过与外部感官刺激的夹带和非侵入性的 大脑刺激。因此，这个项目将使我们能够为系统的、以神经生物学为基础的 针对CWS的干预发展。在强劲的初步数据的指导下，中心假设将得到以下检验 追求三个具体目标：1.识别和表征听觉中的β功率和振荡同步性 CWS患者在言语感知和计划过程中的运动皮质区域。2.比较Beta幂和振荡 CWS中自然语言计划和有节奏语言计划中听觉-运动皮质区域的同步性。3. 确定听觉运动区的β振荡特征与结构和功能的关系 CWS患者听觉、运动和纹状体区域之间的连通性。拟议的工作是创新的，将来也是如此。 第一系列研究旨在表征特定于语音处理的神经振荡同步性 CWS可作为儿童早期持续性口吃的高度预测性神经标志物。 研究结果将具有重大意义，因为预期结果将首次阐明因果机制 持续性口吃的听觉-运动整合缺陷的背后。这样的结果将产生重要的积极影响 影响，因为确定的流利演讲背后的神经机制将为早期有效奠定基础 对口吃的干预。

Project Summary/Abstract There is a fundamental gap in our understanding of the temporal dynamics underlying the auditory-motor integration deficits consistently observed in children and adults who stutter. Fluent speech requires coordinated neuronal activity that is achieved through neural oscillatory synchrony across brain structures. This proposal will focus on the oscillatory synchrony facilitating neural communication within the speech network. Our long-term goal is to determine empirically-based neural markers for persistent stuttering, findings that may eventually inform the clinical diagnosis and treatment of childhood stuttering. The overall objective of the present application is to determine how children who stutter (CWS) differ from fluent peers in neural oscillatory synchrony across auditory-motor structures during speech perception and planning. Guided by EEG and MRI data collected from children who do and do not stutter, our central hypothesis is that beta oscillations, which control predictive timing of movements through coordination of motor to auditory systems, will show aberrant power, reduced inter- trial phase clustering, and reduced interregional oscillatory phase synchrony in CWS. A better understanding in this area has exciting treatment implications, since manipulation of synchrony within oscillatory patterns in auditory-motor systems may be possible through entrainment with external sensory stimuli and non-invasive brain stimulation. This project will thus allow us to lay the groundwork towards systematic, neurobiology-based intervention development for CWS. Guided by strong preliminary data, the central hypotheses will be tested by pursuing three specific aims: 1. Identify and characterize beta power and oscillatory synchrony in auditory- motor cortical areas during speech perception and planning in CWS. 2. Compare beta power and oscillatory synchrony in auditory-motor cortical areas during natural and entrained (paced) speech planning in CWS. 3. Determine how beta oscillation characteristics in auditory-motor areas relate to structural and functional connectivity among auditory, motor and striatal regions in CWS. The proposed work is innovative, as it will be the first series of studies designed to characterize neural oscillatory synchrony specific to speech processing in CWS, which may serve as a highly predictive neural marker for persistent stuttering during early childhood. Findings will be significant, because the expected results will elucidate, for the first time, causal mechanisms behind auditory-motor integration deficits in persistent stuttering. Such results will have an important positive impact, as the identified neural mechanisms underlying fluent speech will lay the foundation for effective early intervention for stuttering.