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Neural oscillations underlying speech perception and production in childhood stuttering

儿童口吃中言语感知和产生的神经振荡

基本信息

批准号：
10322139
负责人：
Soo-Eun Chang
金额：
$ 51.15万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-01-01 至 2024-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10322139
关键词：
Address Adult Affect Area Auditory Auditory Perception Auditory system Bilateral Brain Brain region Characteristics Child Child Development Childhood Childhood Stuttering Clinical Treatment Communication Complex Corpus striatum structure Data Data Collection Development Developmental Stuttering Disease Early Intervention Electroencephalography Exhibits Foundations Frequencies Functional Magnetic Resonance Imaging Future Goals Intervention Lead Magnetic Resonance Imaging Mental Health Motor Motor Activity Movement Multimodal Imaging Neurobiology Neurons Neurosciences Occupational Health Outcome Participant Pattern Periodicity Persons Phase Physiological Plant Roots Production Research Design Role Sensory Series Speech Speech Perception Structure Stuttering System Techniques Testing Time Work base clinical diagnosis early childhood imaging approach innovation magnetic resonance imaging/electroencephalography neuromechanism noninvasive brain stimulation novel peer relating to nervous system response sensory stimulus speech processing therapy development therapy outcome

项目摘要

Project Summary/Abstract There is a fundamental gap in our understanding of the temporal dynamics underlying the auditory-motor integration deficits consistently observed in children and adults who stutter. Fluent speech requires coordinated neuronal activity that is achieved through neural oscillatory synchrony across brain structures. This proposal will focus on the oscillatory synchrony facilitating neural communication within the speech network. Our long-term goal is to determine empirically-based neural markers for persistent stuttering, findings that may eventually inform the clinical diagnosis and treatment of childhood stuttering. The overall objective of the present application is to determine how children who stutter (CWS) differ from fluent peers in neural oscillatory synchrony across auditory-motor structures during speech perception and planning. Guided by EEG and MRI data collected from children who do and do not stutter, our central hypothesis is that beta oscillations, which control predictive timing of movements through coordination of motor to auditory systems, will show aberrant power, reduced inter- trial phase clustering, and reduced interregional oscillatory phase synchrony in CWS. A better understanding in this area has exciting treatment implications, since manipulation of synchrony within oscillatory patterns in auditory-motor systems may be possible through entrainment with external sensory stimuli and non-invasive brain stimulation. This project will thus allow us to lay the groundwork towards systematic, neurobiology-based intervention development for CWS. Guided by strong preliminary data, the central hypotheses will be tested by pursuing three specific aims: 1. Identify and characterize beta power and oscillatory synchrony in auditory- motor cortical areas during speech perception and planning in CWS. 2. Compare beta power and oscillatory synchrony in auditory-motor cortical areas during natural and entrained (paced) speech planning in CWS. 3. Determine how beta oscillation characteristics in auditory-motor areas relate to structural and functional connectivity among auditory, motor and striatal regions in CWS. The proposed work is innovative, as it will be the first series of studies designed to characterize neural oscillatory synchrony specific to speech processing in CWS, which may serve as a highly predictive neural marker for persistent stuttering during early childhood. Findings will be significant, because the expected results will elucidate, for the first time, causal mechanisms behind auditory-motor integration deficits in persistent stuttering. Such results will have an important positive impact, as the identified neural mechanisms underlying fluent speech will lay the foundation for effective early intervention for stuttering.

项目总结/文摘