Neural oscillations underlying speech perception and production in childhood stuttering

项目概要/摘要 在我们对时间动力学的理解中，存在着一个根本性的空白， 在口吃的儿童和成人中始终观察到整合缺陷。流利的演讲需要协调 通过跨大脑结构的神经振荡同步实现的神经元活动。这项建议会 着重于促进语音网络内神经通信的振荡同步性。我们的长期 目标是确定持续性口吃的神经标记物，这些发现最终可能 告知儿童口吃的临床诊断和治疗。目前的总体目标 应用是确定如何儿童口吃（CWS）不同流利的同龄人在神经振荡同步 在言语感知和规划期间跨越听觉运动结构。由收集的EEG和MRI数据指导 从口吃和不口吃的儿童中，我们的中心假设是，控制预测性口吃的β振荡， 通过协调运动到听觉系统的运动时间，将显示出异常的功率，减少的内部， 试验阶段聚类，并减少CWS的区域间振荡相位同步。更好地理解 这一领域具有令人兴奋的治疗意义，因为在振荡模式中操纵同步性， 自主运动系统可能通过与外部感觉刺激的夹带和非侵入性 脑刺激因此，该项目将使我们能够为系统的，基于神经生物学的 发展化学武器系统的干预措施。在强有力的初步数据的指导下，中心假设将通过以下方式进行检验： 追求三个具体目标：1.识别和表征听觉中的β功率和振荡同步性- CWS中言语感知和计划的运动皮层区域。2.比较β功率和振荡功率 CWS患者在自然和诱导（起搏）语音规划过程中的运动皮层-运动皮层区域的同步性。3. 确定大脑-运动区的β振荡特征与结构和功能的关系 CWS中听觉、运动和纹状体区域之间的连接。拟议的工作是创新的，因为它将是 第一系列研究旨在表征语音处理特定的神经振荡同步性， CWS可能是儿童早期持续性口吃的高度预测性神经标志物。 研究结果将是重要的，因为预期的结果将首次阐明因果机制 在持续性口吃中的神经-运动整合缺陷背后。这样的结果将具有重要的积极意义 影响，因为确定流利语音背后的神经机制将为有效的早期治疗奠定基础。 干预口吃。

Project Summary/Abstract There is a fundamental gap in our understanding of the temporal dynamics underlying the auditory-motor integration deficits consistently observed in children and adults who stutter. Fluent speech requires coordinated neuronal activity that is achieved through neural oscillatory synchrony across brain structures. This proposal will focus on the oscillatory synchrony facilitating neural communication within the speech network. Our long-term goal is to determine empirically-based neural markers for persistent stuttering, findings that may eventually inform the clinical diagnosis and treatment of childhood stuttering. The overall objective of the present application is to determine how children who stutter (CWS) differ from fluent peers in neural oscillatory synchrony across auditory-motor structures during speech perception and planning. Guided by EEG and MRI data collected from children who do and do not stutter, our central hypothesis is that beta oscillations, which control predictive timing of movements through coordination of motor to auditory systems, will show aberrant power, reduced inter- trial phase clustering, and reduced interregional oscillatory phase synchrony in CWS. A better understanding in this area has exciting treatment implications, since manipulation of synchrony within oscillatory patterns in auditory-motor systems may be possible through entrainment with external sensory stimuli and non-invasive brain stimulation. This project will thus allow us to lay the groundwork towards systematic, neurobiology-based intervention development for CWS. Guided by strong preliminary data, the central hypotheses will be tested by pursuing three specific aims: 1. Identify and characterize beta power and oscillatory synchrony in auditory- motor cortical areas during speech perception and planning in CWS. 2. Compare beta power and oscillatory synchrony in auditory-motor cortical areas during natural and entrained (paced) speech planning in CWS. 3. Determine how beta oscillation characteristics in auditory-motor areas relate to structural and functional connectivity among auditory, motor and striatal regions in CWS. The proposed work is innovative, as it will be the first series of studies designed to characterize neural oscillatory synchrony specific to speech processing in CWS, which may serve as a highly predictive neural marker for persistent stuttering during early childhood. Findings will be significant, because the expected results will elucidate, for the first time, causal mechanisms behind auditory-motor integration deficits in persistent stuttering. Such results will have an important positive impact, as the identified neural mechanisms underlying fluent speech will lay the foundation for effective early intervention for stuttering.