Neural oscillations underlying speech perception and production in childhood stuttering

儿童口吃中言语感知和产生的神经振荡

• 批准号: 10544350
• 负责人: Soo-Eun Chang
• 金额: $ 49.64万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-01-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10544350
• 关键词: Address; Adult; Affect; Area; Auditory; Auditory Perception; Auditory system; Bilateral; Brain; Brain region; Cephalic; Characteristics; Child; Child Development; Childhood; Childhood Stuttering; Clinical Treatment; Communication; Complex; Corpus striatum structure; Data; Data Collection; Development; Developmental Stuttering; Disease; Early Intervention; Exhibits; Foundations; Frequencies; Functional Magnetic Resonance Imaging; Future; Goals; Intervention; Mental Health; Motor; Motor Activity; Motor Cortex; Movement; Multimodal Imaging; Neurobiology; Neurons; Neurosciences; Occupational Health; Outcome; Participant; Pattern; Periodicity; Persons; Phase; Physiological; Production; Research Design; Role; Sensory; Series; Speech; Speech Perception; Structure; Stuttering; System; Techniques; Testing; Time; Work; clinical diagnosis; early childhood; imaging approach; innovation; magnetic resonance imaging/electroencephalography; neural; neuromechanism; noninvasive brain stimulation; novel; peer; response; sensory stimulus; speech processing; therapy development; therapy outcome; verbal

Project Summary/Abstract There is a fundamental gap in our understanding of the temporal dynamics underlying the auditory-motor integration deficits consistently observed in children and adults who stutter. Fluent speech requires coordinated neuronal activity that is achieved through neural oscillatory synchrony across brain structures. This proposal will focus on the oscillatory synchrony facilitating neural communication within the speech network. Our long-term goal is to determine empirically-based neural markers for persistent stuttering, findings that may eventually inform the clinical diagnosis and treatment of childhood stuttering. The overall objective of the present application is to determine how children who stutter (CWS) differ from fluent peers in neural oscillatory synchrony across auditory-motor structures during speech perception and planning. Guided by EEG and MRI data collected from children who do and do not stutter, our central hypothesis is that beta oscillations, which control predictive timing of movements through coordination of motor to auditory systems, will show aberrant power, reduced inter- trial phase clustering, and reduced interregional oscillatory phase synchrony in CWS. A better understanding in this area has exciting treatment implications, since manipulation of synchrony within oscillatory patterns in auditory-motor systems may be possible through entrainment with external sensory stimuli and non-invasive brain stimulation. This project will thus allow us to lay the groundwork towards systematic, neurobiology-based intervention development for CWS. Guided by strong preliminary data, the central hypotheses will be tested by pursuing three specific aims: 1. Identify and characterize beta power and oscillatory synchrony in auditory- motor cortical areas during speech perception and planning in CWS. 2. Compare beta power and oscillatory synchrony in auditory-motor cortical areas during natural and entrained (paced) speech planning in CWS. 3. Determine how beta oscillation characteristics in auditory-motor areas relate to structural and functional connectivity among auditory, motor and striatal regions in CWS. The proposed work is innovative, as it will be the first series of studies designed to characterize neural oscillatory synchrony specific to speech processing in CWS, which may serve as a highly predictive neural marker for persistent stuttering during early childhood. Findings will be significant, because the expected results will elucidate, for the first time, causal mechanisms behind auditory-motor integration deficits in persistent stuttering. Such results will have an important positive impact, as the identified neural mechanisms underlying fluent speech will lay the foundation for effective early intervention for stuttering.

项目概要/摘要 我们对听觉运动背后的时间动态的理解存在根本差距 在口吃的儿童和成人中始终观察到整合缺陷。流畅的言语需要协调 通过跨大脑结构的神经振荡同步实现的神经元活动。该提案将 专注于促进语音网络内神经交流的振荡同步。我们的长期 目标是确定基于经验的持续性口吃的神经标记，这些发现最终可能 为儿童口吃的临床诊断和治疗提供参考。当前的总体目标 应用程序旨在确定口吃儿童 (CWS) 与流利同龄人在神经振荡同步方面有何不同 在言语感知和规划过程中跨越听觉运动结构。以收集的脑电图和核磁共振数据为指导 根据口吃和不口吃的儿童，我们的中心假设是β振荡，它控制着预测 通过运动与听觉系统的协调进行运动计时，将表现出异常的力量，减少的交互作用 试验阶段聚类，并减少 CWS 中的区域间振荡相位同步。更好地理解 这个领域具有令人兴奋的治疗意义，因为在振荡模式中操纵同步 听觉运动系统可能通过外部感觉刺激和非侵入性的夹带而成为可能 大脑刺激。因此，这个项目将使我们能够为基于神经生物学的系统化奠定基础 CWS 干预措施的开发。在强有力的初步数据的指导下，中心假设将由 追求三个具体目标： 1. 识别和表征听觉中的贝塔功率和振荡同步 CWS 中言语感知和规划期间的运动皮层区域。 2. 比较 beta 功率和振荡 CWS 中自然和夹带（节奏）言语规划期间听觉运动皮层区域的同步。 3. 确定听觉运动区域的 β 振荡特征与结构和功能的关系 CWS 听觉区、运动区和纹状体区之间的连接。拟议的工作具有创新性，因为它将 第一系列研究旨在表征特定于语音处理的神经振荡同步 CWS，它可以作为儿童早期持续性口吃的高度预测性神经标志物。 研究结果将具有重大意义，因为预期结果将首次阐明因果机制 持续性口吃的听觉运动整合缺陷背后。这样的结果将产生重要的积极作用 影响，因为已确定的流利言语背后的神经机制将为有效的早期语言奠定基础 对口吃的干预。