ELSA-HCAP 2: Second Administration of the Harmonised Cognitive Assessment Protocol (HCAP) in the English Longitudinal Study of Ageing

ELSA-HCAP 2：英国老龄化纵向研究中第二次实施统一认知评估协议 (HCAP)

• 批准号: 10445098
• 负责人: Andrew Steptoe
• 金额: $ 114.08万
• 依托单位: UNIVERSITY COLLEGE LONDON
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-30 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10445098
• 关键词: African ancestry; Age; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Asian ancestry; Behavioral; Biological; COVID-19 impact; COVID-19 risk; Caribbean region; Caring; Cessation of life; Clinical; Cognition; Cognitive; Cognitive aging; Country; Data; Data Set; Dementia; Deposition; Development; Economic Burden; Economics; Elderly; Emotional; England; Environmental Risk Factor; Epidemiology; Family; Follow-Up Studies; Funding; Future; Genetic; Grant; Great Britain; Health; Health and Retirement Study; Health system; Hospitals; Impaired cognition; Incidence; Incidence Study; Individual; Interview; Language; Link; Longitudinal Studies; Measurement; Measures; Modeling; Northern Ireland; Older Population; Outcome; Participant; Persons; Policies; Prevalence; Protocols documentation; Psychology; Publishing; Quality of life; Research Personnel; Respondent; Retirement; Risk; Risk Factors; SARS-CoV-2 infection; Sampling; Services; Social Impacts; Societies; Sociology; Taxes; Time; Universities; Variant; Walking; Woman; aged; care systems; cognitive function; cognitive performance; cognitive testing; cohort; economic impact; ethnic disparity; ethnic minority; ethnic minority population; human old age (65+); informant; insight; member; men; mild cognitive impairment; multidisciplinary; multiple chronic conditions; pandemic disease; physical conditioning; population based; prediction algorithm; racial and ethnic disparities; racial minority; response; social; social factors; socioeconomic disparity; socioeconomics; statistics; virtual; welfare

Alzheimer’s disease and Alzheimer’s disease related dementias (AD/ADRD) impose a devastating burden on society and the quality of life of sufferers and their families, and present serious challenges to health and social care. Cross-national comparisons of older populations supply valuable information about the prevalence of mild cognitive impairment and AD/ADRD in different countries, and can provide insights into the impact of different risk factors, welfare regimes, and health and social care policies. In 2018, the Harmonized Cognitive Assessment Protocol (HCAP) was completed by 1,273 participants in the English Longitudinal Study of Ageing (ELSA) aged ≥65, selected on the basis of previous cognitive performance to include individuals with low, moderate and normal cognition. Informants were also assessed. The HCAP was identical to that administered in the Health and Retirement Study (HRS) in 2016, and the common language has allowed direct comparisons between the USA and England. This proposed follow-up study will administer the HCAP in 2023 to an expanded sample that will include all surviving participants in the original study (~1,000), plus a new sample including all ethnic minority participant in ELSA aged ≥65 years and randomly selected additional cohort members to bring the achieved sample to 2,000. We expect the protocol to be very similar to that used in the original study, including face-to- face assessments with participants and interviews with informants about changes in the person’s cognitive status. The readministration of the protocol to the original sample will permit assessment of trajectories of cognitive impairment and the incidence of AD/ADRD over a 5 year period, and facilitate comparisons with the changes over time observed in the HRS. The inclusion of the ethnic minority sample will add to the limited evidence of ethnic disparities in older age cognitive function in England. Analyses will focus on socioeconomic disparities in cognitive decline, and the progression of cognitive impairment to dementia. Extrapolation to the full ELSA cohort will facilitate modeling of social and economic impacts of AD/ADRD, and will provide a basis for analyses of the multifactorial determinants of cognitive decline over the 20+ years since the study started. The study will provide detailed information on the relationship between cognition and COVID-19 risk, and on socioeconomic and ethnic disparities in the impact of the pandemic on cognition. We will prepare a well- documented anonymized dataset for deposit with the UK Data Service that will be accessible to researchers and scholars throughout the world for further analysis. This application is being submitted by Andrew Steptoe (PI) and Paola Zaninotto (Co-I) from UCL and Carol Brayne (Co-I) from the University of Cambridge, with consultants from the HRS (David Weir, Kenneth Langa), the Gateway to Global Aging (Jinkook Lee) and the Cognitive Function and Ageing Study (Fiona Matthews).

阿尔茨海默氏病和阿尔茨海默氏病相关痴呆（AD/ADRD）对阿尔茨海默氏病患者造成了毁灭性的负担。 对社会和患者及其家庭的生活质量造成严重影响，并对健康和社会构成严重挑战。 在乎对老年人群的跨国比较提供了关于轻度糖尿病患病率的有价值的信息。 认知障碍和AD/ADRD在不同的国家，并可以提供不同的影响的见解 风险因素、福利制度以及卫生和社会保健政策。2018年，统一认知评估 1，273名参加英国老龄化纵向研究（艾尔莎）的老年人完成了HCAP方案。 ≥65岁，根据既往认知表现选择，包括低、中、 正常认知。举报人也接受了评估。HCAP与健康中心管理的HCAP相同。 和退休研究（HRS）在2016年，共同语言允许直接比较 美国和英国。这项拟议的后续研究将在2023年对一个扩大的样本进行HCAP， 将包括原始研究中所有幸存的参与者（约1，000人），加上包括所有少数民族的新样本 年龄≥65岁的艾尔莎参与者和随机选择的其他队列成员， 取样到两千我们预计该方案将与原始研究中使用的方案非常相似，包括面对面- 对参与者进行面部评估，并与被调查者进行访谈，了解个人认知能力的变化 status.对原始样本重新实施方案将允许评估 认知功能障碍和AD/ADRD的发病率超过5年的时间，并促进与 在HRS中观察到的随时间的变化。纳入少数民族样本将增加有限的 英格兰老年认知功能的种族差异的证据。分析将侧重于社会经济 认知能力下降的差异，以及认知障碍向痴呆的进展。完全外推 艾尔莎队列将有助于AD/ADRD的社会和经济影响的建模，并将为 分析自研究开始以来20多年来认知能力下降的多因素决定因素。的 这项研究将提供有关认知与COVID-19风险之间关系的详细信息， 社会经济和种族差异对这一流行病认知的影响。我们会准备好- 记录的匿名数据集，用于向英国数据服务存款，研究人员可以访问， 世界各地的学者进行了进一步的分析。本申请由Andrew Steptoe（PI）提交 来自伦敦大学学院的保拉·扎尼诺托（Co-I）和来自剑桥大学的卡罗尔·布莱恩（Co-I），以及顾问 来自HRS（大卫威尔，肯尼斯朗加），全球老龄化之门（李镇国）和认知 功能和老化研究（Fiona马修斯）。