Development of a Smart PFAS-Collector for High-Throughput PFAS Detection

开发用于高通量 PFAS 检测的智能 PFAS 收集器

• 批准号: 10327033
• 负责人: Alexis Wells Carpenter
• 金额: $ 16.81万
• 依托单位: AXNANO, LLC
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10327033
• 关键词: Acids; Address; Anions; Assessment tool; Awareness; Binding; Budgets; Charge; Chemical Structure; Chemicals; Communities; Contracts; Coupled; Data; Data Analytics; Detection; Development; Devices; Electron Microscopy; Environment; Environmental Engineering technology; Equipment; Exercise; Exhibits; Exposure to; Fingerprint; Fire - disasters; Fluorescence; Formulation; Goals; Hazardous Substances; Health; Health Hazards; Human; Human Resources; Image; Imaging Device; Industry; Laboratories; Maps; Mass Spectrum Analysis; Measurable; Measures; Methods; Monitor; Municipalities; Nanotechnology; Optical Methods; Optics; Outcome; Phase; Plant Resins; Preparation; Privatization; Program Development; Property; Research; Resolution; Risk; Sampling; Screening procedure; Ships; Signal Transduction; Site; Small Business Innovation Research Grant; Societies; Solid; Solvents; Source; Specificity; Spectrum Analysis; Structure-Activity Relationship; Superfund; Surface; Technology; Testing; Time; Training; Uncertainty; Waste Products; Water; Water Supply; Work; aqueous; base; consumer product; contaminated drinking water; cost; design; detection limit; detection method; detector; drinking water; exposed human population; exposure route; feasibility testing; fighting; fluorescence imaging; functional group; ground water; improved; innovation; instrumentation; landfill; light scattering; manufacturability; materials science; multidisciplinary; nanoparticle; novel; perfluorooctanoic acid; physical property; portability; programs; prototype; screening; sensor; tool; water testing

Project Summary/Abstract 1 Rising awareness of the ubiquity of per- and polyfluoroalkyl substances (PFAS) coupled with 2 growing evidence of human health hazards has led to increased PFAS testing of water sources 3 that feed drinking-water supplies. Early estimations of the PFAS treatment market are at $3.1Bn, 4 with testing representing a key revenue driver. While highly accurate, current high resolution mass 5 spectroscopy (HRMS) PFAS detection methods have high per sample costs and long turnaround 6 times. The specialized equipment is expensive and requires skilled personnel and laborious 7 sample preparation. As a result, budget-strapped stakeholders may limit the comprehensive 8 testing needed for site assessment. Long turnaround times can mean continued community 9 exposure and uncertainty of clean-up progress. AxNano is developing a low-cost, high- 10 throughput, portable PFAS-detection method. We aim to initially develop this as a screening tool 11 for environmental engineers to provide real-time data of elevated PFAS levels to inform exposures 12 and further testing needs. Long-term goals are to achieve specificity and detection limits 13 necessary for receiving EPA approval. This technology meets the specific Superfund Research 14 Program need of “nanotechnology-based sensors” to “characterize [and] monitor hazardous 15 substances at contaminated sites”. 16 The specific objectives of this Phase I SBIR program are the development of and bench-scale 17 testing of AxNano’s PFAS-targeting “smart” collector, which is a key component of our high 18 throughput PFAS detector. The long-term objectives of this multidisciplinary technology 19 development program will integrate material science, advanced spectroscopy, and data analytics. 20 The key innovation in this work is unique PFAS-targeting nanoparticles that will produce a 21 fluorescence signal upon binding PFAS. Our initial goal is ppb level detection, and ultimately ppt 22 to meet regulatory requirements. Specific tasks of this Phase I include lab-scale manufacturing of 23 a suite of surface-modified fluorescent nanoparticles and testing for PFAS-targeting and - 24 detecting abilities. Promising candidates will be down-selected according to specific criteria and 25 integrated into a pre-prototype “smart” collector, which will then be tested at bench-scale. Phase 26 I will test proof-of-concept against standard solutions of perfluorooctanoic acid (PFOA), 27 perfluorooctanesulfonic acid (PFOS), and an Aqueous Fire Fighting Foam (AFFF) Ansulite. 28 Additional tasks involve preparing for prototyping and broader PFAS compound testing in realistic 29 environments in Phase II.

项目总结/摘要 1对全氟烷基和多氟烷基物质（PFAS）普遍存在的认识不断提高， 2越来越多的证据表明人类健康危害导致水源的PFAS测试增加 三是饮用水供应。PFAS治疗市场的早期估计为31亿美元， 4，测试代表了一个关键的收入驱动因素。虽然高度准确，目前的高分辨率质量 5光谱（HRMS）PFAS检测方法具有高的样品成本和长的周转时间 六次。专用设备是昂贵的，并且需要熟练的人员和费力的操作。 7样品制备。因此，经济拮据的利益相关者可能会限制全面的 现场评估所需的8项测试。漫长的周转时间可能意味着持续的社区 9.暴露和清理进展的不确定性。AxNano正在开发一种低成本、高... 10通量，便携式PFAS检测方法。我们的目标是首先将其开发为筛选工具 环境工程师提供PFAS水平升高的实时数据，以告知暴露情况 12、进一步的测试。长期目标是达到特异性和检测限 13需要获得EPA批准。这项技术符合特定的超级基金研究 14.“基于纳米技术的传感器”的方案需要，以“表征[和]监测危险 污染场地的15种物质”。 第一阶段SBIR计划的具体目标是开发和实验室规模的 17测试AxNano的PFAS目标“智能”收集器，这是我们的高性能的关键组成部分， 18通量PFAS检测器。这项多学科技术的长期目标是 19开发计划将整合材料科学，先进的光谱学和数据分析。 这项工作的关键创新是独特的PFAS靶向纳米颗粒，它将产生一种 图21结合PFAS后的荧光信号。我们最初的目标是ppb级检测，最终是ppt 22、符合法规要求。第一阶段的具体任务包括实验室规模生产 23一套表面改性的荧光纳米颗粒和PFAS靶向测试， 24种检测能力有前途的候选人将根据具体标准进行筛选， 25集成到一个预原型“智能”收集器，然后将在实验室规模进行测试。相 26我将对照全氟辛酸（PFOA）的标准溶液进行概念验证测试， 27全氟辛烷磺酸（PFOS）和水性灭火泡沫（AFFF）Ansulite。 28其他任务包括准备原型和更广泛的PFAS化合物测试， 第二阶段的29个环境。