Development of a Smart PFAS-Collector for High-Throughput PFAS Detection

开发用于高通量 PFAS 检测的智能 PFAS 收集器

• 批准号: 10327033
• 负责人: Alexis Wells Carpenter
• 金额: $ 16.81万
• 依托单位: AXNANO, LLC
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10327033
• 关键词: Acids; Address; Anions; Assessment tool; Awareness; Binding; Budgets; Charge; Chemical Structure; Chemicals; Communities; Contracts; Coupled; Data; Data Analytics; Detection; Development; Devices; Electron Microscopy; Environment; Environmental Engineering technology; Equipment; Exercise; Exhibits; Exposure to; Fingerprint; Fire - disasters; Fluorescence; Formulation; Goals; Hazardous Substances; Health; Health Hazards; Human; Human Resources; Image; Imaging Device; Industry; Laboratories; Maps; Mass Spectrum Analysis; Measurable; Measures; Methods; Monitor; Municipalities; Nanotechnology; Optical Methods; Optics; Outcome; Phase; Plant Resins; Preparation; Privatization; Program Development; Property; Research; Resolution; Risk; Sampling; Screening procedure; Ships; Signal Transduction; Site; Small Business Innovation Research Grant; Societies; Solid; Solvents; Source; Specificity; Spectrum Analysis; Structure-Activity Relationship; Superfund; Surface; Technology; Testing; Time; Training; Uncertainty; Waste Products; Water; Water Supply; Work; aqueous; base; consumer product; contaminated drinking water; cost; design; detection limit; detection method; detector; drinking water; exposed human population; exposure route; feasibility testing; fighting; fluorescence imaging; functional group; ground water; improved; innovation; instrumentation; landfill; light scattering; manufacturability; materials science; multidisciplinary; nanoparticle; novel; perfluorooctanoic acid; physical property; portability; programs; prototype; screening; sensor; tool; water testing

Project Summary/Abstract 1 Rising awareness of the ubiquity of per- and polyfluoroalkyl substances (PFAS) coupled with 2 growing evidence of human health hazards has led to increased PFAS testing of water sources 3 that feed drinking-water supplies. Early estimations of the PFAS treatment market are at $3.1Bn, 4 with testing representing a key revenue driver. While highly accurate, current high resolution mass 5 spectroscopy (HRMS) PFAS detection methods have high per sample costs and long turnaround 6 times. The specialized equipment is expensive and requires skilled personnel and laborious 7 sample preparation. As a result, budget-strapped stakeholders may limit the comprehensive 8 testing needed for site assessment. Long turnaround times can mean continued community 9 exposure and uncertainty of clean-up progress. AxNano is developing a low-cost, high- 10 throughput, portable PFAS-detection method. We aim to initially develop this as a screening tool 11 for environmental engineers to provide real-time data of elevated PFAS levels to inform exposures 12 and further testing needs. Long-term goals are to achieve specificity and detection limits 13 necessary for receiving EPA approval. This technology meets the specific Superfund Research 14 Program need of “nanotechnology-based sensors” to “characterize [and] monitor hazardous 15 substances at contaminated sites”. 16 The specific objectives of this Phase I SBIR program are the development of and bench-scale 17 testing of AxNano’s PFAS-targeting “smart” collector, which is a key component of our high 18 throughput PFAS detector. The long-term objectives of this multidisciplinary technology 19 development program will integrate material science, advanced spectroscopy, and data analytics. 20 The key innovation in this work is unique PFAS-targeting nanoparticles that will produce a 21 fluorescence signal upon binding PFAS. Our initial goal is ppb level detection, and ultimately ppt 22 to meet regulatory requirements. Specific tasks of this Phase I include lab-scale manufacturing of 23 a suite of surface-modified fluorescent nanoparticles and testing for PFAS-targeting and - 24 detecting abilities. Promising candidates will be down-selected according to specific criteria and 25 integrated into a pre-prototype “smart” collector, which will then be tested at bench-scale. Phase 26 I will test proof-of-concept against standard solutions of perfluorooctanoic acid (PFOA), 27 perfluorooctanesulfonic acid (PFOS), and an Aqueous Fire Fighting Foam (AFFF) Ansulite. 28 Additional tasks involve preparing for prototyping and broader PFAS compound testing in realistic 29 environments in Phase II.

项目总结/文摘