Development of a Smart PFAS-Collector for High-Throughput PFAS Detection

开发用于高通量 PFAS 检测的智能 PFAS 收集器

• 批准号: 10327033
• 负责人: Alexis Wells Carpenter
• 金额: $ 16.81万
• 依托单位: AXNANO, LLC
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10327033
• 关键词: Acids; Address; Anions; Assessment tool; Awareness; Binding; Budgets; Charge; Chemical Structure; Chemicals; Communities; Contracts; Coupled; Data; Data Analytics; Detection; Development; Devices; Electron Microscopy; Environment; Environmental Engineering technology; Equipment; Exercise; Exhibits; Exposure to; Fingerprint; Fire - disasters; Fluorescence; Formulation; Goals; Hazardous Substances; Health; Health Hazards; Human; Human Resources; Image; Imaging Device; Industry; Laboratories; Maps; Mass Spectrum Analysis; Measurable; Measures; Methods; Monitor; Municipalities; Nanotechnology; Optical Methods; Optics; Outcome; Phase; Plant Resins; Preparation; Privatization; Program Development; Property; Research; Resolution; Risk; Sampling; Screening procedure; Ships; Signal Transduction; Site; Small Business Innovation Research Grant; Societies; Solid; Solvents; Source; Specificity; Spectrum Analysis; Structure-Activity Relationship; Superfund; Surface; Technology; Testing; Time; Training; Uncertainty; Waste Products; Water; Water Supply; Work; aqueous; base; consumer product; contaminated drinking water; cost; design; detection limit; detection method; detector; drinking water; exposed human population; exposure route; feasibility testing; fighting; fluorescence imaging; functional group; ground water; improved; innovation; instrumentation; landfill; light scattering; manufacturability; materials science; multidisciplinary; nanoparticle; novel; perfluorooctanoic acid; physical property; portability; programs; prototype; screening; sensor; tool; water testing

Project Summary/Abstract 1 Rising awareness of the ubiquity of per- and polyfluoroalkyl substances (PFAS) coupled with 2 growing evidence of human health hazards has led to increased PFAS testing of water sources 3 that feed drinking-water supplies. Early estimations of the PFAS treatment market are at $3.1Bn, 4 with testing representing a key revenue driver. While highly accurate, current high resolution mass 5 spectroscopy (HRMS) PFAS detection methods have high per sample costs and long turnaround 6 times. The specialized equipment is expensive and requires skilled personnel and laborious 7 sample preparation. As a result, budget-strapped stakeholders may limit the comprehensive 8 testing needed for site assessment. Long turnaround times can mean continued community 9 exposure and uncertainty of clean-up progress. AxNano is developing a low-cost, high- 10 throughput, portable PFAS-detection method. We aim to initially develop this as a screening tool 11 for environmental engineers to provide real-time data of elevated PFAS levels to inform exposures 12 and further testing needs. Long-term goals are to achieve specificity and detection limits 13 necessary for receiving EPA approval. This technology meets the specific Superfund Research 14 Program need of “nanotechnology-based sensors” to “characterize [and] monitor hazardous 15 substances at contaminated sites”. 16 The specific objectives of this Phase I SBIR program are the development of and bench-scale 17 testing of AxNano’s PFAS-targeting “smart” collector, which is a key component of our high 18 throughput PFAS detector. The long-term objectives of this multidisciplinary technology 19 development program will integrate material science, advanced spectroscopy, and data analytics. 20 The key innovation in this work is unique PFAS-targeting nanoparticles that will produce a 21 fluorescence signal upon binding PFAS. Our initial goal is ppb level detection, and ultimately ppt 22 to meet regulatory requirements. Specific tasks of this Phase I include lab-scale manufacturing of 23 a suite of surface-modified fluorescent nanoparticles and testing for PFAS-targeting and - 24 detecting abilities. Promising candidates will be down-selected according to specific criteria and 25 integrated into a pre-prototype “smart” collector, which will then be tested at bench-scale. Phase 26 I will test proof-of-concept against standard solutions of perfluorooctanoic acid (PFOA), 27 perfluorooctanesulfonic acid (PFOS), and an Aqueous Fire Fighting Foam (AFFF) Ansulite. 28 Additional tasks involve preparing for prototyping and broader PFAS compound testing in realistic 29 environments in Phase II.

项目概要/摘要 1 人们越来越认识到全氟烷基物质和多氟烷基物质 (PFAS) 的普遍存在，以及 2 越来越多的证据表明对人类健康有害，因此增加了对水源的 PFAS 检测 3 提供饮用水供应。 PFAS 治疗市场的早期估计为 31 亿美元， 4 测试是关键的收入驱动因素。虽然精度很高，但目前的高分辨率质量 5 光谱 (HRMS) PFAS 检测方法的每个样品成本较高且周转时间较长 6次。专用设备价格昂贵，需要熟练的人员和劳力 7 样品制备。因此，预算紧张的利益相关者可能会限制全面的 现场评估所需的 8 项测试。较长的周转时间可能意味着持续的社区 9 暴露和清理进度的不确定性。 AxNano 正在开发一种低成本、高 10 通量、便携式 PFAS 检测方法。我们的目标是首先将其开发为筛选工具 11 供环境工程师提供 PFAS 水平升高的实时数据，以告知暴露情况 12 以及进一步的测试需求。长期目标是实现特异性和检测限 13 获得 EPA 批准所必需的。该技术符合特定的超级基金研究 14 项目需要“基于纳米技术的传感器”来“表征[和]监测危险 污染地点的 15 种物质”。 16 第一阶段 SBIR 计划的具体目标是开发和试验规模 对 AxNano 的针对 PFAS 的“智能”收集器进行了 17 次测试，该收集器是我们高品质产品的关键组成部分 18 通量 PFAS 检测器。这项多学科技术的长期目标 19 开发计划将整合材料科学、先进光谱学和数据分析。 20 这项工作的关键创新是独特的 PFAS 靶向纳米颗粒，它将产生 21 结合 PFAS 时的荧光信号。我们最初的目标是ppb级检测，最终是ppt 22 满足监管要求。第一阶段的具体任务包括实验室规模制造 23 一套表面改性荧光纳米粒子和 PFAS 靶向测试以及 - 24种检测能力。有前途的候选人将根据具体标准进行筛选 25 集成到预原型“智能”收集器中，然后将在实验室规模上进行测试。阶段 26 我将根据全氟辛酸 (PFOA) 标准溶液测试概念验证， 27 全氟辛烷磺酸 (PFOS) 和水性消防泡沫 (AFFF) Ansulite。 28 其他任务包括准备原型设计和更广泛的 PFAS 化合物实际测试 第二阶段有 29 个环境。