BU Clinical HIV/AIDS Research Training Program (BU-CHART

项目总结/摘要 波士顿大学临床艾滋病毒/艾滋病研究培训（BU-CHART）计划培养优秀的医学博士 和博士培训学员，使其成为艾滋病毒/艾滋病研究领域的科学领导人，重点是 弱势群体和得不到充分服务的群体。BU-CHART将其培训计划的重点放在四个高度优先的艾滋病毒方面 研究领域，以解决仍然存在的重大挑战，以结束艾滋病毒流行：1）物质 使用和艾滋病毒-一种物质使用障碍和艾滋病毒感染的综合征在美国引发了艾滋病毒的爆发， 东欧和亚洲。2)结核病和HCV合并感染-合并症，包括结核病和 丙型肝炎病毒是艾滋病毒感染者死亡的主要原因; 3）艾滋病毒传播和 潜伏期的建立-艾滋病毒的发病率仍然顽固地上升， 仍然是一个令人沮丧的难题，限制了寻找艾滋病毒治愈方法的进展; 4）艾滋病毒治疗和加速 衰老过程-我们仍然寻求安全有效的干预措施，以减少不适当的免疫激活， 伴随HIV感染并导致终末器官疾病。培训设施包括最先进的 波士顿大学医学院和公共卫生学院以及波士顿医学中心的研究空间， 新英格兰最大的安全网医院BU-CHART与校园内现有的培训项目协同增效， 包括BU临床和转化科学研究所（CTSI），普罗维登斯-波士顿艾滋病中心 研究，和其他T32和R25资助的培训计划在BUMC校园。我们将杰出的 学员与BU-CHART教师导师谁是既定的调查与NIH资助的研究项目 和经验指导。我们提供了一个深思熟虑的科学推理训练计划， 实验设计、专业发展和人类研究的道德行为。其结果是一个 培训成功的记录。在过去的15年里，BU-CHART培养了26名MD和PhD博士后 研究员，其中20人（77%）留在学术职位专注于艾滋病毒研究。7名学员中， 谁完成了该计划在当前的赠款周期，6现在有学术研究职位，3有 已获得职业发展奖，2人的职业发展奖正在审查中。

PROJECT SUMMARY/ABSTRACT The Boston University Clinical HIV/AIDS Research Training (BU-CHART) program prepares outstanding M.D and Ph.D. trainees for careers as scientific leaders in HIV/AIDS research, with a focus on research in disadvantaged and underserved populations. BU-CHART focuses its training plan on four high-priority HIV research fields that address the substantial challenges that remain to ending the HIV epidemic: 1) substance use and HIV - a syndemic of substance use disorders and HIV infection fuels HIV outbreaks in the U.S., Eastern Europe, and Asia. 2) Tuberculosis and HCV co-infection - comorbidities, including Tuberculosis and Hepatitis C Virus are leading causes of death among HIV-infected people; 3) HIV transmission and establishment of latency - HIV incidence remains stubbornly elevated, and early establishment of HIV latency remains a frustrating puzzle that limits progress to finding HIV cure; 4) HIV treatment and the accelerated aging process - we still seek safe and effective interventions to reduce the inappropriate immune activation that accompanies HIV infection and leads to end-organ disease. The training facilities include state-of-the-art research space at Boston University Schools of Medicine and Public Health and Boston Medical Center, the largest Safety-net hospital in New England. BU-CHART synergizes with existing training programs on campus, including the BU Clinical and Translational Science Institute (CTSI), the Providence-Boston Center for AIDS Research, and other T32- and R25-funded training programs on the BUMC campus. We pair our outstanding trainees with BU-CHART faculty mentors who are established investigators with NIH-funded research projects and experience mentoring. We provide a thoughtfully constructed training plan in scientific reasoning and experimental design, professional development, and the ethical conduct of human research. The result is a track record of training success. In the past 15 years, BU-CHART trained 26 MD and PhD post-doctoral fellows, of whom 20 (77%) remain in in academic positions focused on HIV research. Among the 7 trainees who completed the program in the current grant cycle, 6 now have academic research positions, 3 have already obtained career development awards, and 2 have career development awards currently under review.