Core A: University of Kentucky Alzheimer's Disease Core Center

核心 A：肯塔基大学阿尔茨海默病核心中心

• 批准号: 10459466
• 负责人: LINDA J VAN ELDIK
• 金额: $ 27.88万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10459466
• 关键词: Administrator; Alzheimer' s Disease; Alzheimer' s Disease Core Center; Alzheimer' s disease related dementia; Autopsy; Biological; Brain; Brain Pathology; Capital; Caregivers; Cessation of life; Clinical; Cognitive; Cognitive aging; Collaborations; Communication; Communities; Dementia; Development; Doctor of Philosophy; Elderly; Ensure; Environment; Etiology; Fostering; Foundations; Goals; Heterogeneity; Human Resources; Human Volunteers; Impaired cognition; Individual; Infrastructure; Kentucky; Knowledge; Leadership; Modality; Monitor; Neurosciences; Occupational activity of managing finances; Pathogenicity; Pathology; Patients; Prevention; Research; Research Activity; Research Personnel; Resources; Risk; Risk Factors; Science; Strategic Planning; Structure; System; Tissues; Training and Education; Translational Research; United States; Universities; accurate diagnostics; beneficiary; cognitive development; cohort; comorbidity; diagnostic strategy; disease heterogeneity; effective therapy; innovation; meetings; multidisciplinary; novel therapeutics; pre-clinical; prevent; programs; success; training opportunity; treatment strategy; volunteer

Project Summary/Abstract: Administrative Core The ultimate goal of the UK-ADRC is to catalyze innovative and outstanding AD research while ensuring a more rapid rate of progress toward new therapies to delay or prevent AD, so that our human volunteers, patients and caregivers become the beneficiaries of our advances in knowledge. The Administrative Core provides the foundation, infrastructure, leadership, overall direction, strategic planning, and integration of all ADRC components to more rapidly achieve this goal and advance our overall theme: “Transitions from Normal to Late-Life Multi-Etiology Dementia”. This theme builds on our traditional strengths in defining mechanisms underlying the early changes that occur in individuals as they transition through the cognitive continuum, risk factors associated with these cognitive states, and how mixed pathology and co-morbidities influence risk and progression. Two historically outstanding resources of the UK-ADRC that enable research relevant to this theme are: 1) a strong autopsy program providing clinical-neuropathological correlation and very short (2-4 hrs) postmortem interval (PMI) research material, and 2) a unique, continuously replenished group of ~500 cognitively intact subjects followed longitudinally, together with another ~300 initially normal individuals who transition to pre-MCI, MCI or dementia, and all committed to brain autopsy upon death. These signature resources have contributed to our becoming one of the premier centers defining pathogenic mechanisms underlying the transitions from normal cognitive aging to the earliest stages of cognitive impairment. The UK- ADRC functions in a multidisciplinary, integrated, collaborative and supportive team science environment that catalyzes high-quality AD research within the UK community, region, nation, and beyond. We will continue to provide the infrastructure, resources and intellectual capital to enhance transdisciplinary research and scientific interactions, develop new collaborations and partnerships, contribute to national initiatives, and offer innovative education and training opportunities in the basic and clinical neurosciences. An effective Administrative Core is essential for transforming our goals into accomplishments. Therefore, the Core will continue to support the ability of our UK-ADRC to accomplish its goals, and to promote the NAPA research implementation milestones and goals, through the following specific aims. Aim 1: Provide leadership, administrative structure, coordination, and financial management to ensure optimal resource utilization to meet the overall goals of the UK-ADRC. Aim 2: Promote and catalyze clinical/translational research activities, maximize interactions with other departments and centers, and foster new avenues of innovative research. Aim 3: Solicit, review, select, and monitor the Developmental Projects. Aim 4: Contribute to and interact with other ADRCs and other national collaborative activities and increase visibility in the local and national community.

项目概要/摘要：行政核心 UK-ADRC的最终目标是促进创新和优秀的AD研究，同时确保 以更快的速度发展新的治疗方法来延缓或预防AD，这样我们的人类志愿者， 病人和护理人员成为我们知识进步的受益者。行政核心 提供基础、基础设施、领导、总体方向、战略规划和所有 ADRC组件，以更快地实现这一目标，并推进我们的整体主题：“从正常的过渡 多病因老年痴呆症”这一主题建立在我们在确定机制方面的传统优势之上 在个体经历认知连续体的过渡过程中， 与这些认知状态相关的因素，以及混合病理和共病如何影响风险和 进展英国ADRC的两个历史上杰出的资源，使相关的研究， 主题是：1）强有力的尸检程序提供临床-神经病理学相关性和非常短的时间（2-4小时） 死后间隔（PMI）研究材料，和2）一个独特的，不断补充组约500 认知完整的受试者与另外300名最初正常的个体一起纵向跟踪， 向轻度认知障碍前期、轻度认知障碍或痴呆过渡，并在死亡后进行脑尸检。这些签名 我们的资源使我们成为确定致病机制的主要中心之一 从正常认知老化到认知障碍的早期阶段的过渡。英国- ADRC在多学科，综合，协作和支持团队科学环境中发挥作用， 促进英国社区，地区，国家和其他地区的高质量AD研究。我们将继续 提供基础设施、资源和智力资本，以加强跨学科研究和科学 互动，发展新的合作和伙伴关系，促进国家倡议，并提供创新的 基础和临床神经科学的教育和培训机会。一个有效的行政核心是 这是将我们的目标转化为成就的关键。因此，核心将继续支持 我们的英国-ADRC实现其目标的能力，并促进国家适应行动方案研究实施里程碑 通过以下具体目标实现目标。 目标1：提供领导、行政结构、协调和财务管理，以确保最佳 资源利用，以满足英国ADRC的总体目标。 目标2：促进和催化临床/转化研究活动，最大限度地与其他研究人员进行互动 部门和中心，并促进创新研究的新途径。 目标3：征求、审查、选择和监督发展项目。 目标4：为其他发展成果中心和其他国家合作活动作出贡献并与其互动， 在当地和国家社区的知名度。