Portable and modular UDS Data Collection software to increase collaboration and engagement of Alzheimer’s Disease Research Center research software engineers

项目总结 这是对肯塔基大学阿尔茨海默病研究中心的行政补充申请 中心(英国-ADRC)，响应NOT-OD-22-068，支持行政补充文件提交 加强开放科学的软件工具。我们正在申请资金来支持数据管理 和统计(DMS)核心，用于与非OD-22-068相关的数据管理活动。英国-ADRC是一个 经验丰富的协作中心，其主要使命是提供环境和核心资源 这促进了创新研究、推广、教育和临床项目。我们的首要主题是 从正常到老年多病因性痴呆的转变。我们的特点很好的纵向队列 和历史上强大的神经病理学计划，专注于正常衰老、临床前疾病状态和早期 认知转变是我们成功定义早期致病机制的核心。 从正常认知老化到功能障碍的转变。此外，这些努力一直是我们 对老年痴呆的异质性和多种病理特征的认识。我们强大而强大的 有源DMS核心是ADRC核心集成的关键，也是英国ADRC成功的关键。完毕 多年来，ADRC的数据收集在范围、规模和复杂性方面都有所增长，不仅包括 UDS数据，而是大量并行的数据收集，涵盖临床、成像、生物显微镜、生物标志物和 ADRC纵向队列的生物统计数据以及其他相关研究。DMS核心 我开发了一个基于云的.NET Core MVC Web应用程序来收集UDS数据 具有各种互连的数据源和存储的现有企业生态系统。我们在这里求婚 对代码库的增强，包括重构代码库以实现互操作性，添加自动 测试可持续社区参与的工具，并实施集装箱化以促进广泛的 一系列部署环境。 该副刊的具体目的是： 目标1：通过重构当前代码库来分离数据访问层，从而提高软件互操作性 来自表示层的。 目标2：通过添加自动化测试工具来准备，促进ADRC开发人员社区参与 外部贡献的代码库。 目标3：通过集装箱化提高软件的可移植性和ADRC的采用率。 这些软件工具不仅对英国-ADRC非常有用，而且对全国ADRC社区也是如此 增强在强大的大规模研究环境中整合数据的能力。

PROJECT SUMMARY This is an administrative supplement application to the University of Kentucky Alzheimer’s Disease Research Center (UK-ADRC), submitted in response to NOT-OD-22-068, Administrative Supplements to Support Enhancement of Software Tools for Open Science. We are requesting funds to support the Data Management and Statistics (DMS) Core for data management activities relevant to NOT-OD-22-068. The UK-ADRC is an experienced and collaborative Center whose principal mission is to provide an environment and core resources that catalyze innovative research, outreach, education and clinical programs. Our overarching theme is Transitions from Normal to Late-Life Multi-Etiology Dementia. Our well-characterized, longitudinal cohort and historically strong neuropathology program focused on normal aging, preclinical disease states and early cognitive transitions have been central to our success in defining early pathogenic mechanisms underlying the transitions from normal cognitive aging to impairment. In addition, these efforts have been a driving force in our recognition of the heterogeneity and multiple pathologies that characterize late-life dementia. Our strong and active DMS Core is critical for integration of the ADRC Cores and is vital to the success of the UK-ADRC. Over the years, ADRC data collection has grown in scope, scale, and complexity to include not just collection of UDS data but a multitude of parallel data collections covering clinical, imaging, biospecimens, biomarker, and biometric data across the ADRC longitudinal cohort as well as other related research studies. The DMS Core has developed a cloud-based .NET Core MVC web application to collect UDS data in a way that works within an existing enterprise ecosystem with varied interconnected data sources and stores. We propose here enhancements to the codebase that include refactoring the codebase for interoperability, adding automated testing tools for sustainable community engagement, and implementing containerization to facilitate a wide range of deployment environments. The specific aims of the supplement are: AIM 1: Increase software interoperability by refactoring current codebase to decouple the data access layer from the presentation layer. AIM 2: Promote ADRC developer community engagement by adding automated testing tools to prepare codebase for external contributions. AIM 3: Increase portability and ADRC adoption of software through containerization. These software tools will be extremely useful not just to the UK-ADRC, but to the national ADRC community by enhancing the ability to integrate data within a robust large-scale research environment.