Portable and modular UDS Data Collection software to increase collaboration and engagement of Alzheimer’s Disease Research Center research software engineers

便携式模块化 UDS 数据收集软件，可增强阿尔茨海默病研究中心研究软件工程师的协作和参与

• 批准号: 10608722
• 负责人: LINDA J VAN ELDIK
• 金额: $ 22.93万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10608722
• 关键词: Administrative Supplement; Adoption; Alzheimer' s Disease; Alzheimer' s disease model; Biological Markers; Biometry; Clinical; Code; Cognitive; Cognitive aging; Collaborations; Collection; Communities; Community Developments; Computer software; Data; Data Collection; Data Sources; Data Store; Database Management Systems; Decision Making; Dementia; Development; Disease; Ecosystem; Education; Elderly; Environment; Etiology; Funding; Genetic; Goals; Growth; Heterogeneity; Human Resources; Hybrids; Image; Impairment; Individual; Infrastructure; Investments; Kentucky; Libraries; Longitudinal Studies; Longitudinal cohort; Maintenance; Mission; Modeling; Modernization; Pathogenicity; Pathology; Research; Resources; Secure; Software Engineering; Software Tools; Technology; Testing; Universities; Work; cloud based; community center; community engagement; data access; data management; driving force; experience; flexibility; improved; infancy; innovation; interoperability; neuroimaging; neuropathology; normal aging; open data; open source; operation; outreach; portability; pre-clinical; programs; recruit; research study; response; software development; statistics; success; tool; web app

PROJECT SUMMARY This is an administrative supplement application to the University of Kentucky Alzheimer’s Disease Research Center (UK-ADRC), submitted in response to NOT-OD-22-068, Administrative Supplements to Support Enhancement of Software Tools for Open Science. We are requesting funds to support the Data Management and Statistics (DMS) Core for data management activities relevant to NOT-OD-22-068. The UK-ADRC is an experienced and collaborative Center whose principal mission is to provide an environment and core resources that catalyze innovative research, outreach, education and clinical programs. Our overarching theme is Transitions from Normal to Late-Life Multi-Etiology Dementia. Our well-characterized, longitudinal cohort and historically strong neuropathology program focused on normal aging, preclinical disease states and early cognitive transitions have been central to our success in defining early pathogenic mechanisms underlying the transitions from normal cognitive aging to impairment. In addition, these efforts have been a driving force in our recognition of the heterogeneity and multiple pathologies that characterize late-life dementia. Our strong and active DMS Core is critical for integration of the ADRC Cores and is vital to the success of the UK-ADRC. Over the years, ADRC data collection has grown in scope, scale, and complexity to include not just collection of UDS data but a multitude of parallel data collections covering clinical, imaging, biospecimens, biomarker, and biometric data across the ADRC longitudinal cohort as well as other related research studies. The DMS Core has developed a cloud-based .NET Core MVC web application to collect UDS data in a way that works within an existing enterprise ecosystem with varied interconnected data sources and stores. We propose here enhancements to the codebase that include refactoring the codebase for interoperability, adding automated testing tools for sustainable community engagement, and implementing containerization to facilitate a wide range of deployment environments. The specific aims of the supplement are: AIM 1: Increase software interoperability by refactoring current codebase to decouple the data access layer from the presentation layer. AIM 2: Promote ADRC developer community engagement by adding automated testing tools to prepare codebase for external contributions. AIM 3: Increase portability and ADRC adoption of software through containerization. These software tools will be extremely useful not just to the UK-ADRC, but to the national ADRC community by enhancing the ability to integrate data within a robust large-scale research environment.

项目摘要 这是肯塔基州大学阿尔茨海默病研究所的行政补充申请 中心（UK-ADRC），为响应NOT-OD-22-068，支持的行政补充文件而提交 增强开放科学的软件工具。我们正在申请资金支持数据管理 与NOT-OD-22-068相关的数据管理活动的数据和统计（DMS）核心。英国ADRC是一个 一个经验丰富的协作中心，其主要使命是提供一个环境和核心资源 促进创新研究、推广、教育和临床项目。我们的首要主题是 从正常到晚年多病因痴呆症的转变。我们特征鲜明的纵向队列 和历史上强大的神经病理学计划专注于正常衰老，临床前疾病状态和早期 认知转变是我们成功定义早期致病机制的核心， 从正常认知老化到认知障碍的转变。此外，这些努力也是我们 认识到老年痴呆症的异质性和多种病理特征。我们强大而 有源DMS核心对于ADRC核心的集成至关重要，对于UK-ADRC的成功至关重要。超过 这些年来，ADRC数据收集的范围、规模和复杂性都在增长，不仅包括收集 UDS数据，但涵盖临床、成像、生物标本、生物标志物和 ADRC纵向队列以及其他相关研究的生物特征数据。DMS核心 开发了一个基于云的.NET Core MVC Web应用程序，以一种在 一个现有的企业生态系统，具有各种互连的数据源和存储。我们在此提议 对代码库的增强，包括重构代码库以实现互操作性， 测试可持续社区参与的工具，并实施容器化，以促进广泛的 一系列部署环境。 该补编的具体目标是： 目标1：通过重构当前代码库以解耦数据访问层来提高软件互操作性 从表示层。 目标2：通过添加自动化测试工具来促进ADRC开发人员社区的参与， 外部贡献的代码库。 目标3：通过容器化提高软件的可移植性和ADRC采用率。 这些软件工具不仅对英国ADRC非常有用，而且对国家ADRC社区也非常有用， 增强在强大的大规模研究环境中整合数据的能力。