University of Kentucky Alzheimer's Disease Research Center

项目摘要/摘要：总体 肯塔基大学阿尔茨海默病研究中心(UK-ADRC)是一家经验丰富的 协作中心，促进了AD和相关痴呆(ADRD)的开创性研究 成立于1985年。我们的主要使命是作为英国所有与AD相关的活动的协调中心 通过提供促进创新研究的环境和核心资源， 外展、教育和临床计划。我们的签名资源包括：1)一个认知正常的群 约500名受试者进行了纵向跟踪，另有约300名受试者过渡到MCI或 痴呆症，所有人死后都要进行脑部尸检；2)强大的尸检计划，具有临床- 神经病理相关性和短死后间隔研究材料；3)一个成熟的计划 研究混合病理的早期临床前生物学现象及其对晚年生活的影响 痴呆症状态，越来越重视生前生物标记物的收集；4)综合集中 数据库和创新的生物统计学专门知识，以确定临床和生物转变的特征；5)a 与非洲裔美国人社区建立了成功和密切的伙伴关系，并增加了 在我们的纵向队列和ADRC附属研究和临床试验中代表不足的个人； 和6)丰富的跨学科培训环境，为以下人员提供多方面的教育机会 研究人员、医疗保健提供者和我们的社区合作伙伴。英国-亚洲发展研究中心的总体主题是： 从正常到老年多病因性痴呆的转变。我们的特点很好的纵向队列 和历史上强大的神经病理学计划，专注于正常衰老、临床前疾病状态和早期 认知转变是我们成功定义早期致病机制的核心。 从正常认知老化到功能障碍的转变。此外，这些努力一直是我们 对老年痴呆的异质性和多种病理特征的认识。英国-ADRC 我们将继续利用我们的优势，通过专注于此来增强我们的影响力和“中心性” 总的主题，追求四个总体的具体目标。 目的1.促进和加强AD及相关痴呆的基础、翻译和临床研究。 目标2.提供必要的资源和互动环境，以支持和创造新的机会 用于创新研究。 目标3.保持和发展教育机会和社区伙伴关系，以提高认识， 增加对研究的参与，并提供创新和跨学科的培训环境。 目标4.为国家努力以及与其他中心、方案和团体的协作活动作出贡献 推进AD/ADRD研究、教育和护理。

Project Summary/Abstract: Overall The University of Kentucky Alzheimer’s Disease Research Center (UK-ADRC) is an experienced and collaborative center that has facilitated pioneering research in AD and related dementias (ADRD) since its inception in 1985. Our principal mission is to serve as the focal point for all AD-related activities at UK and this region of the United States, by providing an environment and core resources that catalyze innovative research, outreach, education, and clinical programs. Our signature resources include: 1) a cognitively normal group of ~500 subjects followed longitudinally, together with ~300 additional subjects who transitioned to MCI or dementia, and all committed to brain autopsy upon death; 2) a strong autopsy program with clinical- neuropathological correlations and short postmortem interval research material; 3) a maturing program studying the early preclinical biological emergence of mixed pathologies and how they contribute to late life dementia states, with an increasing focus on antemortem biomarker collection; 4) an integrated centralized database and innovative biostatistical expertise to characterize clinical and biological transitions; 5) a successful and close partnership with the African-American community and increased participation of underrepresented individuals in our longitudinal cohort and ADRC-affiliated research studies and clinical trials; and 6) a rich, interdisciplinary training environment that provides multi-faceted educational opportunities for researchers, healthcare providers, and our community partners. The overarching theme of the UK-ADRC is: Transitions from Normal to Late-Life Multi-Etiology Dementia. Our well-characterized, longitudinal cohort and historically strong neuropathology program focused on normal aging, preclinical disease states and early cognitive transitions have been central to our success in defining early pathogenic mechanisms underlying the transitions from normal cognitive aging to impairment. In addition, these efforts have been a driving force in our recognition of the heterogeneity and multiple pathologies that characterize late-life dementia. The UK-ADRC will continue to leverage our strengths to enhance our impact and “Centerness” by our focus on this overarching theme, and the pursuit of four overall specific aims. Aim 1. Facilitate and enhance basic, translational and clinical research in AD and related dementias. Aim 2. Provide the necessary resources and interactive environment to support and create new opportunities for innovative research. Aim 3. Maintain and grow educational opportunities and community partnerships to promote awareness, increase participation in research, and provide an innovative and interdisciplinary training environment. Aim 4. Contribute to the national efforts and collaborative activities with other centers, programs and groups to advance AD/ADRD research, education, and care.