TRANSFER Neural Underpinnings of Emotion Regulation and Drinking to Cope among Problem Alcohol Drinkers

转移情绪调节和饮酒的神经基础以应对有问题的饮酒者

• 批准号: 10452162
• 负责人: Pilar M Sanjuan
• 金额: $ 14.9万
• 依托单位: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10452162
• 关键词: Alcohol abuse; Alcohol consumption; Alcohols; Amygdaloid structure; Anterior; Area; Arousal; Bioethics; Brain; Chiroptera; Clinical; Cognitive Science; Collection; Computer software; Coping Skills; Coupled; Cues; Data; Data Analyses; Data Set; Development; Development Plans; Dissociation; Distress; Dorsal; Ecological momentary assessment; Educational workshop; Emotional; Emotions; Evaluation; Expressed Emotion; Failure; Feeling; Functional Magnetic Resonance Imaging; Funding; Grant; Hippocampus (Brain); Incidence; Individual; Insula of Reil; Intervention; Judgment; Knowledge; Laboratories; Laboratory Study; Lateral; Life; Light; Link; Literature; Maintenance; Measurement; Measures; Medial; Memory; Mental disorders; Mentors; Methods; Neurons; Neurosciences; Patients; Peripheral Nervous System; Prefrontal Cortex; Process; Psychologist; Psychophysiology; Regulation; Research; Research Methodology; Sampling; Self Assessment; Signal Transduction; Stimulus; Stress; Stressful Event; Structure; Technology Assessment; Time; Training; Training Programs; Treatment outcome; Ventral Striatum; Writing; alcohol craving; alcohol misuse; alcohol research; alcohol use disorder; base; biological adaptation to stress; career development; cognitive neuroscience; craving; design; drinking; emotion regulation; emotional reaction; experience; human subject protection; improved; investigator training; meetings; negative affect; negative emotional state; negative mood; neural network; neuroimaging; neuromechanism; patient oriented research; problem drinker; programs; public health relevance; relating to nervous system; response; secondary analysis; social; symposium

Project Summary/Abstract This Mentored Patient-Oriented Research Career Development application (K23) will provide protected time for Dr. Pilar Sanjuan to develop a focused program of experimental alcohol research and its application to the study of neural mechanisms of emotion regulation underlying alcohol problems. The aims of the 5-year career development plan are tightly integrated and will increase her knowledge and experience in the areas of 1) collecting and analyzing objective neural (fMRI) and psychophysiological emotion regulation data, 2) utilizing advanced quantitative analysis and ecological momentary assessment (EMA) technology for real-time collection of longitudinal data in the field, and 3) grant writing and professional development. The career development plan includes structured meetings with mentors; five graduate level courses in neuroscience, cognitive psychology, and bioethics; and relevant conferences and workshops to develop substantive expertise and training in quantitative/research methods and uses of statistical software. Specific plans are described to consolidate knowledge gains associated with the career development aims through secondary analyses of extant fMRI and EMA data sets. These activities will culminate in the development of an R01 proposal using preliminary data from the associated study in the third and fourth years of the funding period, thus facilitating the transition of Dr. Sanjuan from clinical psychologist to independent neuroscientist. The proposed study will have 3 components and is sequenced to support career development aims: (1) a laboratory-based design to identify emotion regulation and craving neural networks associated with subjective distress and psychophysiological reactivity during emotion regulation in problem drinkers, (2) a field-based design using EMA to determine the relationship of problem drinking with subjective distress, alcohol craving, and drinking to cope, and (3) a lab-to-field analysis to assess the efficacy of laboratory-based neural activation to predict real life craving and drinking to cope measured via EMA. fMRI and psychophysiological assessments will be used to examine neural underpinnings of emotion regulation and EMA methods will be used to examine the real life emotion regulation to drinking to cope relationship. Dr. Eric Claus will be primary mentor and has recognized expertise in cognitive neuroscience, especially alcohol-related neuroimaging. Drs. J. Scott Tonigan and James Gross will serve as secondary mentors supporting the candidate in selected areas including laboratory study of emotion regulation, grant writing, human subjects protections, and data analysis. Drs. Marsha Bates and Matthew Pearson will serve as consultants to assist Dr. Sanjuan to consolidate knowledge gains in applying psychophysiology and EMA methods and analyses in the context of alcohol research.

项目概要/摘要 这个以患者为导向的研究职业发展申请（K23）将为以下人员提供受保护的时间： Pilar Sanjuan 博士将制定一项实验性酒精研究及其应用的重点计划 研究酒精问题背后情绪调节的神经机制。 5年职业生涯的目标 发展计划紧密结合，将增加她在以下领域的知识和经验：1) 收集和分析客观神经 (fMRI) 和心理生理情绪调节数据，2) 利用 先进的实时定量分析和生态瞬时评估（EMA）技术 收集该领域的纵向数据，3) 资助写作和专业发展。职业生涯 发展计划包括与导师的结构化会议；五门神经科学研究生课程， 认知心理学和生物伦理学；以及相关会议和研讨会，以发展实质性专业知识 定量/研究方法和统计软件使用方面的培训。具体计划描述为 通过二次分析，巩固与职业发展目标相关的知识收获 现有的 fMRI 和 EMA 数据集。这些活动最终将导致 R01 提案的制定，使用 资助期第三年和第四年相关研究的初步数据，从而促进 Sanjuan 博士从临床心理学家到独立神经科学家的转变。拟议的研究将 有 3 个组成部分，并按顺序排列以支持职业发展目标：(1) 基于实验室的设计 识别与主观痛苦相关的情绪调节和渴望神经网络 有问题的饮酒者情绪调节过程中的心理生理反应，（2）基于现场的设计 EMA 确定饮酒问题与主观痛苦、酒精渴望以及饮酒的关系 (3) 实验室到现场分析，以评估基于实验室的神经激活预测真实情况的有效性 通过 EMA 测量对生活的渴望和应对饮酒的情况。将使用功能磁共振成像和心理生理学评估 检查情绪调节的神经基础，EMA 方法将用于检查现实生活 情绪调节以饮酒来应对关系。埃里克·克劳斯博士将担任主要导师，并认可 认知神经科学方面的专业知识，特别是与酒精相关的神经影像学。博士。 J·斯科特·托尼根和詹姆斯 格罗斯将担任二级导师，在选定领域为候选人提供支持，包括实验室研究 情绪调节、资助写作、人类受试者保护和数据分析。博士。玛莎·贝茨和 Matthew Pearson 将担任顾问，协助 Sanjuan 博士巩固应用中的知识收获 酒精研究背景下的心理生理学和 EMA 方法和分析。