TRANSFER Neural Underpinnings of Emotion Regulation and Drinking to Cope among Problem Alcohol Drinkers

项目摘要/摘要 这项以患者为导向的指导研究职业发展应用程序(K23)将为 Pilar Sanjuan博士将开发一个有重点的实验酒精研究计划，并将其应用于 酒精问题中情绪调节的神经机制研究。五年职业生涯的目标 发展计划紧密结合，将增加她在1)领域的知识和经验 收集和分析目标神经(FMRI)和心理生理情绪调节数据，2)利用 先进的实时定量分析和生态瞬时评估(EMA)技术 收集实地的纵向数据，以及3)资助写作和职业发展。职业生涯 发展计划包括与导师的有组织的会议；神经科学的五个研究生级别的课程， 认知心理学和生物伦理学；以及发展实质性专门知识的相关会议和讲习班 以及统计软件的量化/研究方法和使用方面的培训。具体计划描述为 通过以下二次分析巩固与职业发展目标相关的知识成果 现有的fMRI和EMA数据集。这些活动将最终制定一份R01建议书，使用 资助期第三年和第四年相关研究的初步数据，从而促进 三娟博士从临床心理学家到独立神经学家的转变。拟议的研究将 有3个组成部分，并按顺序支持职业发展目标：(1)基于实验室的设计，以 识别情绪调节和渴望神经网络与主观痛苦和 问题饮酒者情绪调节过程中的心理生理反应，(2)基于现场的设计 EMA确定问题饮酒与主观苦恼、酒精渴求和饮酒之间的关系 COPE，以及(3)实验室到现场分析，以评估基于实验室的神经激活的有效性，以预测真实 通过EMA测量的生活渴望和饮酒以应对。将使用功能磁共振成像和心理生理学评估 为了检查情绪调节的神经基础，将使用EMA方法来检查现实生活 情绪调节以饮酒应对人际关系。埃里克·克劳斯博士将担任主要导师，并已表彰 在认知神经科学，尤其是与酒精相关的神经成像方面的专业知识。J.Scott Tonigan博士和James 格罗斯将担任辅助导师，在选定的领域支持候选人，包括实验室研究 情绪调节、拨款书写、人类受试者保护和数据分析。玛莎·贝茨博士和 Matthew Pearson将担任顾问，协助Sanjuan博士在应用中巩固知识成果 在酒精研究背景下的心理生理学和EMA方法和分析。

Project Summary/Abstract This Mentored Patient-Oriented Research Career Development application (K23) will provide protected time for Dr. Pilar Sanjuan to develop a focused program of experimental alcohol research and its application to the study of neural mechanisms of emotion regulation underlying alcohol problems. The aims of the 5-year career development plan are tightly integrated and will increase her knowledge and experience in the areas of 1) collecting and analyzing objective neural (fMRI) and psychophysiological emotion regulation data, 2) utilizing advanced quantitative analysis and ecological momentary assessment (EMA) technology for real-time collection of longitudinal data in the field, and 3) grant writing and professional development. The career development plan includes structured meetings with mentors; five graduate level courses in neuroscience, cognitive psychology, and bioethics; and relevant conferences and workshops to develop substantive expertise and training in quantitative/research methods and uses of statistical software. Specific plans are described to consolidate knowledge gains associated with the career development aims through secondary analyses of extant fMRI and EMA data sets. These activities will culminate in the development of an R01 proposal using preliminary data from the associated study in the third and fourth years of the funding period, thus facilitating the transition of Dr. Sanjuan from clinical psychologist to independent neuroscientist. The proposed study will have 3 components and is sequenced to support career development aims: (1) a laboratory-based design to identify emotion regulation and craving neural networks associated with subjective distress and psychophysiological reactivity during emotion regulation in problem drinkers, (2) a field-based design using EMA to determine the relationship of problem drinking with subjective distress, alcohol craving, and drinking to cope, and (3) a lab-to-field analysis to assess the efficacy of laboratory-based neural activation to predict real life craving and drinking to cope measured via EMA. fMRI and psychophysiological assessments will be used to examine neural underpinnings of emotion regulation and EMA methods will be used to examine the real life emotion regulation to drinking to cope relationship. Dr. Eric Claus will be primary mentor and has recognized expertise in cognitive neuroscience, especially alcohol-related neuroimaging. Drs. J. Scott Tonigan and James Gross will serve as secondary mentors supporting the candidate in selected areas including laboratory study of emotion regulation, grant writing, human subjects protections, and data analysis. Drs. Marsha Bates and Matthew Pearson will serve as consultants to assist Dr. Sanjuan to consolidate knowledge gains in applying psychophysiology and EMA methods and analyses in the context of alcohol research.