TRANSFER Neural Underpinnings of Emotion Regulation and Drinking to Cope among Problem Alcohol Drinkers

项目概要/摘要 此指导的以患者为导向的研究职业发展应用程序（K23）将为以下人员提供受保护的时间 博士皮拉尔Sanjuan开发实验酒精研究的重点项目及其在 研究酒精问题背后的情绪调节神经机制。5年职业生涯的目标 发展计划紧密结合，将增加她在以下领域的知识和经验： 收集和分析客观神经（fMRI）和心理生理学情绪调节数据，2）利用 先进的定量分析和生态瞬时评估（EMA）技术， 收集该领域的纵向数据; 3）赠款写作和专业发展。职业 发展计划包括与导师的结构化会议;五个神经科学研究生课程， 认知心理学和生物伦理学;以及相关会议和讲习班，以发展实质性专门知识 以及定量/研究方法和统计软件使用方面的培训。具体计划描述为 通过对职业发展目标的二次分析， 现有的fMRI和EMA数据集。这些活动将最终形成R 01提案， 在资助期的第三和第四年进行的相关研究的初步数据， Sanjuan博士从临床心理学家到独立神经科学家的转变。拟定的研究将 有3个组成部分，并按顺序支持职业发展目标：（1）基于实验室的设计， 识别与主观痛苦相关的情绪调节和渴望神经网络， 问题饮酒者情绪调节过程中的心理生理反应，（2）基于场的设计， EMA以确定问题饮酒与主观痛苦、酒精渴望和饮酒的关系， 科普，以及（3）实验室到现场的分析，以评估基于实验室的神经激活预测真实的 通过EMA测量的生活渴望和饮酒科普。将使用功能磁共振成像和心理生理评估 研究情绪调节的神经基础，EMA方法将用于研究真实的生活 情绪调节到饮酒以科普关系。埃里克·克劳斯博士将担任主要导师， 认知神经科学的专业知识，特别是酒精相关的神经成像。J. Scott Tonigan和James博士 Gross将担任二级导师，在选定的领域为候选人提供支持，包括 情绪调节，拨款写作，人类受试者保护和数据分析。玛莎·贝茨医生和 Matthew Pearson将作为顾问，协助Sanjuan博士巩固申请中的知识收获 心理生理学和EMA方法和分析在酒精研究的背景下。

Project Summary/Abstract This Mentored Patient-Oriented Research Career Development application (K23) will provide protected time for Dr. Pilar Sanjuan to develop a focused program of experimental alcohol research and its application to the study of neural mechanisms of emotion regulation underlying alcohol problems. The aims of the 5-year career development plan are tightly integrated and will increase her knowledge and experience in the areas of 1) collecting and analyzing objective neural (fMRI) and psychophysiological emotion regulation data, 2) utilizing advanced quantitative analysis and ecological momentary assessment (EMA) technology for real-time collection of longitudinal data in the field, and 3) grant writing and professional development. The career development plan includes structured meetings with mentors; five graduate level courses in neuroscience, cognitive psychology, and bioethics; and relevant conferences and workshops to develop substantive expertise and training in quantitative/research methods and uses of statistical software. Specific plans are described to consolidate knowledge gains associated with the career development aims through secondary analyses of extant fMRI and EMA data sets. These activities will culminate in the development of an R01 proposal using preliminary data from the associated study in the third and fourth years of the funding period, thus facilitating the transition of Dr. Sanjuan from clinical psychologist to independent neuroscientist. The proposed study will have 3 components and is sequenced to support career development aims: (1) a laboratory-based design to identify emotion regulation and craving neural networks associated with subjective distress and psychophysiological reactivity during emotion regulation in problem drinkers, (2) a field-based design using EMA to determine the relationship of problem drinking with subjective distress, alcohol craving, and drinking to cope, and (3) a lab-to-field analysis to assess the efficacy of laboratory-based neural activation to predict real life craving and drinking to cope measured via EMA. fMRI and psychophysiological assessments will be used to examine neural underpinnings of emotion regulation and EMA methods will be used to examine the real life emotion regulation to drinking to cope relationship. Dr. Eric Claus will be primary mentor and has recognized expertise in cognitive neuroscience, especially alcohol-related neuroimaging. Drs. J. Scott Tonigan and James Gross will serve as secondary mentors supporting the candidate in selected areas including laboratory study of emotion regulation, grant writing, human subjects protections, and data analysis. Drs. Marsha Bates and Matthew Pearson will serve as consultants to assist Dr. Sanjuan to consolidate knowledge gains in applying psychophysiology and EMA methods and analyses in the context of alcohol research.