TRANSFER Neural Underpinnings of Emotion Regulation and Drinking to Cope among Problem Alcohol Drinkers

转移情绪调节和饮酒的神经基础以应对有问题的饮酒者

• 批准号: 10594117
• 负责人: Pilar M Sanjuan
• 金额: $ 10.72万
• 依托单位: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10594117
• 关键词: Alcohol abuse; Alcohol consumption; Alcohols; Amygdaloid structure; Anterior; Area; Arousal; Bioethics; Brain; Chiroptera; Clinical; Cognitive Science; Collection; Computer software; Coping Skills; Coupled; Cues; Data; Data Analyses; Data Set; Development; Development Plans; Dissociation; Distress; Dorsal; Ecological momentary assessment; Educational workshop; Emotional; Emotions; Evaluation; Expressed Emotion; Failure; Feeling; Functional Magnetic Resonance Imaging; Funding; Grant; Hippocampus (Brain); Incidence; Individual; Insula of Reil; Intervention; Judgment; Knowledge; Laboratories; Laboratory Study; Lateral; Life; Light; Link; Literature; Maintenance; Measurement; Measures; Medial; Memory; Mental disorders; Mentors; Methods; Neurons; Neurosciences; Patients; Peripheral Nervous System; Persons; Prefrontal Cortex; Process; Psychologist; Psychophysiology; Regulation; Research; Research Methodology; Sampling; Self Assessment; Signal Transduction; Stimulus; Stress; Stressful Event; Structure; Technology Assessment; Time; Training; Training Programs; Treatment outcome; Ventral Striatum; Writing; alcohol craving; alcohol misuse; alcohol research; alcohol use disorder; base; biological adaptation to stress; career development; cognitive neuroscience; craving; design; drinking; emotion regulation; emotional reaction; experience; human subject protection; improved; investigator training; meetings; negative affect; negative emotional state; negative mood; neural network; neuroimaging; neuromechanism; patient oriented research; problem drinker; programs; public health relevance; relating to nervous system; response; secondary analysis; social; symposium

Project Summary/Abstract This Mentored Patient-Oriented Research Career Development application (K23) will provide protected time for Dr. Pilar Sanjuan to develop a focused program of experimental alcohol research and its application to the study of neural mechanisms of emotion regulation underlying alcohol problems. The aims of the 5-year career development plan are tightly integrated and will increase her knowledge and experience in the areas of 1) collecting and analyzing objective neural (fMRI) and psychophysiological emotion regulation data, 2) utilizing advanced quantitative analysis and ecological momentary assessment (EMA) technology for real-time collection of longitudinal data in the field, and 3) grant writing and professional development. The career development plan includes structured meetings with mentors; five graduate level courses in neuroscience, cognitive psychology, and bioethics; and relevant conferences and workshops to develop substantive expertise and training in quantitative/research methods and uses of statistical software. Specific plans are described to consolidate knowledge gains associated with the career development aims through secondary analyses of extant fMRI and EMA data sets. These activities will culminate in the development of an R01 proposal using preliminary data from the associated study in the third and fourth years of the funding period, thus facilitating the transition of Dr. Sanjuan from clinical psychologist to independent neuroscientist. The proposed study will have 3 components and is sequenced to support career development aims: (1) a laboratory-based design to identify emotion regulation and craving neural networks associated with subjective distress and psychophysiological reactivity during emotion regulation in problem drinkers, (2) a field-based design using EMA to determine the relationship of problem drinking with subjective distress, alcohol craving, and drinking to cope, and (3) a lab-to-field analysis to assess the efficacy of laboratory-based neural activation to predict real life craving and drinking to cope measured via EMA. fMRI and psychophysiological assessments will be used to examine neural underpinnings of emotion regulation and EMA methods will be used to examine the real life emotion regulation to drinking to cope relationship. Dr. Eric Claus will be primary mentor and has recognized expertise in cognitive neuroscience, especially alcohol-related neuroimaging. Drs. J. Scott Tonigan and James Gross will serve as secondary mentors supporting the candidate in selected areas including laboratory study of emotion regulation, grant writing, human subjects protections, and data analysis. Drs. Marsha Bates and Matthew Pearson will serve as consultants to assist Dr. Sanjuan to consolidate knowledge gains in applying psychophysiology and EMA methods and analyses in the context of alcohol research.

项目总结/文摘

项目成果

Medication for Opioid Use Disorder During Pregnancy - Maternal and Infant Network to Understand Outcomes Associated with Use of Medication for Opioid Use Disorder During Pregnancy (MAT-LINK), 2014-2021.

• DOI: 10.15585/mmwr.ss7203a1
• 发表时间: 2023-05-05
• 期刊: MMWR SURVEILLANCE SUMMARIES
• 影响因子: 24.9
• 作者: Miele, Kathryn;Kim, Shin Y;Jones, Rachelle;Rembert, Juneka H;Wachman, Elisha M;Shrestha, Hira;Henninger, Michelle L;Kimes, Teresa M;Schneider, Patrick D;Sivaloganathan, Vaseekaran;Sward, Katherine A;Deshmukh, Vikrant G;Sanjuan, Pilar M;Maxwell, Jessie R;Seligman, Neil S;Caveglia, Sarah;Louis, Judette M;Wright, Tanner;Bennett, Carolyne Cody;Green, Caitlin;George, Nisha;Gosdin, Lucas;Tran, Emmy L;Meaney-Delman, Dana;Gilboa, Suzanne M
• 通讯作者: Gilboa, Suzanne M

Abnormal target detection and novelty processing neural response in posttraumatic stress disorder.

• DOI: 10.1016/j.pnpbp.2018.04.003
• 发表时间: 2018-07-13
• 期刊: Progress in neuro-psychopharmacology & biological psychiatry
• 影响因子: 5.6
• 作者: Sanjuan PM;Andrews C;Claus ED
• 通讯作者: Claus ED

Prenatal maternal posttraumatic stress disorder as a risk factor for adverse birth weight and gestational age outcomes: A systematic review and meta-analysis.

• DOI: 10.1016/j.jad.2021.08.079
• 发表时间: 2021-12-01
• 期刊: JOURNAL OF AFFECTIVE DISORDERS
• 影响因子: 6.6
• 作者: Sanjuan, Pilar M.;Fokas, Kathryn;Tonigan, J. Scott;Henry, Melissa C.;Christian, Korinna;Rodriguez, Andrea;Larsen, Jessica;Yonke, Nicole;Leeman, Lawrence
• 通讯作者: Leeman, Lawrence

Alcohol and other substance use disorder recovery during pregnancy among patients with posttraumatic stress disorder symptoms: A qualitative study.

• DOI: 10.1016/j.dadr.2021.100013
• 发表时间: 2021-12
• 期刊: Drug and alcohol dependence reports
• 作者: Henry MC;Sanjuan PM;Stone LC;Cairo GF;Lohr-Valdez A;Leeman LM
• 通讯作者: Leeman LM

Best Practices for Engaging Pregnant and Postpartum Women at Risk of Substance Use in Longitudinal Research Studies: a Qualitative Examination of Participant Preferences.

• DOI: 10.1007/s42844-020-00019-1
• 发表时间: 2020
• 期刊: Adversity and resilience science
• 作者: Beasley LO;Ciciolla L;Jespersen JE;Chiaf AL;Schmidt M;Shreffler KM;Breslin FJ;Bakhireva LN;Sanjuan PM;Stephen JM;Coles CD;Chambers CD;Kable JA;Leeman L;Singer LT;Zellner J;Morris AS;Croff JM
• 通讯作者: Croff JM