Impact of Sleep Extension on Insulin Sensitivity and Dietary Intake in Adolescents

延长睡眠对青少年胰岛素敏感性和膳食摄入量的影响

• 批准号: 10450895
• 负责人: Stacey Lynn Simon
• 金额: $ 7.52万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-17 至 2023-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10450895
• 关键词: Address; Adolescence; Adolescent; Adult; Award; Beds; Caring; Childhood; Chronic; Circadian Rhythms; Clinical; Colorado; Complications of Diabetes Mellitus; Coupled; Data; Development; Diabetes Mellitus; Diabetes prevention; Diet; Dietary intake; Eating; Electronics; Elements; Endocrine; Endocrinology; Energy Intake; Expenditure; Fellowship; Functional disorder; Funding; Future; Glucose tolerance test; Goals; Hand; Health; Home; Hour; Insulin; Insulin Resistance; Intervention; Interview; Investigation; K-Series Research Career Programs; Light; Link; Melatonin; Mentors; Mentorship; Metabolic; Metabolic Diseases; Metabolic dysfunction; Metabolism; Methodology; Methods; Modeling; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Parents; Pattern; Pediatric Hospitals; Pediatrics; Perception; Phenotype; Physiological; Pilot Projects; Plasma; Populations at Risk; Prevention; Psychologist; Puberty; Qualitative Methods; Recovery; Reporting; Research; Research Design; Research Personnel; Research Training; Risk; Sampling; School-Age Population; Schools; Scientist; Shapes; Sleep; Sleep Deprivation; Teenagers; Time; Training; Universities; Youth; base; career; circadian; circadian pacemaker; design; diaries; dietary; fasting glucose; high school; improved; insulin secretion; insulin sensitivity; modifiable behavior; novel; obesity in children; obesity risk; obesity treatment; peer; performance tests; prevent; professor; programs; skills; sleep health; sleep onset; social; translational scientist; young man

PROJECT SUMMARY Today’s adolescents habitually obtain well below the recommended 8-10 hours of sleep per night. Insufficient sleep is associated with increased risk of obesity, insulin resistance, and dietary changes and may be contributing to the recent sharp increases in pediatric obesity and type 2 diabetes (T2D). Sleep is therefore a potential novel target for obesity and T2D prevention. However, it is yet unclear whether interventions to extend sleep duration can improve insulin sensitivity and circadian timing of dietary intake, and we lack understanding of sleep health perceptions of adolescents with obesity and T2D. With this career development award, I propose to examine the effect of increased sleep duration on insulin sensitivity and dietary intake in typically short-sleeping adolescents and qualitatively assess sleep perceptions in youth with obesity and T2D. Candidate and Mentors: I am an Assistant Professor of Pediatrics at the University of Colorado and Children’s Hospital Colorado where I am a clinical sleep psychologist focused on research to prevent diabetes and diabetes complications. I completed a research fellowship focused on the effect of sleep restriction on dietary intake, and obtained pilot funding to examine sleep and insulin sensitivity in adolescents with obesity. I have built strong relationships with my mentorship team, which includes co-mentors Dr. Kristen Nadeau (pediatric endocrinology, obesity and diabetes), and Dr. Kenneth Wright (adult sleep health), who will oversee the proposed training and research. Research and Training: I propose short-term scientific, educational, and training goals that can be ideally met with a mentored research award. I will build upon my prior research with three research aims: examine the effect of extending sleep on 1) insulin sensitivity/secretion and 2) circadian timing of dietary intake among adolescents with habitually insufficient sleep, and 3) identify key perceptions, barriers, and facilitators to obtaining sufficient sleep in adolescents with obesity and T2D, to inform the refinement of a sleep extension manipulation in this at-risk population. Complementary training aims include: 1) IVGTT performance and modelling; 2) circadian rhythms; 3) advanced energy intake/expenditure assessment; and 4) qualitative methodology. At award completion, I will have the skills to be a successful independent investigator and will pursue funding to tailor a sleep intervention across the spectrum of metabolic disease aimed at understanding mechanisms in the relationship between sleep, circadian rhythms, and T2D in adolescents. Summary: Sleep is a novel target in the prevention and treatment of obesity and T2D in adolescents. My overall career goal is to develop interventions to improve sleep health in adolescents with a specific goal of preventing progression of sleep-related endocrine and metabolic dysfunction as known precursors to obesity and T2D. Completion of this career development award will support my development into an independent clinical translational investigator and expert scientist in adolescent sleep and metabolism research.

项目摘要 当今的青少年几乎远低于建议每晚8-10个小时的睡眠。不足的 睡眠与肥胖风险增加有关，胰岛素抵抗和饮食变化有关，可能是 促成最近的小儿肥胖和2型糖尿病（T2D）的急剧增加。因此睡眠是一个 肥胖和T2D预防的潜在新型靶标。但是，目前尚不清楚是否干预 延长睡眠时间可以提高胰岛素敏感性和饮食摄入的昼夜节律，我们缺乏 了解肥胖和T2D青少年的睡眠健康感知。随着这种职业发展 奖项，我建议检查睡眠时间增加对胰岛素敏感性和饮食摄入的影响 通常，肥胖和T2D青少年的睡眠感知通常是短暂的青少年。 候选人和导师：我是科罗拉多大学儿科助理教授 我是一名临床睡眠心理学家，致力于预防糖尿病的儿童医院科罗拉多州的儿童医院 和糖尿病并发症。我完成了一项研究奖学金，重点是睡眠限制对 饮食摄入量，并获得了肥胖青少年的睡眠和胰岛素敏感性的试点资金。我 与我的Mentalship团队建立了牢固的关系，其中包括Kristen Nadeau博士 （儿科内分泌学，肥胖和糖尿病）和肯尼斯·赖特（Kenneth Wright）博士（成人睡眠健康），他们将监督 拟议的培训和研究。 研究与培训：我提出了可以实现的短期科学，教育和培训目标 获得指导的研究奖。我将以三个研究的目的为基础我先前的研究：检查 延长睡眠对1）胰岛素敏感性/分泌的作用和2）昼夜节律摄入的时间 几乎睡眠不足的青少年，以及3）确定关键的看法，障碍和促进者 在肥胖和T2D的青少年中获得足够的睡眠，以告知睡眠延伸 在这种高危人群中操纵。补充培训的目的包括：1）IVGTT性能和 造型; 2）昼夜节律； 3）先进的能源摄入/支出评估； 4）定性 方法论。奖励完成后，我将拥有成功的独立研究者的技能，并将 寻求资金来调整旨在理解的代谢疾病范围的睡眠干预措施 青少年睡眠，昼夜节律和T2D之间关系的机制。 摘要：睡眠是预防和治疗青少年肥胖和T2D的新目标。我的 总体职业目标是制定干预措施，以改善青少年的睡眠健康，其特定目标是 防止睡眠相关的内分泌和代谢功能障碍作为肥胖症的已知前体 和T2D。该职业发展奖的完成将支持我成为独立的发展 青少年睡眠和代谢研究的临床转化研究者和专家科学家。