Impact of Sleep Extension on Insulin Sensitivity and Dietary Intake in Adolescents

项目总结 如今的青少年习惯于每晚睡眠时间远低于推荐的8-10小时。不足 睡眠与肥胖、胰岛素抵抗和饮食变化的风险增加有关，并且可能 这是最近儿童肥胖和2型糖尿病(T2D)急剧增加的原因之一。因此，睡眠是一种 潜在的肥胖和T2D预防的新靶点。然而，目前尚不清楚干预是否会 延长睡眠时间可以改善胰岛素敏感性和饮食的昼夜节律，但我们缺乏 肥胖和T2D青少年睡眠健康认知的了解。有了这个职业发展 ，我建议研究睡眠时间增加对胰岛素敏感性和饮食摄入量的影响 通常是睡眠不足的青少年，并定性评估患有肥胖症和T2D的青少年的睡眠感知。 候选人和导师：我是科罗拉多大学的儿科学助理教授， 科罗拉多州儿童医院，我是一名临床睡眠心理学家，专注于预防糖尿病的研究 和糖尿病并发症。我完成了一项研究，重点是睡眠限制对健康的影响 饮食摄入量，并获得试点资金，以检查肥胖青少年的睡眠和胰岛素敏感性。我 我与我的导师团队建立了牢固的关系，其中包括共同导师克里斯汀·纳多博士 (儿科内分泌学、肥胖症和糖尿病)和Kenneth Wright博士(成人睡眠健康)，他们将监督 拟议的培训和研究。 研究和培训：我建议可以理想地实现的短期科学、教育和培训目标 并获得了研究指导奖。我将以我之前的研究为基础，以三个研究目标为基础： 延长睡眠时间对1)胰岛素敏感性/分泌和2)昼夜饮食摄入量的影响 习惯性睡眠不足的青少年，以及3)找出关键的认知、障碍和促进者 在肥胖和T2D青少年中获得足够的睡眠，以通知睡眠延长的改进 在这个高危人群中进行操纵。补充性培训目标包括：1)IVGTT业绩和 建模；2)昼夜节律；3)高级能量摄入/支出评估；以及4)定性 方法论。在奖项完成时，我将拥有成为一名成功的独立调查员的技能，并将 寻求资金，为各种代谢性疾病量身定做睡眠干预措施，旨在了解 青少年睡眠、昼夜节律和T2D之间关系的机制。 摘要：睡眠是预防和治疗青少年肥胖和T2D的新靶点。我的 总的职业目标是开发干预措施，以改善青少年的睡眠健康，具体目标是 防止与睡眠相关的内分泌和代谢功能障碍进展是肥胖的已知先兆 和T2D。完成这个职业发展奖将支持我成为一名独立的 青少年睡眠和新陈代谢研究的临床翻译研究员和专家科学家。

PROJECT SUMMARY Today’s adolescents habitually obtain well below the recommended 8-10 hours of sleep per night. Insufficient sleep is associated with increased risk of obesity, insulin resistance, and dietary changes and may be contributing to the recent sharp increases in pediatric obesity and type 2 diabetes (T2D). Sleep is therefore a potential novel target for obesity and T2D prevention. However, it is yet unclear whether interventions to extend sleep duration can improve insulin sensitivity and circadian timing of dietary intake, and we lack understanding of sleep health perceptions of adolescents with obesity and T2D. With this career development award, I propose to examine the effect of increased sleep duration on insulin sensitivity and dietary intake in typically short-sleeping adolescents and qualitatively assess sleep perceptions in youth with obesity and T2D. Candidate and Mentors: I am an Assistant Professor of Pediatrics at the University of Colorado and Children’s Hospital Colorado where I am a clinical sleep psychologist focused on research to prevent diabetes and diabetes complications. I completed a research fellowship focused on the effect of sleep restriction on dietary intake, and obtained pilot funding to examine sleep and insulin sensitivity in adolescents with obesity. I have built strong relationships with my mentorship team, which includes co-mentors Dr. Kristen Nadeau (pediatric endocrinology, obesity and diabetes), and Dr. Kenneth Wright (adult sleep health), who will oversee the proposed training and research. Research and Training: I propose short-term scientific, educational, and training goals that can be ideally met with a mentored research award. I will build upon my prior research with three research aims: examine the effect of extending sleep on 1) insulin sensitivity/secretion and 2) circadian timing of dietary intake among adolescents with habitually insufficient sleep, and 3) identify key perceptions, barriers, and facilitators to obtaining sufficient sleep in adolescents with obesity and T2D, to inform the refinement of a sleep extension manipulation in this at-risk population. Complementary training aims include: 1) IVGTT performance and modelling; 2) circadian rhythms; 3) advanced energy intake/expenditure assessment; and 4) qualitative methodology. At award completion, I will have the skills to be a successful independent investigator and will pursue funding to tailor a sleep intervention across the spectrum of metabolic disease aimed at understanding mechanisms in the relationship between sleep, circadian rhythms, and T2D in adolescents. Summary: Sleep is a novel target in the prevention and treatment of obesity and T2D in adolescents. My overall career goal is to develop interventions to improve sleep health in adolescents with a specific goal of preventing progression of sleep-related endocrine and metabolic dysfunction as known precursors to obesity and T2D. Completion of this career development award will support my development into an independent clinical translational investigator and expert scientist in adolescent sleep and metabolism research.