District of Columbia Intellectual and Developmental Disabilities Research Center (DC-IDDRC)

哥伦比亚特区智力与发育障碍研究中心 (DC-IDDRC)

基本信息

批准号：
10454190
负责人：
Vittorio Gallo
金额：
$ 138.7万
依托单位：
CHILDREN'S RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-21 至 2026-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10454190
关键词：
Academic Medical Centers Address Animal Model Animals Area Attenuated Basic Science Behavioral Bioinformatics Biological Markers Brain Brain imaging Caring Cells Child Clinical Clinical Research Cognitive Communication Communities Companions Core Facility DNA analysis DNA sequencing Development Developmental Disabilities Disease District of Columbia Doctor of Philosophy Enhancement Technology Environment Evaluation Family Future Genetic Diseases Genomics Goals Grant Growth Home Hospitals Human Image Analysis Imaging Device Imaging technology Individual Innovative Therapy Institution Intellectual and Developmental Disabilities Research Centers Intellectual functioning disability Interdisciplinary Study International Intervention Investigation Laboratories Lead Learning Link Mental Health Messenger RNA Microscopy Mission Molecular Neonatal Brain Injury Neurobehavioral Manifestations Neurodevelopmental Disorder Neurosciences Optics Outcome Measure Pathology Pilot Projects Play Postdoctoral Fellow Prevention approach Prevention strategy Research Research Personnel Research Project Grants Research Support Resources Role Science Scientist Statistical Data Interpretation Strategic Planning Structure Sum Technology Testing Therapeutic Tissues Training Training and Education Translating Translational Research Universities Washington Youth animal imaging behavioral phenotyping bench to bedside cellular imaging clinical development clinical outcome measures cohesion community based participatory research comorbidity cost effective design effective therapy fetal flexibility fundamental research health disparity human imaging image processing improved in vivo innovation investigator training molecular imaging neurobehavioral neurodevelopment neuroimaging novel novel diagnostics novel therapeutics pre-clinical prevent programs quality assurance recruit research data dissemination response success supportive environment synergism tool training opportunity treatment strategy

项目摘要

The mission of the DC-IDDRC is to expand our understanding of the causes underlying intellectual and developmental disabilities (IDDs), develop innovative therapies, and prevent or attenuate the full effects of these disorders, so that each child can achieve her/his full physical and intellectual potential. To realize this mission, we provide a rich environment for performing fully translational IDDR in the four collaborating DC academic medical centers (Children’s National Hospital (lead), George Washington University, Howard University, and Georgetown University). Our specific aims are: 1) To identify the causes and develop new clinical approaches for the prevention or amelioration of IDDs; 2) To provide accessible, state-of-the-art,cost- effective core facilities for cohesive, multidisciplinary research and education/training in IDDR; 3) To create an intellectual home for investigators engaged in IDDR; and 4) To implement an innovative Research Project that addresses two IDDR themes (Interventions and Management of Co-morbid Mental Health Conditions; Outcome Measures or Biomarkers for Interventions or Treatments). The DC-IDDRC Director, Vittorio Gallo, PhD, is an internationally renowned neuroscientist who will direct the Administrative Core that functions as the organizing nexus of the DC-IDDRC, providing management, administration, communication and training, assuring compliance and quality assurance, directing strategic planning and recruitment, and promoting the growth of the DC-IDDRC. The scientific cores provide an integrated platform and synergy for investigation, as required by truly translational IDDR. The Clinical Translational Core (CTC) is designed to serve as a “one- stop-shop” for IDDR investigators, assisting at each stage of the clinical and translational research spectrum and optimizing the efficient, high quality implementation of fundamental research. The Genomics and Bioinformatics Core (GBC) provides advanced genomics technologies and specialized statistical analyses for DNA and mRNA studies. The Cell and Tissue Microscopy Core (CTMC) supports investigators with a broad array of advanced cellular/molecular imaging tools for state-of-the-art neuroscience studies. The Human and Animal Imaging Core (HAIC) provides scientific and technical support for in vivo/ex vivo whole brain imaging, image processing, and image analysis for human and animal studies. The Neurobehavioral Evaluation Core (NEC) provides sophisticated neurobehavioral research support to define developmental and behavioral phenotypes in humans and animals. Our project “Intervention-induced plasticity of flexibility and learning mechanisms in ASD” utilizes the CTC, HAIC and NEC. Through these components, the DC- IDDRC will enhance the recruitment and training of investigators, generate innovation, and promote transdisciplinary research to facilitate the development, implementation, and dissemination of new diagnostic and therapeutic advances for the care of individuals with IDDs.

DC-IDDRC的使命是扩展我们对智力基本原因的理解和发育障碍（IDD），开发创新疗法，并预防或减轻这些疾病，以便每个孩子都能实现她/他的全部身体和智力潜力。意识到这一点任务，我们提供了一个丰富的环境，用于在四个合作的DC中进行完全翻译的IDDR 学术医疗中心（儿童国家医院（LEAD），乔治华盛顿大学，霍华德大学和乔治敦大学）。我们的具体目的是：1）确定原因并发展新的原因预防或改善IDD的临床方法； 2）提供可访问的最先进的成本 - IDDR中有凝聚力，多学科研究和教育/培训的有效核心设施； 3）创建从事IDDR的调查人员的知识分子； 4）实施一个创新的研究项目这涉及两个IDDR主题（干预和合并心理健康状况的管理；进行干预或治疗的结果指标或生物标志物）。 DC-IDDRC导演Vittorio Gallo，博士是国际知名的神经科学家 DC-IDDRC的组织联系，提供管理，管理，沟通和培训，确保合规性和质量保证，指导战略规划和招聘，并促进 DC-IDDRC的生长。科学核心为投资提供了集成的平台和协同作用，根据真正翻译的IDDR的要求。临床翻译核心（CTC）旨在用作“一个 IDDR调查人员的暂停商店”，在临床和翻译研究范围的每个阶段协助并优化基本研究的高效，高质量实施。基因组学和生物信息学核心（GBC）提供高级基因组技术和专业统计分析用于DNA和mRNA研究。细胞和组织显微镜核心（CTMC）支持研究者用于最先进的神经科学研究的广泛的晚期细胞/分子成像工具。这人类和动物成像核心（HAIC）为体内/外体提供了科学和技术支持人类和动物研究的脑成像，图像处理和图像分析。神经行为评估核心（NEC）提供了复杂的神经行为研究支持，以定义发展和人类和动物的行为表型。我们的项目“干预引起的灵活性可塑性 ASD中的学习机制使用CTC，HAIC和NEC。通过这些组件，DC- IDDRC将增强调查人员的招聘和培训，产生创新并促进跨学科研究以支持新诊断的开发，实施和传播以及护理IDD的人的治疗进步。