District of Columbia Intellectual and Developmental Disabilities Research Center (DC-IDDRC)

哥伦比亚特区智力与发育障碍研究中心 (DC-IDDRC)

• 批准号: 10454190
• 负责人: Vittorio Gallo
• 金额: $ 138.7万
• 依托单位: CHILDREN'S RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-21 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10454190
• 关键词: Academic Medical Centers; Address; Animal Model; Animals; Area; Attenuated; Basic Science; Behavioral; Bioinformatics; Biological Markers; Brain; Brain imaging; Caring; Cells; Child; Clinical; Clinical Research; Cognitive; Communication; Communities; Companions; Core Facility; DNA analysis; DNA sequencing; Development; Developmental Disabilities; Disease; District of Columbia; Doctor of Philosophy; Enhancement Technology; Environment; Evaluation; Family; Future; Genetic Diseases; Genomics; Goals; Grant; Growth; Home; Hospitals; Human; Image Analysis; Imaging Device; Imaging technology; Individual; Innovative Therapy; Institution; Intellectual and Developmental Disabilities Research Centers; Intellectual functioning disability; Interdisciplinary Study; International; Intervention; Investigation; Laboratories; Lead; Learning; Link; Mental Health; Messenger RNA; Microscopy; Mission; Molecular; Neonatal Brain Injury; Neurobehavioral Manifestations; Neurodevelopmental Disorder; Neurosciences; Optics; Outcome Measure; Pathology; Pilot Projects; Play; Postdoctoral Fellow; Prevention approach; Prevention strategy; Research; Research Personnel; Research Project Grants; Research Support; Resources; Role; Science; Scientist; Statistical Data Interpretation; Strategic Planning; Structure; Sum; Technology; Testing; Therapeutic; Tissues; Training; Training and Education; Translating; Translational Research; Universities; Washington; Youth; animal imaging; behavioral phenotyping; bench to bedside; cellular imaging; clinical development; clinical outcome measures; cohesion; community based participatory research; comorbidity; cost effective; design; effective therapy; fetal; flexibility; fundamental research; health disparity; human imaging; image processing; improved; in vivo; innovation; investigator training; molecular imaging; neurobehavioral; neurodevelopment; neuroimaging; novel; novel diagnostics; novel therapeutics; pre-clinical; prevent; programs; quality assurance; recruit; research data dissemination; response; success; supportive environment; synergism; tool; training opportunity; treatment strategy

The mission of the DC-IDDRC is to expand our understanding of the causes underlying intellectual and developmental disabilities (IDDs), develop innovative therapies, and prevent or attenuate the full effects of these disorders, so that each child can achieve her/his full physical and intellectual potential. To realize this mission, we provide a rich environment for performing fully translational IDDR in the four collaborating DC academic medical centers (Children’s National Hospital (lead), George Washington University, Howard University, and Georgetown University). Our specific aims are: 1) To identify the causes and develop new clinical approaches for the prevention or amelioration of IDDs; 2) To provide accessible, state-of-the-art,cost- effective core facilities for cohesive, multidisciplinary research and education/training in IDDR; 3) To create an intellectual home for investigators engaged in IDDR; and 4) To implement an innovative Research Project that addresses two IDDR themes (Interventions and Management of Co-morbid Mental Health Conditions; Outcome Measures or Biomarkers for Interventions or Treatments). The DC-IDDRC Director, Vittorio Gallo, PhD, is an internationally renowned neuroscientist who will direct the Administrative Core that functions as the organizing nexus of the DC-IDDRC, providing management, administration, communication and training, assuring compliance and quality assurance, directing strategic planning and recruitment, and promoting the growth of the DC-IDDRC. The scientific cores provide an integrated platform and synergy for investigation, as required by truly translational IDDR. The Clinical Translational Core (CTC) is designed to serve as a “one- stop-shop” for IDDR investigators, assisting at each stage of the clinical and translational research spectrum and optimizing the efficient, high quality implementation of fundamental research. The Genomics and Bioinformatics Core (GBC) provides advanced genomics technologies and specialized statistical analyses for DNA and mRNA studies. The Cell and Tissue Microscopy Core (CTMC) supports investigators with a broad array of advanced cellular/molecular imaging tools for state-of-the-art neuroscience studies. The Human and Animal Imaging Core (HAIC) provides scientific and technical support for in vivo/ex vivo whole brain imaging, image processing, and image analysis for human and animal studies. The Neurobehavioral Evaluation Core (NEC) provides sophisticated neurobehavioral research support to define developmental and behavioral phenotypes in humans and animals. Our project “Intervention-induced plasticity of flexibility and learning mechanisms in ASD” utilizes the CTC, HAIC and NEC. Through these components, the DC- IDDRC will enhance the recruitment and training of investigators, generate innovation, and promote transdisciplinary research to facilitate the development, implementation, and dissemination of new diagnostic and therapeutic advances for the care of individuals with IDDs.

DC-IDDRC的使命是扩大我们对潜在的智力和 发育性残疾(IDDS)，开发创新疗法，预防或减轻 这些障碍，使每个儿童都能充分发挥她/他的身体和智力潜力。要认识到这一点 使命，我们为在四个协作DC中执行完全翻译的iDDR提供了丰富的环境 学术医疗中心(儿童国家医院(LEAD)、乔治华盛顿大学、霍华德 大学和乔治城大学)。我们的具体目标是：1)找准原因，发展新的 预防或改善IDDS的临床方法；2)提供可获得的、最先进的、成本- 有效的核心设施，促进综合、多学科的研究和教育/培训；3)建立 为从事iDDR的研究人员提供智力之家；以及4)实施创新研究项目 它涉及两个iDDR主题(共病心理健康状况的干预和管理； 干预或治疗的结果衡量或生物标记物)。DC-IDDRC主任维托里奥·加洛， 博士是一位国际知名的神经学家，他将领导行政核心，其职能是 DC-IDDRC的组织关系，提供管理、行政、沟通和培训， 确保合规和质量保证，指导战略规划和招聘，并促进 DC-IDDRC的成长。科学核心为调查提供了一个综合平台和协同作用， 正如真正的翻译iDDR所要求的那样。临床翻译核心(CTC)被设计为一个“一个-- 为iDDR研究人员提供一站式服务，在临床和转化性研究的每个阶段提供协助 优化高效、高质量实施基础研究。基因组学和 生物信息学核心(GBC)提供先进的基因组学技术和专业的统计分析 用于DNA和mRNA研究。细胞和组织显微镜核心(CTMC)为研究人员提供支持 广泛的先进细胞/分子成像工具，用于最先进的神经科学研究。这个 人与动物成像核心(HAIC)为体内/体外整体提供科学技术支持 用于人类和动物研究的脑成像、图像处理和图像分析。神经行为 评估核心(NEC)提供复杂的神经行为研究支持，以定义发展 以及人类和动物的行为表型。我们的项目《干预诱导的灵活性的可塑性》 ASD中的学习机制“利用了CTC、HAIC和NEC。通过这些组件，DC- 国际发展研究中心将加强对调查人员的招聘和培训，产生创新，促进 跨学科研究，以促进新诊断的开发、实施和传播 以及对IDDS患者的护理方面的治疗进展。