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District of Columbia Intellectual and Developmental Disabilities Research Center (DC-IDDRC)

哥伦比亚特区智力与发育障碍研究中心 (DC-IDDRC)

基本信息

批准号：
10237679
负责人：
Vittorio Gallo
金额：
$ 139.32万
依托单位：
CHILDREN'S RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-21 至 2026-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10237679
关键词：
Academic Medical Centers Address Animal Model Animals Area Attenuated Basic Science Behavioral Bioinformatics Biological Markers Brain Brain imaging Caring Cells Child Clinical Clinical Research Cognitive Communication Communities Companions Core Facility DNA analysis DNA sequencing Development Developmental Disabilities Disease District of Columbia Doctor of Philosophy Enhancement Technology Environment Evaluation Family Future Gap Junctions Genetic Diseases Genomics Goals Grant Growth Home Hospitals Human Image Analysis Imaging Device Imaging technology Individual Innovative Therapy Institution Intellectual and Developmental Disabilities Research Centers Intellectual functioning disability Interdisciplinary Study International Intervention Investigation Laboratories Lead Learning Link Mental Health Messenger RNA Microscopy Mission Molecular Neonatal Brain Injury Neurobehavioral Manifestations Neurodevelopmental Disorder Neurosciences Optics Outcome Measure Pathology Pilot Projects Play Postdoctoral Fellow Prevention approach Prevention strategy Research Research Personnel Research Project Grants Research Support Resources Role Science Scientist Statistical Data Interpretation Strategic Planning Structure Sum Technology Testing Therapeutic Tissues Training Training and Education Translating Translational Research Universities Washington Youth animal imaging behavioral phenotyping bench to bedside cellular imaging clinical development clinical outcome measures cohesion community based participatory research comorbidity cost effective design effective therapy fetal flexibility fundamental research health disparity human imaging image processing improved in vivo innovation investigator training molecular imaging neurobehavioral neurodevelopment neuroimaging novel novel diagnostics novel therapeutics pre-clinical prevent programs quality assurance recruit research data dissemination response success supportive environment synergism tool training opportunity treatment strategy

项目摘要

The mission of the DC-IDDRC is to expand our understanding of the causes underlying intellectual and developmental disabilities (IDDs), develop innovative therapies, and prevent or attenuate the full effects of these disorders, so that each child can achieve her/his full physical and intellectual potential. To realize this mission, we provide a rich environment for performing fully translational IDDR in the four collaborating DC academic medical centers (Children’s National Hospital (lead), George Washington University, Howard University, and Georgetown University). Our specific aims are: 1) To identify the causes and develop new clinical approaches for the prevention or amelioration of IDDs; 2) To provide accessible, state-of-the-art,cost- effective core facilities for cohesive, multidisciplinary research and education/training in IDDR; 3) To create an intellectual home for investigators engaged in IDDR; and 4) To implement an innovative Research Project that addresses two IDDR themes (Interventions and Management of Co-morbid Mental Health Conditions; Outcome Measures or Biomarkers for Interventions or Treatments). The DC-IDDRC Director, Vittorio Gallo, PhD, is an internationally renowned neuroscientist who will direct the Administrative Core that functions as the organizing nexus of the DC-IDDRC, providing management, administration, communication and training, assuring compliance and quality assurance, directing strategic planning and recruitment, and promoting the growth of the DC-IDDRC. The scientific cores provide an integrated platform and synergy for investigation, as required by truly translational IDDR. The Clinical Translational Core (CTC) is designed to serve as a “one- stop-shop” for IDDR investigators, assisting at each stage of the clinical and translational research spectrum and optimizing the efficient, high quality implementation of fundamental research. The Genomics and Bioinformatics Core (GBC) provides advanced genomics technologies and specialized statistical analyses for DNA and mRNA studies. The Cell and Tissue Microscopy Core (CTMC) supports investigators with a broad array of advanced cellular/molecular imaging tools for state-of-the-art neuroscience studies. The Human and Animal Imaging Core (HAIC) provides scientific and technical support for in vivo/ex vivo whole brain imaging, image processing, and image analysis for human and animal studies. The Neurobehavioral Evaluation Core (NEC) provides sophisticated neurobehavioral research support to define developmental and behavioral phenotypes in humans and animals. Our project “Intervention-induced plasticity of flexibility and learning mechanisms in ASD” utilizes the CTC, HAIC and NEC. Through these components, the DC- IDDRC will enhance the recruitment and training of investigators, generate innovation, and promote transdisciplinary research to facilitate the development, implementation, and dissemination of new diagnostic and therapeutic advances for the care of individuals with IDDs.

DC-IDDRC 的使命是加深我们对知识和文化背后原因的理解。发育障碍（IDD），开发创新疗法，并预防或减弱发育障碍的全部影响这些疾病，以便每个孩子都能充分发挥其身体和智力潜力。为了实现这一点使命，我们为在四个合作 DC 中执行完全转化 IDDR 提供丰富的环境学术医疗中心（儿童国家医院（牵头）、乔治华盛顿大学、霍华德大学和乔治城大学）。我们的具体目标是： 1）找出原因并开发新的预防或改善 IDD 的临床方法； 2) 提供可访问的、最先进的、成本低廉的 IDDR 领域内有凝聚力的多学科研究和教育/培训的有效核心设施； 3）创建为 IDDR 调查人员提供知识之家； 4) 实施创新研究项目涉及两个 IDDR 主题（共病心理健康状况的干预和管理；干预或治疗的结果测量或生物标志物）。 DC-IDDRC 主任 Vittorio Gallo，博士是一位国际知名的神经科学家，他将领导行政核心，其职能是 DC-IDDRC 的组织关系，提供管理、行政、沟通和培训，确保合规性和质量保证，指导战略规划和招聘，并促进 DC-IDDRC 的发展。科学核心为调查提供了一个综合平台和协同作用，按照真正的平移 IDDR 的要求。临床转化核心 (CTC) 旨在充当“单一为 IDDR 研究人员提供一站式服务，在临床和转化研究的每个阶段提供协助优化基础研究高效、高质量实施。基因组学和生物信息学核心 (GBC) 提供先进的基因组学技术和专业的统计分析用于 DNA 和 mRNA 研究。细胞和组织显微镜核心 (CTMC) 支持研究人员用于最先进的神经科学研究的一系列先进的细胞/分子成像工具。这人类和动物成像核心（HAIC）为体内/离体整体提供科学技术支持用于人类和动物研究的脑成像、图像处理和图像分析。神经行为学评估核心 (NEC) 提供复杂的神经行为研究支持来定义发育以及人类和动物的行为表型。我们的项目“干预引起的灵活性可塑性 ASD 中的学习机制”利用了 CTC、HAIC 和 NEC。通过这些组件，DC- IDDRC将加强调查人员的招募和培训，激发创新，促进跨学科研究，促进新诊断方法的开发、实施和传播以及 IDD 患者护理方面的治疗进展。