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District of Columbia Intellectual and Developmental Disabilities Research Center (DC-IDDRC)

哥伦比亚特区智力与发育障碍研究中心 (DC-IDDRC)

基本信息

批准号：
10237679
负责人：
Vittorio Gallo
金额：
$ 139.32万
依托单位：
CHILDREN'S RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-21 至 2026-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10237679
关键词：
Academic Medical Centers Address Animal Model Animals Area Attenuated Basic Science Behavioral Bioinformatics Biological Markers Brain Brain imaging Caring Cells Child Clinical Clinical Research Cognitive Communication Communities Companions Core Facility DNA analysis DNA sequencing Development Developmental Disabilities Disease District of Columbia Doctor of Philosophy Enhancement Technology Environment Evaluation Family Future Gap Junctions Genetic Diseases Genomics Goals Grant Growth Home Hospitals Human Image Analysis Imaging Device Imaging technology Individual Innovative Therapy Institution Intellectual and Developmental Disabilities Research Centers Intellectual functioning disability Interdisciplinary Study International Intervention Investigation Laboratories Lead Learning Link Mental Health Messenger RNA Microscopy Mission Molecular Neonatal Brain Injury Neurobehavioral Manifestations Neurodevelopmental Disorder Neurosciences Optics Outcome Measure Pathology Pilot Projects Play Postdoctoral Fellow Prevention approach Prevention strategy Research Research Personnel Research Project Grants Research Support Resources Role Science Scientist Statistical Data Interpretation Strategic Planning Structure Sum Technology Testing Therapeutic Tissues Training Training and Education Translating Translational Research Universities Washington Youth animal imaging behavioral phenotyping bench to bedside cellular imaging clinical development clinical outcome measures cohesion community based participatory research comorbidity cost effective design effective therapy fetal flexibility fundamental research health disparity human imaging image processing improved in vivo innovation investigator training molecular imaging neurobehavioral neurodevelopment neuroimaging novel novel diagnostics novel therapeutics pre-clinical prevent programs quality assurance recruit research data dissemination response success supportive environment synergism tool training opportunity treatment strategy

项目摘要

The mission of the DC-IDDRC is to expand our understanding of the causes underlying intellectual and developmental disabilities (IDDs), develop innovative therapies, and prevent or attenuate the full effects of these disorders, so that each child can achieve her/his full physical and intellectual potential. To realize this mission, we provide a rich environment for performing fully translational IDDR in the four collaborating DC academic medical centers (Children’s National Hospital (lead), George Washington University, Howard University, and Georgetown University). Our specific aims are: 1) To identify the causes and develop new clinical approaches for the prevention or amelioration of IDDs; 2) To provide accessible, state-of-the-art,cost- effective core facilities for cohesive, multidisciplinary research and education/training in IDDR; 3) To create an intellectual home for investigators engaged in IDDR; and 4) To implement an innovative Research Project that addresses two IDDR themes (Interventions and Management of Co-morbid Mental Health Conditions; Outcome Measures or Biomarkers for Interventions or Treatments). The DC-IDDRC Director, Vittorio Gallo, PhD, is an internationally renowned neuroscientist who will direct the Administrative Core that functions as the organizing nexus of the DC-IDDRC, providing management, administration, communication and training, assuring compliance and quality assurance, directing strategic planning and recruitment, and promoting the growth of the DC-IDDRC. The scientific cores provide an integrated platform and synergy for investigation, as required by truly translational IDDR. The Clinical Translational Core (CTC) is designed to serve as a “one- stop-shop” for IDDR investigators, assisting at each stage of the clinical and translational research spectrum and optimizing the efficient, high quality implementation of fundamental research. The Genomics and Bioinformatics Core (GBC) provides advanced genomics technologies and specialized statistical analyses for DNA and mRNA studies. The Cell and Tissue Microscopy Core (CTMC) supports investigators with a broad array of advanced cellular/molecular imaging tools for state-of-the-art neuroscience studies. The Human and Animal Imaging Core (HAIC) provides scientific and technical support for in vivo/ex vivo whole brain imaging, image processing, and image analysis for human and animal studies. The Neurobehavioral Evaluation Core (NEC) provides sophisticated neurobehavioral research support to define developmental and behavioral phenotypes in humans and animals. Our project “Intervention-induced plasticity of flexibility and learning mechanisms in ASD” utilizes the CTC, HAIC and NEC. Through these components, the DC- IDDRC will enhance the recruitment and training of investigators, generate innovation, and promote transdisciplinary research to facilitate the development, implementation, and dissemination of new diagnostic and therapeutic advances for the care of individuals with IDDs.

DC-IDDRC的使命是扩大我们对智力和疾病背后的原因的理解