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Training Program in Personalized Cardiovascular Medicine (TPIPCVM)

个性化心血管医学培训计划 (TPIPCVM)

基本信息

批准号：
10454147
负责人：
Dawood Darbar
金额：
$ 40.29万
依托单位：
UNIVERSITY OF ILLINOIS AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-07-01 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10454147
关键词：
Cardiovascular system Medicine Training Programs

项目摘要

TRAINING IN PERSONALIZED CARDIOVASCULAR MEDICINE (TPIPCVM) Project Summary Cardiovascular disease (CVD) remains a major cause for significant morbidity and mortality in the U.S. especially in ethnic minorities with their high burden of risk factors. Personalized medicine is a rapidly growing field of healthcare whereby an individual's unique genomic, environmental and clinical background is analyzed to ascertain susceptibility to disease, predict their clinical course and tailor specific therapies. Despite recent advances in CV genomics, our inability to target therapy to underlying mechanisms in individual patients, the failure to translate these scientific discoveries to the bedside care of patients and barriers to the incorporation of ethnic minorities in translational CV research have limited our ability to fulfill the promise of personalized medicine. Furthermore, traditional training programs are no longer able to provide trainees with the requisite skills needed to implement the personalized medicine revolution underway. Thereby, major goals of the Training Program in Personalized Cardiovascular Medicine (TPIPCVM) are to equip trainees to become leaders in CV Genomics and be trained in molecular, cellular, disease and whole animal modeling and clinical and translational approaches to CVD so that this new knowledge can be translated into best evidence-based personalized CV care. We will recruit highly talented and motivated pre- and post-doctoral trainees and provide them with the highest caliber training in CV genomics stemming from existing strengths of our faculty in the Division of Cardiology and our partners at UIC. The 3 Research Focus Groups: 1) Cardiac arrhythmias; 2) Ischemic and non-ischemic cardiomyopathy; and CVD-related metabolic syndrome are highly interrelated with each other and directly linked with the central theme of Personalized CV Genomics. The overarching goal of the TPIPCVM is to train the next generation of CV investigators to create new knowledge and implement into best evidence-based personalized medicine. The TPIPCVM mentors are highly successful physician-scientists/scientists with a proven record of research, mentoring and collaboration who offer superb inter- and multi- disciplinary training opportunities. Major strengths of this training program include: exposure of trainees to an integrated basic science molecular, cellular, and whole patient approach to identify the underlying mechanisms of CVD; the track record of the faculty and their common research interest in Personalized CV Genomics; dedicated training in personalized CV medicine; and the potential to implement scientific discoveries to a diverse and under-represented population of patients cared for at UIC Medical Center. The TPIPCVM sets out to train 2 pre-doctoral and 2 post-doctoral students annually. Collectively, this Training Program offers a unique training experience and fulfills an urgent need for training in personalized CV medicine.

个体化心血管医学培训（tpipcvm）

项目成果

期刊论文数量（20）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Nicotinamide restores tissue NAD+ and improves survival in rodent models of cardiac arrest.

DOI：
10.1371/journal.pone.0291598
发表时间：
2023
期刊：
PloS one
影响因子：
3.7
作者：
通讯作者：

Trained immunity of alveolar macrophages enhances injury resolution via KLF4-MERTK-mediated efferocytosis.

DOI：
10.1084/jem.20221388
发表时间：
2023-11-06
期刊：
The Journal of experimental medicine
影响因子：
0
作者：
通讯作者：

Mutant ANP induces mitochondrial and ion channel remodeling in a human iPSC-derived atrial fibrillation model.

DOI：
10.1172/jci.insight.155640
发表时间：
2022-04-08
期刊：
JCI INSIGHT
影响因子：
8
作者：
Ly, Olivia T.;Chen, Hanna;Brown, Grace E.;Hong, Liang;Wang, Xinge;Han, Yong Duk;Pavel, Mahmud Arif;Sridhar, Arvind;Maienschein-Cline, Mark;Chalazan, Brandon;Ong, Sang-Ging;Abdelhady, Khaled;Massad, Malek;Rizkallah, Lona Ernst;Rehman, Jalees;Khetani, Salman R.;Darbar, Dawood
通讯作者：
Darbar, Dawood

Coronary arterial vasculature in the pathophysiology of hypertrophic cardiomyopathy.

肥厚性心肌病的病理生理学中的冠状动脉血管。