Training Program in Personalized Cardiovascular Medicine (TPIPCVM)

个性化心血管医学培训(TPIPCVM) 项目摘要 心血管疾病(CVD)仍然是导致老年人严重发病率和死亡率的主要原因。 在美国，尤其是少数民族，他们的风险因素负担很高。个性化医疗是一种 快速增长的医疗保健领域，个人独特的基因组、环境和临床 背景分析是为了确定疾病的易感性，预测他们的临床病程和量身定做 特定的疗法。尽管最近在心血管基因组学方面取得了进展，但我们无法针对 个体患者的潜在机制，未能将这些科学发现转化为 患者的床边护理和将少数族裔纳入翻译简历的障碍 研究限制了我们实现个性化医疗承诺的能力。此外， 传统的培训计划不再能够为学员提供必要的技能 实施正在进行的个性化医疗革命。因此，培训的主要目标是 个性化心血管医学计划(TPIPCVM)旨在使学员成为 在心血管基因组学方面处于领先地位，并接受过分子、细胞、疾病和整体动物建模方面的培训 以及心血管疾病的临床和翻译方法，以便将这些新知识转化为 最好的循证个性化简历护理。我们将招聘非常有才华和上进心的预科和 博士后实习生，并为他们提供最高水平的CV基因组学干源培训 来自我们心脏科教员和我们在UIC的合作伙伴的现有优势。三人组 研究重点：1)心律失常；2)缺血性和非缺血性心肌病；以及 心血管疾病相关的代谢综合征相互之间高度相关，并与 个性化简历基因组学的中心主题。TPIPCVM的总体目标是培训 新一代简历调查人员创造新知识，并以最佳证据为基础 个性化医疗。TPIPCVM导师是非常成功的医生-科学家/科学家 拥有久经考验的研究、指导和合作记录，提供卓越的跨部门和多方面的 纪律培训机会。这一培训计划的主要优势包括：暴露 受训人员学习分子、细胞和整个患者的综合基础科学方法，以识别 心血管疾病的潜在机制；教职员工的记录和他们共同的研究兴趣 个性化心血管基因组学；个性化心血管医学方面的专门培训；以及 将科学发现应用于多样化和代表性不足的患者群体，这些患者在 UIC医疗中心。TPIPCVM计划培养2名博士后和2名博士后 每年一次。总体而言，该培训计划提供了独特的培训体验，并满足了 需要进行个性化简历医学方面的培训。

TRAINING IN PERSONALIZED CARDIOVASCULAR MEDICINE (TPIPCVM) Project Summary Cardiovascular disease (CVD) remains a major cause for significant morbidity and mortality in the U.S. especially in ethnic minorities with their high burden of risk factors. Personalized medicine is a rapidly growing field of healthcare whereby an individual's unique genomic, environmental and clinical background is analyzed to ascertain susceptibility to disease, predict their clinical course and tailor specific therapies. Despite recent advances in CV genomics, our inability to target therapy to underlying mechanisms in individual patients, the failure to translate these scientific discoveries to the bedside care of patients and barriers to the incorporation of ethnic minorities in translational CV research have limited our ability to fulfill the promise of personalized medicine. Furthermore, traditional training programs are no longer able to provide trainees with the requisite skills needed to implement the personalized medicine revolution underway. Thereby, major goals of the Training Program in Personalized Cardiovascular Medicine (TPIPCVM) are to equip trainees to become leaders in CV Genomics and be trained in molecular, cellular, disease and whole animal modeling and clinical and translational approaches to CVD so that this new knowledge can be translated into best evidence-based personalized CV care. We will recruit highly talented and motivated pre- and post-doctoral trainees and provide them with the highest caliber training in CV genomics stemming from existing strengths of our faculty in the Division of Cardiology and our partners at UIC. The 3 Research Focus Groups: 1) Cardiac arrhythmias; 2) Ischemic and non-ischemic cardiomyopathy; and CVD-related metabolic syndrome are highly interrelated with each other and directly linked with the central theme of Personalized CV Genomics. The overarching goal of the TPIPCVM is to train the next generation of CV investigators to create new knowledge and implement into best evidence-based personalized medicine. The TPIPCVM mentors are highly successful physician-scientists/scientists with a proven record of research, mentoring and collaboration who offer superb inter- and multi- disciplinary training opportunities. Major strengths of this training program include: exposure of trainees to an integrated basic science molecular, cellular, and whole patient approach to identify the underlying mechanisms of CVD; the track record of the faculty and their common research interest in Personalized CV Genomics; dedicated training in personalized CV medicine; and the potential to implement scientific discoveries to a diverse and under-represented population of patients cared for at UIC Medical Center. The TPIPCVM sets out to train 2 pre-doctoral and 2 post-doctoral students annually. Collectively, this Training Program offers a unique training experience and fulfills an urgent need for training in personalized CV medicine.