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Directly measuring synaptic and population coupling in cortex during perception

直接测量感知过程中皮层的突触和群体耦合

基本信息

批准号：
10453553
负责人：
Bilal Haider
金额：
$ 39.91万
依托单位：
GEORGIA INSTITUTE OF TECHNOLOGY
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-07-01 至 2024-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10453553
关键词：
Action Potentials Address Anesthesia procedures Automobile Driving Behavior Behavioral Biophysical Process Brain Cells Cerebral cortex Characteristics Communication Complex Coupling Dementia Detection Development Disease Epilepsy Equilibrium Exhibits Goals Impairment Individual Knowledge Lead Mammals Measurement Measures Membrane Potentials Modeling Mus Neurodevelopmental Disorder Neurologic Neurons Outcome Parvalbumins Perception Performance Population Positioning Attribute Process Research Resolution Rewards Schizophrenia Sensory Sensory Process Signal Detection Analysis Signal Transduction Silicon Site Stimulus Structure Synapses Techniques Validation Visual Visual Cortex Visual Perception Visuospatial Withdrawal Work area striata autism spectrum disorder awake density effective therapy excitatory neuron experimental study inhibitory neuron innovation nervous system disorder neural network optogenetics patch clamp response spatiotemporal theories visual stimulus

项目摘要

Directly measuring synaptic and population coupling in cortex during perception The cerebral cortex is the defining brain structure of mammals and underlies our most complex sensory behaviors. A major need exists to identify how synaptic and network mechanisms in cortex lead to normal and impaired sensory perception and behavior. A prevailing model of cortical function postulates that synaptic excitation (E) and inhibition (I) exhibit a stable balance (E/I balance) that is disrupted during sensory impairments and neurodevelopmental diseases. Currently, there is no knowledge regarding synaptic E/I balance during sensory perception, nor its relationship to large-scale neural network activity. We are uniquely positioned to bridge this critical knowledge gap with an innovative combination of whole-cell patch-clamp and large-scale population recordings of defined excitatory and inhibitory neurons during visual perception in mice. This multi- scale approach will enable us to 1) Define how excitatory and inhibitory neuron populations spanning cortical layers predict the accuracy of visual perception 2) Reveal synaptic mechanisms that underlie visual perception 3) Define the relationship between excitatory and inhibitory population activity and synaptic mechanisms engaged by visual perception. SIGNIFICANCE. This project will meet a significant need to understand how excitatory and inhibitory activity in cortex is coordinated at the synaptic, network, and behavioral levels to support sensory perception. It is imperative to understand these processes in individual neurons, networks, and their synaptic inputs during behavior, so that we may better comprehend how to rectify sensory processing deficits characteristic of many neurological and neurodevelopmental disorders. INNOVATION. This project will provide innovative measurements and analysis of the relationship between single-neuron synaptic inputs and large-scale neural network activity during controlled perceptual behaviors. This combination of techniques will allow critical assessment of long-standing theories of cortical function (E/I balance) that require validation in relevant behavioral contexts. These results will provide conceptual innovation by detailing how inhibition sculpts and coordinates excitatory activity in cortex to orchestrate perceptual behaviors.

直接测量感知过程中皮层突触和种群的耦合

项目成果

期刊论文数量（5）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Spatial modulation of dark versus bright stimulus responses in the mouse visual system.

DOI：
10.1016/j.cub.2021.06.094
发表时间：
2021-09-27
期刊：
Current biology : CB
影响因子：
0
作者：
Williams B;Del Rosario J;Muzzu T;Peelman K;Coletta S;Bichler EK;Speed A;Meyer-Baese L;Saleem AB;Haider B
通讯作者：
Haider B

Probing mechanisms of visual spatial attention in mice.

DOI：
10.1016/j.tins.2021.07.009
发表时间：
2021-10
期刊：
Trends in neurosciences
影响因子：
15.9
作者：
Speed A;Haider B
通讯作者：
Haider B

Cortical State Fluctuations across Layers of V1 during Visual Spatial Perception.

视觉空间感知过程中 V1 层的皮质状态波动。

DOI：
10.1016/j.celrep.2019.02.045
发表时间：
2019
期刊：
Cell reports
影响因子：
8.8
作者：
Speed,Anderson;DelRosario,Joseph;Burgess,ChristopherP;Haider,Bilal
通讯作者：
Haider,Bilal

Optimizing intact skull intrinsic signal imaging for subsequent targeted electrophysiology across mouse visual cortex.

DOI：
10.1038/s41598-022-05932-2
发表时间：
2022-02-08
期刊：
Scientific reports
影响因子：
4.6
作者：
Nsiangani A;Del Rosario J;Yeh AC;Shin D;Wells S;Lev-Ari T;Williams B;Haider B
通讯作者：
Haider B