UAB Childhood Cystic Kidney Disease Core Center (UAB-CCKDCC) - In Vivo Bioassay and Model Development Resource
UAB Childhood Cystic Kidney Disease Core Center (UAB-CCKDCC) - In Vivo Bioassay and Model Development Resource
批准号:
10686003
负责人:
Bradley K. Yoder
金额:
$14.53万
依托单位国家:
美国
项目类别:
财政年份:
2020
资助国家:
美国
项目状态:
未结题
起止时间:
2020-07-20 至 2025-06-30
关键词:
AccelerationAddressAffectAllelesAnimal Disease ModelsAnimal ModelAnimalsAutosomal Dominant Polycystic KidneyAutosomal Recessive Polycystic KidneyBardet-Biedl SyndromeBasic ScienceBiocompatible MaterialsBiologicalBiosensorCategoriesCell modelCellsChildhoodCiliaClinicalClinical DataClinical TrialsClustered Regularly Interspaced Short Palindromic RepeatsCollaborationsComplementCyclic AMPCystCystic Kidney DiseasesCystic kidneyDataDefectDevelopmentDiseaseDisease PathwayDisease modelEngineeringFRAP1 geneFunctional disorderFutureGenerationsGenesGenetic ModelsGrowthHomeHumanHuman EngineeringIn VitroIndividualInstitutionKidneyKidney DiseasesMacrophageMeasuresMeckel-Gruber syndromeMissense MutationMissionModelingMorphologyMusMutationNational Institute of Diabetes and Digestive and Kidney DiseasesNephronophthisisOrganismOutcomePathogenesisPathogenicityPathologyPathway interactionsPatientsPharmaceutical PreparationsPilot ProjectsPolycystic Kidney DiseasesProteinsRattusReagentReporterReproducibilityResearchResearch ActivityResearch PersonnelResource DevelopmentResourcesSTAT3 geneSamplingSensoryServicesSignal PathwaySignal TransductionSiteStandardizationSyndromeSystemTailTestingTherapeuticTrainingTranslational ResearchUncertaintyVisionWorkbiobankcost effectivedata repositoryeffective therapyeffectiveness evaluationefficacy evaluationimprovedin vitro Bioassayin vivoin vivo Bioassayin vivo imaginginnovationintravital imagingmembermodel developmentmultidisciplinarymutantnovelnovel therapeuticspre-clinicalprotein functionprotein purificationresponsescreeningserial imagingtherapeutic developmenttherapeutic evaluationtreatment strategy
中文摘要
摘要(核心C)
UAB儿童囊性肾病核心中心(UAB-CCKDCC)的主要使命是与
PKD联合体在U24中央协调站(U24-CCS)和NIDDK的指导下,
消除囊性肾病研究中阻碍开发进展的障碍
改善治疗策略。UAB-CCKDCC组建了一个多学科研究团队,
指导四个紧密集成的资源和面向服务的核心沿着管理核心。的
这些核心的集体使命是支持、加速和扩大PKD的基础研究和转化研究
联盟成员通过提供CCKD患者的临床数据和生物材料,
CCKD患者相关细胞和动物模型的开发和分布,以分析致病性
参与囊肿发生和进展的机制,并通过发展精简,成本-
为PKD联盟提供有效的管道,以快速确定新药减缓囊肿生长的功效。
UAB-CCKDCC中的体内生物测定和模型开发资源(核心C)的任务是
用于CCKD相关的动物模型、体内生物传感器和报告系统的产生和分发
途径和从这些模型产生的生物试剂。待开发的模型包括生物传感器
研究CCKD和动物模型中涉及的信号通路所需的多种生物体中的报告基因
用于基于数据生成的具有人类患者突变的广泛CCKD综合征
从UAB-CCKDCC的核心A和整个PKD联盟获得。核心C也将维持一个银行
从这些模型中提取生物材料进行分配,以促进试点研究,快速测试新的假设。最后,
由核心C产生和维护的广泛的CCKD和报告系统将很容易制造
可供PKD联盟用于在UAB-CCKDCC核心D中进行的临床前试验,以评价
候选疗法采用高度标准化、成本效益高的纵向成像和创新分析
战略布局核心C提供的服务和资源及其与其他核心的集成
在UAB-CCKDCC中,将扩展研究活动,超出大多数单个实验室的能力,
通过提供高质量、稳健和可重复的结果,加速对可能的治疗方法的研究,
因此,迫切需要优先考虑未来临床试验的药物,以阻止PKD和其他囊性肾病。
英文摘要
ABSTRACT (CORE C)
The primary mission of the UAB-Childhood Cystic Kidney Disease Core Center (UAB-CCKDCC) is to work with
the PKD Consortium, under the direction of the U24 Central Coordinating Site (U24-CCS) and NIDDK, to
eliminate obstacles in cystic kidney disease research that are slowing progress toward the development of
improved treatment strategies. The UAB-CCKDCC has assembled a multidisciplinary team of researchers that
direct four tightly integrated resource and service-oriented Cores along with an Administrative Core. The
collective mission of these Cores is to support, accelerate, and expand basic and translational research by PKD
Consortium members by providing access to clinical data and biomaterial from CCKD patients, through the
development and distribution of patient-relevant cell and animal models of CCKD to analyze pathogenic
mechanisms involved in cyst initiation and progression, and through the development of streamlined, cost-
effective pipelines for the PKD Consortium to rapidly ascertain the efficacy of new drugs to slow cyst growth.
The In Vivo Bioassay and Model Development Resource (Core C) within the UAB-CCKDCC is tasked
with generating and distributing animal models, in vivo biosensors and reporter systems for CCKD associated
pathways, and biological reagents generated from these models. Models to be developed include biosensors
and reporters in multiple organisms needed to study signaling pathways involved in CCKD and animal models
for a wide range of CCKD syndromes with human patient mutations that will be generated based on data
obtained in Core A in the UAB-CCKDCC and from the overall PKD Consortium. Core C will also maintain a bank
of biomaterials from these models for distribution to promote pilot studies to rapidly test new hypotheses. Finally,
the wide spectrum of CCKD and reporter systems generated and maintained by Core C will be made readily
available to PKD Consortium for preclinical trails being conducted in Core D of the UAB-CCKDCC to evaluate
candidate therapies using highly standardized, cost-effective, and longitudinal imaging and innovative analysis
strategies. The services and resources being made available by Core C and it’s integration with the other Cores
in the UAB-CCKDCC will expand research activities beyond what is capable in most individual labs and will
accelerate research into possible cures by providing for high quality, robust, and reproducible outcomes that are
critically needed to prioritize drugs for future clinical trials to halt PKD and other cystic kidney disorders.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Injury Response Mediated Pathogenesis in Renal Ciliopathies
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批准号:10571152
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项目类别:
-
资助金额:$52.32万
-
财政年份:2023
-
负责人:Bradley K. Yoder
-
依托单位:
UAB Pilot Center for Precision Animal Modeling (C-PAM) - Coordination Section
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批准号:10477302
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项目类别:
-
资助金额:$11.55万
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财政年份:2020
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负责人:Bradley K. Yoder
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依托单位:
Intravital analysis of cilia function during injury in the kidney
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批准号:10391576
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项目类别:
-
资助金额:$4.22万
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财政年份:2020
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负责人:Bradley K. Yoder
-
依托单位:
Intravital analysis of cilia function during injury in the kidney
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批准号:10507035
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项目类别:
-
资助金额:$6.57万
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财政年份:2020
-
负责人:Bradley K. Yoder
-
依托单位:
UAB Childhood Cystic Kidney Disease Core Center (UAB-CCKDCC) - Administrative Core
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批准号:10685972
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项目类别:
-
资助金额:$32.27万
-
财政年份:2020
-
负责人:Bradley K. Yoder
-
依托单位:
UAB Childhood Cystic Kidney Disease Core Center (UAB-CCKDCC)
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批准号:10685971
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项目类别:
-
资助金额:$78.67万
-
财政年份:2020
-
负责人:Bradley K. Yoder
-
依托单位:
UAB Childhood Cystic Kidney Disease Core Center (UAB-CCKDCC)
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批准号:10455717
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项目类别:
-
资助金额:$76.89万
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财政年份:2020
-
负责人:Bradley K. Yoder
-
依托单位:
UAB Childhood Cystic Kidney Disease Core Center (UAB-CCKDCC) - In Vivo Bioassay and Model Development Resource
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批准号:10455721
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项目类别:
-
资助金额:$32.12万
-
财政年份:2020
-
负责人:Bradley K. Yoder
-
依托单位:
Intravital analysis of cilia function during injury in the kidney
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批准号:10722377
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项目类别:
-
资助金额:$3.02万
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财政年份:2020
-
负责人:Bradley K. Yoder
-
依托单位:
Intravital analysis of cilia function during injury in the kidney
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批准号:10310430
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项目类别:
-
资助金额:$38.79万
-
财政年份:2020
-
负责人:Bradley K. Yoder
-
依托单位:
UAB Childhood Cystic Kidney Disease Core Center (UAB-CCKDCC) - In Vivo Bioassay and Model Development Resource
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批准号:10218164
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项目类别:
-
资助金额:$16.25万
-
财政年份:2020
-
负责人:Bradley K. Yoder
-
依托单位:
UAB Childhood Cystic Kidney Disease Core Center (UAB-CCKDCC) - Administrative Core
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批准号:10455718
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项目类别:
-
资助金额:$15.15万
-
财政年份:2020
-
负责人:Bradley K. Yoder
-
依托单位:
UAB Pilot Center for Precision Animal Modeling (C-PAM) - Coordination Section
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批准号:10260615
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项目类别:
-
资助金额:$11.55万
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财政年份:2020
-
负责人:Bradley K. Yoder
-
依托单位:
UAB Childhood Cystic Kidney Disease Core Center (UAB-CCKDCC)
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批准号:10455818
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项目类别:
-
资助金额:$20.69万
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财政年份:2020
-
负责人:Bradley K. Yoder
-
依托单位:
UAB Childhood Cystic Kidney Disease Core Center (UAB-CCKDCC)
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批准号:10058125
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项目类别:
-
资助金额:$81.09万
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财政年份:2020
-
负责人:Bradley K. Yoder
-
依托单位:
UAB Childhood Cystic Kidney Disease Core Center (UAB-CCKDCC)
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批准号:10218159
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项目类别:
-
资助金额:$79.74万
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财政年份:2020
-
负责人:Bradley K. Yoder
-
依托单位:
UAB Childhood Cystic Kidney Disease Core Center (UAB-CCKDCC) - Administrative Core
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批准号:10218160
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项目类别:
-
资助金额:$15.76万
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财政年份:2020
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负责人:Bradley K. Yoder
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依托单位:
Intravital analysis of cilia function during injury in the kidney
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批准号:10527348
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项目类别:
-
资助金额:$38.79万
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财政年份:2020
-
负责人:Bradley K. Yoder
-
依托单位:
UAB Childhood Cystic Kidney Disease Core Center (UAB-CCKDCC)
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批准号:10892542
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项目类别:
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资助金额:$18.04万
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财政年份:2020
-
负责人:Bradley K. Yoder
-
依托单位:
UAB Childhood Cystic Kidney Disease Core Center (UAB-CCKDCC) - Administrative Core
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批准号:10910435
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项目类别:
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资助金额:$18.04万
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财政年份:2020
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负责人:Bradley K. Yoder
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依托单位:
海外基金