Scientific Core

科学核心-摘要摘要 我们P50临床研究中心的科学核心建立在共享的悠久历史之上 伊顿-皮博迪实验室的基础设施，由三个研究核心组成 Pi Liberman：1)设计、构建、编程和维护数据采集的工程核心 系统、定制声学设备和刺激产生系统，以提供精确度 提供机械加工服务，为客户定制各种机械设备进行研究 应用程序，并与更多的科学工作者分享这些软件和硬件的进步 社区；2)组织学-外科核心，用于维护和储备共享的湿法实验室设施 组织学处理和共享动物外科设施，以及受控物质 许可，对新用户进行组织学和外科技术培训，并不断提高 整个中心的组织准备质量；以及3)需要维护的影像核心 并就共用共焦显微镜和荧光显微镜对用户进行培训，并支持数字化 图像采集和分析，通过商业软件包，或在必要时，通过 创建自定义软件，以实现形态测量和三维重建的进一步自动化 和渲染。 核心的公共性质提供了许多重大好处，包括：1) 加强集团间沟通，2)提供规模经济，3)消除重复 工作包括维护独立的基于调查员的设施，4)帮助调查人员 在分享技术专长的基础上，将新的方法纳入其保留剧目 跨研究人员和学科，以及5)允许创建共享硬件和 软件系统的功能远远超出了在 与世隔绝。

Scientific Core – Summary Abstract The Scientific Core of our P50 Clinical Research Center builds on the long history of shared infrastructure at the Eaton-Peabody Laboratories, and consists of three Research Cores led by PI Liberman: 1) an Engineering Core to design, build, program and maintain data-acquisition systems, custom acoustical devices, and stimulus generation systems, to provide a precision machining service to build custom mechanical devices for a wide variety of research applications, and to share these software and hardware advances with the greater scientific community; 2) a Histology-Surgery Core to maintain and stock a shared wet-lab facility for histological processing and shared animal-surgery facilities, along with controlled substance licensure, to train new users on histological and surgical techniques and to continually enhance the quality of histological preparation throughout the Center; and 3) an Imaging Core to maintain and train users on the shared confocal and epifluoresence microscopes, and to support digital image-acquisition and analysis, via commercial software packages or, when necessary, via creation of custom software to allow further automation of morphometry and 3-D reconstruction and rendering. The communal nature of the Cores provide a number of significant benefits including: 1) enhancing inter-group communication, 2) providing economy of scale, 3) eliminating duplication of effort involved maintaining separate Investigator-based facilities, 4) helping investigators incorporate new approaches into their repertoire, based on the sharing of technical expertise across researchers and disciplines, and 5) allowing the creation of shared hardware and software systems with capabilities far beyond that achievable by individual PIs working in isolation.