NIDCD National Temporal Bone Hearing and Balance Pathology Resource Registry

NIDCD 国家颞骨听力和平衡病理学资源登记处

• 批准号: 10673034
• 负责人: M. Charles Liberman
• 金额: $ 76.66万
• 依托单位: MASSACHUSETTS EYE AND EAR INFIRMARY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10673034
• 关键词: Algorithms; Archival Collection; Autopsy; Cessation of life; Collection; Confocal Microscopy; DNA; Data; Databases; Development; Diagnosis; Disease; Doctor of Medicine; Doctor of Philosophy; Education; Education and Outreach; Enrollment; Equilibrium; Evaluation; Facial nerve structure; Gene Expression; Hearing; Hearing problem; Histologic; Histopathology; Human; Image; Immunofluorescence Immunologic; Label; Laboratories; Life; Magnetic Resonance Imaging; Maintenance; Medical History; Medical Records; Medicine; Methodology; Methods; Microscopy; Mission; Modality; Modernization; Molecular Genetics; National Institute on Deafness and Other Communication Disorders; Organ Procurements; Pathologic; Pathology; Physicians; Principal Investigator; Process; Proteomics; Registries; Research; Research Personnel; Resources; Scientist; Specialist; Specimen; Techniques; Temporal bone structure; experience; human subject; imaging approach; improved; interest; member; preservation; programs; recruit; searchable database; synchrotron radiation

Project Summary A comprehensive program is proposed to facilitate 1) recruitment of human temporal bone donors, 2) accrual and distribution of donated specimens to active laboratories, 3) development and maintenance of searchable de-identified databases including diagnoses, histopathological summaries, audiometric data and complete sets of digitized images, 4) brokering of special needs of research investigators using human otologic material, and 5) educational efforts including educational outreach to the public and interested professionals including scientists and organ procurement specialists and undertakers. As has been the case for the last 26 years, this will be accomplished through the maintenance and enhancement of a coordinated Temporal Bone Registry Office. The proposed Registry function will be overseen by Felipe Santos, M.D. (Principal Investigator) with assistance from Alicia Quesnel, M.D. (Co-Prinicpal Investigator) and M. Charles Liberman, Ph.D. (Co- Principal Investigator). Additional input will be solicited from other Departmental members with experience and professional interest in furtherance of human temporal bone histopathology, including D. Bradley Welling, M.D., Ph.D and Joseph B. Nadol, M.D. Additional oversight will be provided by the NIDCD Program Coordinator for the Registry who will help in the selection of a Steering Committee including the PI of the Registry, the Project Coordinator and 2 to 3 external scientists with an understanding and appreciation of the value of otopathology and basic otologic research.

项目摘要 一项全面的计划被提出，以促进人类颞骨的招募 捐赠者，2)获得捐赠标本并将其分发给活跃的实验室，3)开发 以及维护可搜索的未识别数据库，包括诊断、组织病理学 摘要、听力数据和成套数字化图像，4)经纪特别节目 使用人类耳科材料的研究人员的需求，以及5)教育努力 包括面向公众和感兴趣的专业人士的教育推广活动，包括科学家和 器官采购专家和承办人。就像过去26年来的情况一样，这 将通过维护和加强协调的时间 骨骼登记处。拟议的登记处职能将由菲利佩·桑托斯医学博士监督。 (首席调查员)由艾丽西亚·奎斯奈尔(医学博士)(联合印联调查员)和 M.Charles Liberman，博士(联合首席调查员)。将从以下位置征求其他意见 其他在促进人权方面有经验和专业兴趣的部门成员 颞骨组织病理学，包括D.Bradley Wling，M.D.，Ph.D.和Joseph B.Nadol， 医学博士。 书记官处的NIDCD方案协调员将提供额外的监督 将帮助选择一个指导委员会，包括书记官处、项目 协调员和2至3名外部科学家，了解和欣赏 耳病理学和基础耳科学研究。

项目成果

Assessing fractional hair cell survival in archival human temporal bones.

评估档案人类颞骨中毛细胞的存活率。

• DOI: 10.1002/lary.27991
• 发表时间: 2020
• 期刊: The Laryngoscope
• 作者: Wu,Pei-Zhe;Wen,Wei-Ping;O'Malley,JenniferT;Liberman,MCharles
• 通讯作者: Liberman,MCharles

Peripheral Vestibular Organ Degeneration After Temporal Bone Fracture: A Human Otopathology Study.

颞骨骨折后周围前庭器官退化：人类耳病理学研究。

• DOI: 10.1002/lary.28010
• 发表时间: 2020
• 期刊: The Laryngoscope
• 作者: Knoll,RenataM;Ishai,Reuven;Lubner,RoryJ;Trakimas,DanielleR;Brodsky,JacobR;Jung,DavidH;Rauch,StevenD;NadolJr.,,JosephB;Remenschneider,AaronK;Kozin,ElliottD
• 通讯作者: Kozin,ElliottD

Histopathological changes to the peripheral vestibular system following meningitic labyrinthitis.

脑膜迷路炎后周围前庭系统的组织病理学变化。

• DOI: 10.1002/lio2.349
• 发表时间: 2020
• 期刊: Laryngoscope investigative otolaryngology
• 影响因子: 1.9
• 作者: Pauna,HenriqueF;Knoll,RenataM;Lubner,RoryJ;Brodsky,JacobR;Cushing,SharonL;Hyppolito,MiguelA;NadolJr,JosephB;Remenschneider,AaronK;Kozin,ElliottD
• 通讯作者: Kozin,ElliottD

Human Otopathologic Findings in Cases of Folded Cochlear Implant Electrodes.

折叠人工耳蜗植入电极病例中的人类耳病理学发现。

• DOI: 10.1097/mao.0000000000001886
• 发表时间: 2018
• 期刊: Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
• 作者: Trakimas,DanielleR;Kozin,ElliottD;Ghanad,Iman;NadolJr,JosephB;Remenschneider,AaronK
• 通讯作者: Remenschneider,AaronK

Histopathology of the Inner Ear in a Case With Recent Onset of Cogan's Syndrome: Evidence for Vasculitis.

近期发生科根综合征的内耳组织病理学：血管炎的证据。

• DOI: 10.1177/0003489415595426
• 发表时间: 2016
• 期刊: The Annals of otology, rhinology, and laryngology
• 作者: Jung,DavidH;NadolJr,JosephB;Folkerth,RebeccaD;Merola,JosephF
• 通讯作者: Merola,JosephF