NIDCD National Temporal Bone Hearing and Balance Pathology Resource Registry

NIDCD 国家颞骨听力和平衡病理学资源登记处

• 批准号: 10239103
• 负责人: M. Charles Liberman
• 金额: $ 70.77万
• 依托单位: MASSACHUSETTS EYE AND EAR INFIRMARY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10239103
• 关键词: Algorithms; Archives; Autopsy; Cessation of life; Collection; Confocal Microscopy; DNA; Data; Databases; Development; Diagnosis; Disease; Doctor of Medicine; Doctor of Philosophy; Enrollment; Equilibrium; Evaluation; Facial nerve structure; Gene Expression; Hearing; Hearing problem; Histologic; Histopathology; Human; Image; Immunofluorescence Immunologic; Label; Laboratories; Life; Magnetic Resonance Imaging; Maintenance; Medical History; Medical Records; Medicine; Methodology; Methods; Microscopy; Mission; Modality; Modernization; Molecular Genetics; National Institute on Deafness and Other Communication Disorders; Organ Procurements; Pathologic; Pathology; Physicians; Principal Investigator; Process; Proteomics; Registries; Research; Research Personnel; Resources; Scientist; Specialist; Specimen; Techniques; Temporal bone structure; experience; human subject; imaging approach; improved; interest; member; outreach; preservation; programs; recruit; searchable database; synchrotron radiation

Project Summary A comprehensive program is proposed to facilitate 1) recruitment of human temporal bone donors, 2) accrual and distribution of donated specimens to active laboratories, 3) development and maintenance of searchable de-identified databases including diagnoses, histopathological summaries, audiometric data and complete sets of digitized images, 4) brokering of special needs of research investigators using human otologic material, and 5) educational efforts including educational outreach to the public and interested professionals including scientists and organ procurement specialists and undertakers. As has been the case for the last 26 years, this will be accomplished through the maintenance and enhancement of a coordinated Temporal Bone Registry Office. The proposed Registry function will be overseen by Felipe Santos, M.D. (Principal Investigator) with assistance from Alicia Quesnel, M.D. (Co-Prinicpal Investigator) and M. Charles Liberman, Ph.D. (Co- Principal Investigator). Additional input will be solicited from other Departmental members with experience and professional interest in furtherance of human temporal bone histopathology, including D. Bradley Welling, M.D., Ph.D and Joseph B. Nadol, M.D. Additional oversight will be provided by the NIDCD Program Coordinator for the Registry who will help in the selection of a Steering Committee including the PI of the Registry, the Project Coordinator and 2 to 3 external scientists with an understanding and appreciation of the value of otopathology and basic otologic research.

项目总结