NIDCD National Temporal Bone Hearing and Balance Pathology Resource Registry

项目概要 提出了一项综合计划，以促进 1) 人类颞骨的募集 捐赠者，2) 向活跃实验室捐赠样本的累积和分配，3) 开发 和维护可搜索的去识别化数据库，包括诊断、组织病理学 摘要、听力数据和完整的数字化图像，4) 特殊服务的经纪 研究人员使用人体耳科材料的需求，以及 5) 教育工作 包括向公众和感兴趣的专业人士（包括科学家和 器官获取专家和承办商。与过去 26 年的情况一样， 将通过维护和增强协调的时间来完成 骨登记处。拟议的登记职能将由医学博士 Felipe Santos 监督。 （首席研究员）在医学博士 Alicia Quesnel（联合首席研究员）的协助下 M.查尔斯·利伯曼博士（联合首席研究员）。将征求更多意见 其他在促进人类发展方面具有经验和专业兴趣的部门成员 颞骨组织病理学，包括 D. Bradley Welling，医学博士、博士和 Joseph B. Nadol， 医学博士 NIDCD 项目协调员将为登记处提供额外的监督， 将帮助选择指导委员会，包括注册管理机构的 PI、项目 协调员和 2 至 3 名外部科学家，了解并欣赏其价值 耳病理学和基础耳科研究。

Project Summary A comprehensive program is proposed to facilitate 1) recruitment of human temporal bone donors, 2) accrual and distribution of donated specimens to active laboratories, 3) development and maintenance of searchable de-identified databases including diagnoses, histopathological summaries, audiometric data and complete sets of digitized images, 4) brokering of special needs of research investigators using human otologic material, and 5) educational efforts including educational outreach to the public and interested professionals including scientists and organ procurement specialists and undertakers. As has been the case for the last 26 years, this will be accomplished through the maintenance and enhancement of a coordinated Temporal Bone Registry Office. The proposed Registry function will be overseen by Felipe Santos, M.D. (Principal Investigator) with assistance from Alicia Quesnel, M.D. (Co-Prinicpal Investigator) and M. Charles Liberman, Ph.D. (Co- Principal Investigator). Additional input will be solicited from other Departmental members with experience and professional interest in furtherance of human temporal bone histopathology, including D. Bradley Welling, M.D., Ph.D and Joseph B. Nadol, M.D. Additional oversight will be provided by the NIDCD Program Coordinator for the Registry who will help in the selection of a Steering Committee including the PI of the Registry, the Project Coordinator and 2 to 3 external scientists with an understanding and appreciation of the value of otopathology and basic otologic research.