NIDCD National Temporal Bone Hearing and Balance Pathology Resource Registry

项目摘要 提出了一个综合方案，以促进1）招募人颞骨 捐赠者，2）捐赠标本的累积和分发到活跃的实验室，3）开发 和维护可搜索的去识别数据库，包括诊断、组织病理学 摘要、测听数据和整套数字化图像，4） 研究人员使用人类耳科材料的需求，以及5）教育工作 包括对公众和包括科学家在内的感兴趣的专业人员进行教育宣传， 器官获取专家和生物学家在过去的26年里， 将通过维护和加强协调的时间 骨登记办公室。拟议的书记官处职能将由Felipe桑托斯医学博士监督。 （主要研究者）在Alicia Quesnel，M.D.的协助下（共同主要研究者）和 M. Charles Liberman博士(Co-首席研究员）。将征求以下方面的补充意见： 其他在促进人类发展方面具有经验和专业兴趣的部门成员 颞骨组织病理学，包括D.医学博士布拉德利·威林，博士和约瑟夫B。纳多尔， M.D. 登记处的NIDCD计划协调员将提供额外的监督， 将有助于选择一个指导委员会，包括注册处的PI， 协调员和2至3名外部科学家，了解和欣赏 耳科病理学和基础耳科研究。

Project Summary A comprehensive program is proposed to facilitate 1) recruitment of human temporal bone donors, 2) accrual and distribution of donated specimens to active laboratories, 3) development and maintenance of searchable de-identified databases including diagnoses, histopathological summaries, audiometric data and complete sets of digitized images, 4) brokering of special needs of research investigators using human otologic material, and 5) educational efforts including educational outreach to the public and interested professionals including scientists and organ procurement specialists and undertakers. As has been the case for the last 26 years, this will be accomplished through the maintenance and enhancement of a coordinated Temporal Bone Registry Office. The proposed Registry function will be overseen by Felipe Santos, M.D. (Principal Investigator) with assistance from Alicia Quesnel, M.D. (Co-Prinicpal Investigator) and M. Charles Liberman, Ph.D. (Co- Principal Investigator). Additional input will be solicited from other Departmental members with experience and professional interest in furtherance of human temporal bone histopathology, including D. Bradley Welling, M.D., Ph.D and Joseph B. Nadol, M.D. Additional oversight will be provided by the NIDCD Program Coordinator for the Registry who will help in the selection of a Steering Committee including the PI of the Registry, the Project Coordinator and 2 to 3 external scientists with an understanding and appreciation of the value of otopathology and basic otologic research.