Center for comprehensive proteogenomic data analysis
综合蛋白质组数据分析中心
基本信息
- 批准号:10644013
- 负责人:
- 金额:$ 77.53万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-06-15 至 2027-05-31
- 项目状态:未结题
- 来源:
- 关键词:AffectAffinityAlgorithmic AnalysisAlgorithmsAntigen TargetingBig DataBiochemicalBioinformaticsBiologicalBiological ModelsCancer BiologyClinicalCollaborationsCollectionComplexComputational BiologyCopy Number PolymorphismDataData AnalysesData CommonsData SetDatabasesDecision AidDecision MakingDifferentiation AntigensDiseaseDoseDrug TargetingDrug resistanceEncapsulatedFoundationsGenesGeneticGenomeGenomicsHLA AntigensHumanImmuneIndividualLeadershipLigaseMalignant NeoplasmsMapsMass Spectrum AnalysisMeasurementMethodologyMethodsModelingMultiomic DataMutateMutationPathway AnalysisPathway interactionsPeptidesPharmaceutical PreparationsPharmacotherapyPhasePhosphotransferasesPost Translational Modification AnalysisPost-Translational Modification SitePost-Translational Protein ProcessingProcessPrognostic MarkerProteinsProteomeProteomicsPublicationsRNAReportingReproducibilityRetrievalSamplingScientistSignal TransductionSiteSourceSpecific qualifier valueStandardizationSubgroupSystemSystems BiologyTechniquesTherapeuticTherapeutic InterventionTissuesTranscriptTranslational ResearchValidationantigen bindingcancer biomarkerscancer subtypescancer typecloud basedcohortcomputerized data processingdata repositorydifferential expressionflexibilitygenomic dataimprovedindividual patientinsightinterestlaboratory experimentmetabolomicsmultiple omicsneoantigensnew therapeutic targetnext generation sequencingnovelpersonalized medicinephenotypic dataproteogenomicsresponsetherapeutic targettooltranscriptomicstranslational pipelinetumorubiquitin isopeptidase
项目摘要
Project Summary
Proteogenomics involves the integrative multi-omic analysis of genomic, transcriptomic, proteomic and post-
translational modification data produced by next-generation sequencing and mass spectrometry-based
proteomics. Several publications by the Clinical Proteomic Tumor Analysis Consortium (CPTAC) and others
have highlighted the impact of proteogenomics in enabling deeper insight into the biology of cancer and
identification of potential drug targets. Integrative analysis of multi-omic data requires the deployment of
complex algorithms and data processing techniques, which are generally inaccessible to scientists without a
background in bioinformatics and computational biology.
Our proposed center for comprehensive proteogenomic data analysis will encapsulate a comprehensive
set of analysis methods in a platform that will be (i) simple to use (ii) flexible (iii) automated, facilitating the
routine application to all CPTAC proteogenomic datasets as they become available, and (iv) able to
incorporate new methods with minimal effort. We will leverage PANOPLY--a cloud-based platform for
automated and reproducible proteogenomic data analysis--as the foundation, with specific, carefully chosen
algorithms targeted for addition to provide an expansive set of analysis capabilities that can be easily
harnessed to provide a rapid and extensive baseline analysis for proteogenomic studies, leading to many
disease specific hypotheses that can be explored further using additional computational and wet-lab
experiments.
Our collection of tools, algorithms and interactive reports will enable unprecedented, automated and integrative
systems-biology level analyses of proteome, post-translational modification and metabolomic data combined
with genomic data for individual disease cohorts and pan-cancer analysis across cohorts, leading to deeper
understanding of cancer biology and enabling identification of therapeutic targets and disease/prognostic
biomarkers.
项目总结
项目成果
期刊论文数量(0)
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{{ truncateString('GAD A GETZ', 18)}}的其他基金
Center for comprehensive proteogenomic data analysis
综合蛋白质组数据分析中心
- 批准号:
10440579 - 财政年份:2022
- 资助金额:
$ 77.53万 - 项目类别:
Comprehensive analysis of point mutations in cancer
癌症点突变综合分析
- 批准号:
10301857 - 财政年份:2021
- 资助金额:
$ 77.53万 - 项目类别:
Comprehensive analysis of point mutations in cancer
癌症点突变综合分析
- 批准号:
10491092 - 财政年份:2021
- 资助金额:
$ 77.53万 - 项目类别:
Comprehensive analysis of point mutations in cancer
癌症点突变综合分析
- 批准号:
10676830 - 财政年份:2021
- 资助金额:
$ 77.53万 - 项目类别:
Global Infrastructure for Collaborative High-throughput Cancer Genomics Analysis
协作高通量癌症基因组分析的全球基础设施
- 批准号:
9571405 - 财政年份:2016
- 资助金额:
$ 77.53万 - 项目类别:
Global Infrastructure for Collaborative High-throughput Cancer Genomics Analysis
协作高通量癌症基因组分析的全球基础设施
- 批准号:
9355157 - 财政年份:2016
- 资助金额:
$ 77.53万 - 项目类别:
Global Infrastructure for Collaborative High-throughput Cancer Genomics Analysis
协作高通量癌症基因组分析的全球基础设施
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10011769 - 财政年份:2016
- 资助金额:
$ 77.53万 - 项目类别:
Discovery of clinically distinct CLL subgroups by integrative mapping of large-scale CLL genetic, expression and clinical data
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- 批准号:
10005157 - 财政年份:2016
- 资助金额:
$ 77.53万 - 项目类别:
Global Infrastructure for Collaborative High-throughput Cancer Genomics Analysis
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- 批准号:
9211085 - 财政年份:2016
- 资助金额:
$ 77.53万 - 项目类别:
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