Comprehensive analysis of point mutations in cancer
癌症点突变综合分析
基本信息
- 批准号:10491092
- 负责人:
- 金额:$ 39.5万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-09-20 至 2026-08-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAftercareBiologicalBiopsyBloodCancer BiologyCancer PatientCancerousCellsClinicalClinical DataCodeCompetenceComplexComputational BiologyDNADNA MethylationDNA Sequence AlterationDataData AnalysesData SetDiagnosisDiseaseEpigenetic ProcessEventEvolutionFutureGenesGeneticGenomeGenome Data Analysis CenterGenome Data Analysis NetworkGenomic Data CommonsGenomicsGoalsHeterogeneityIndividualInternationalJournalsKnowledgeMachine LearningMalignant Childhood NeoplasmMalignant NeoplasmsMessenger RNAMethodsMethylationMicrosatellite RepeatsMolecular AbnormalityMutationMutation AnalysisNormal CellNucleotidesOncogenesOutcomePaperPathway interactionsPatientsPatternPlayPoint MutationProcessProductionPrognosisPublishingQuality ControlRNARegulatory ElementRepetitive SequenceResearchResistanceRoleSample SizeSamplingTechniquesThe Cancer Genome AtlasTherapeuticTissuesUntranslated RNAVariantWorkbasecancer genomecancer genomicscancer subtypescancer typecell free DNAcohortdriver mutationepigenomeflexibilitygenome analysisgenome sequencingimprovedinnovationinsertion/deletion mutationinterestneoantigensnext generationnovelpersonalized medicineprecision medicinepredictive modelingpromoterrare cancerresistance mechanismsingle-cell RNA sequencingsubclonal heterogeneitytargeted treatmenttherapeutic targettherapeutically effectivetooltranslational oncologytranslational scientisttumorwhole genomeworking group
项目摘要
PROJECT SUMMARY
Precision medicine in cancer, a disease of the genome, relies on a deep and comprehensive understanding of
the genetic mutations and abnormalities that accumulate in normal cells and drive transformation to cancer. The
Getz and Rheinbay Labs have expertise in the discovery and characterization of point mutations through rigorous
cancer genome analysis. In this proposal, we aim to create a Genome Data Analysis Center (GDAC) focused
on employing our existing tools to robustly and comprehensively characterize point mutations (single-nucleotide
variations and small indels) across the entire cancer genome to address scientific questions related to biological
underpinnings of cancer that arise in each project we are assigned. We also have the flexibility to adapt our tools
as deemed necessary by the unique needs of each project. Specifically, we plan to integrate and characterize
mutations, mutational signatures, and other data types to comprehensively discover cancer drivers in coding and
non-coding regions of the genome, including the often ignored more difficult-to-analyze regions of the genome.
We will do this by incorporating methods to determine DNA methylation signatures as well as by interrogating
the epigenome in both coding and non-coding regions of the genome. We further plan to advance our ability to
determine trajectories of tumor evolution and heterogeneity by adapting our PhylogicNDT suite of tools to
analyze the evolution, subclonal heterogeneity, and timing and order of mutational events from multiple samples
(e.g., samples acquired longitudinally or spatially) from the same patient, or even from cell-free DNA (cfDNA)
from non-invasive blood biopsy. In the interest of advancing the GDC’s goal of improving personalized medicine,
we teamed with expert clinicians and translational scientists, Dr. Keith Flaherty and Dr. Kirsten Kübler, that will
interpret our findings, associate them with clinical data and direct them towards clinical impact. They will also
enhance our tools for identifying the tissue- and cell-of-origin of cancers to not only better understand the
underlying mechanisms of transformation in a particular cancer type or subtype but also provide more effective
therapeutic targets. Moreover, our final Aim is to perform patient-specific analysis to improve and enable
precision medicine, especially in patients whose tumors do not have any identified actionable driver events.
Here, we will employ machine learning techniques to build predictive models of therapeutic vulnerabilities.
Overall, we offer primary competencies in DNA point mutation characterization, analysis of cfDNA, and
determination of mutational signatures to the GDAN. We also bring added value with secondary competencies
in methylation analysis (in the context of mutational signatures), mRNA analysis, single-cell RNA sequencing,
and pathway/integrative data analysis. Bringing our extensive expertise to the various newly assembled Analysis
Working Groups and collaborating with other GDACs within the GDAN can help to answer outstanding questions
in cancer with the ultimate goal of improving diagnosis, prognosis, and treatment for every cancer patient.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('GAD A GETZ', 18)}}的其他基金
Center for comprehensive proteogenomic data analysis
综合蛋白质组数据分析中心
- 批准号:
10440579 - 财政年份:2022
- 资助金额:
$ 39.5万 - 项目类别:
Center for comprehensive proteogenomic data analysis
综合蛋白质组数据分析中心
- 批准号:
10644013 - 财政年份:2022
- 资助金额:
$ 39.5万 - 项目类别:
Comprehensive analysis of point mutations in cancer
癌症点突变综合分析
- 批准号:
10301857 - 财政年份:2021
- 资助金额:
$ 39.5万 - 项目类别:
Comprehensive analysis of point mutations in cancer
癌症点突变综合分析
- 批准号:
10676830 - 财政年份:2021
- 资助金额:
$ 39.5万 - 项目类别:
Global Infrastructure for Collaborative High-throughput Cancer Genomics Analysis
协作高通量癌症基因组分析的全球基础设施
- 批准号:
9571405 - 财政年份:2016
- 资助金额:
$ 39.5万 - 项目类别:
Global Infrastructure for Collaborative High-throughput Cancer Genomics Analysis
协作高通量癌症基因组分析的全球基础设施
- 批准号:
9355157 - 财政年份:2016
- 资助金额:
$ 39.5万 - 项目类别:
Global Infrastructure for Collaborative High-throughput Cancer Genomics Analysis
协作高通量癌症基因组分析的全球基础设施
- 批准号:
10011769 - 财政年份:2016
- 资助金额:
$ 39.5万 - 项目类别:
Discovery of clinically distinct CLL subgroups by integrative mapping of large-scale CLL genetic, expression and clinical data
通过大规模 CLL 遗传、表达和临床数据的综合绘图发现临床上不同的 CLL 亚组
- 批准号:
10005157 - 财政年份:2016
- 资助金额:
$ 39.5万 - 项目类别:
Global Infrastructure for Collaborative High-throughput Cancer Genomics Analysis
协作高通量癌症基因组分析的全球基础设施
- 批准号:
9211085 - 财政年份:2016
- 资助金额:
$ 39.5万 - 项目类别:
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