Administrative Core for the Dietary Biomarkers Development Center at Harvard University
哈佛大学膳食生物标志物开发中心的行政核心
基本信息
- 批准号:10289794
- 负责人:
- 金额:$ 29.02万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-08-16 至 2026-06-30
- 项目状态:未结题
- 来源:
- 关键词:AchievementAmerican dietAreaBioinformaticsBiological AssayBiological MarkersBiotechnologyBudgetsCarbohydratesCollectionCommittee MembersCommunicationCommunitiesDataData AnalysesData Coordinating CenterDatabasesDietDietary AssessmentDietary InterventionDietary intakeEatingEnergy IntakeEnsureEnvironmentEvaluationExpenditureFollow-Up StudiesFoodGoalsHealth ProfessionalHourIndividualInfrastructureInstitutionInstitutional Review BoardsIntakeInterdisciplinary StudyInterventionIntervention TrialLeadLeadershipMeasurementMeasuresMedicalNational Institute of Diabetes and Digestive and Kidney DiseasesNitrogenNurses&apos Health StudyNutrientNutritional BiochemistryNutritional StudyObesityObservational StudyPatient RecruitmentsPatient Self-ReportPlayPopulation SciencesPostdoctoral FellowPotassiumProgress ReportsProspective cohort studyProteinsPublic Health SchoolsQuality ControlRandomized Clinical TrialsRecoveryResearchResearch DesignResearch PersonnelResourcesRoleScheduleScienceSourceTechniquesTimeTravelUnited States National Institutes of HealthUniversitiesUpdateWorkbioinformatics toolbiomarker developmentcatalystdata sharingdata submissiondietarydoubly-labeled waterfeedinggraduate studenthuman subjectimprovedinnovationmeetingsmetabolomicsmultidisciplinarynovelnovel markernutritionprogramsprotein intaketechnology developmenttraining opportunityurinaryweb site
项目摘要
PROJECT ABSTRACT/SUMMARY – ADMINISTRATIVE CORE
Traditionally, nutrition research has relied heavily on self-reported measures of dietary intake that are often
prone to measurement error. To date, only a few recovery biomarkers of nutrient intake have been established,
including doubly labeled water for estimating energy intake, 24-hour urinary nitrogen for estimating protein
intake, and 24-hour urinary potassium as a biomarker of potassium intake. This highlights the urgent need to
identify further objective and robust biomarkers of food intakes. Recent advances in high-throughput -omics
technologies and the development of novel bioinformatic tools now enable the unbiased discovery of novel
biomarkers that are sensitive and specific to intakes of foods and food groups. The overall objective of the
Dietary Biomarker Development Center (DBDC) at Harvard University is to identify and validate dietary
biomarkers of important protein and carbohydrate food sources in the US diet by using the state-of-the-art
metabolomic techniques and through a combination of well-controlled dietary intervention trials and
observational studies. Our objective is to establish an Administrative Core will play scientific and
administrative leadership roles by integrating the Intervention Core, Data Analysis Core, Metabolomics Core,
and the Biomarkers Project to improve efficiency, enhance innovation, and extend the breadth and depth of the
science within the DBDC at Harvard and across the DBDC’s and the Data Coordinating Center (DCC). The
Core will be led by Dr. Frank Hu, with co-leadership provided by Dr. Clary Clish. Additional key leadership will
be provided by Executive Committee (EC) members, including the Core PIs and Directors and the Project
Director, Dr. Shilpa Bhupathiraju. The DBDC at Harvard Center brings together investigators of diverse
backgrounds and expertise to identify novel biomarkers of several important carbohydrate and protein sources
in the US diet. The expertise in our research team is wide-ranging, covering dietary assessment, population
science, nutritional biochemistry, bioinformatics, and biotechnologies. The stimulating intellectual environment
in the Longwood/Harvard Medical Area is highly conducive for carrying out this research. The Center will take
full advantage of institutional commitment and resources provided by HSPH and other participating institutions,
as well as those provided by the broader Harvard community, such as Harvard Catalyst and the Harvard
Nutrition and Obesity Research Center. The infrastructure for the Administrative Core will provide a strong and
visionary leadership role in science, administration, and dissemination for the DBDC at Harvard University.
项目摘要/摘要-行政核心
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Frank B Hu其他文献
Popular weight-loss diets: from evidence to practice
流行的减肥饮食:从证据到实践
- DOI:
10.1038/ncpcardio0726 - 发表时间:
2007-01-01 - 期刊:
- 影响因子:44.200
- 作者:
Vasanti S Malik;Frank B Hu - 通讯作者:
Frank B Hu
Three decades of the Mediterranean diet pyramid: A narrative review of its history, evolution, and advances
- DOI:
10.1016/j.ajcnut.2025.04.036 - 发表时间:
2025-07-01 - 期刊:
- 影响因子:6.900
- 作者:
Frank B Hu;Greg Drescher;Antonia Trichopoulou;Walter C Willett;Miguel A Martínez-González - 通讯作者:
Miguel A Martínez-González
Food additive emulsifiers: a new risk factor for type 2 diabetes?
食品添加剂乳化剂:2型糖尿病的新危险因素?
- DOI:
- 发表时间:
2024 - 期刊:
- 影响因子:0
- 作者:
Mengxi Du;Frank B Hu - 通讯作者:
Frank B Hu
Title page, program participants, and TOC
- DOI:
10.3945/ajcn/100.6.1607s - 发表时间:
2014-12-01 - 期刊:
- 影响因子:
- 作者:
An Pan;Frank B Hu - 通讯作者:
Frank B Hu
Dietary patterns, serum metabolites, and risk of cardiovascular disease in United States Hispanic/Latino adults: a prospective analysis of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
- DOI:
10.1016/j.ajcnut.2025.05.008 - 发表时间:
2025-07-01 - 期刊:
- 影响因子:6.900
- 作者:
Hongbo Yang;Yi Wang;Kai Luo;Yasmin Mossavar-Rahmani;Christina Cordero;Robert J Ostfeld;Claudia Martinez;Luis Maldonado;Amber Pirzada;Martha Daviglus;Bing Yu;Frank B Hu;Robert C Kaplan;Qibin Qi - 通讯作者:
Qibin Qi
Frank B Hu的其他文献
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{{ truncateString('Frank B Hu', 18)}}的其他基金
Lifestyle Interventions, metabolites, microbiome, and diabetes risk
生活方式干预、代谢物、微生物组和糖尿病风险
- 批准号:
10557795 - 财政年份:2021
- 资助金额:
$ 29.02万 - 项目类别:
Administrative Core for the Dietary Biomarkers Development Center at Harvard University
哈佛大学膳食生物标志物开发中心的行政核心
- 批准号:
10461132 - 财政年份:2021
- 资助金额:
$ 29.02万 - 项目类别:
Administrative Core for the Dietary Biomarkers Development Center at Harvard University
哈佛大学膳食生物标志物开发中心的行政核心
- 批准号:
10649586 - 财政年份:2021
- 资助金额:
$ 29.02万 - 项目类别:
Lifestyle Interventions, metabolites, microbiome, and diabetes risk
生活方式干预、代谢物、微生物组和糖尿病风险
- 批准号:
10370323 - 财政年份:2021
- 资助金额:
$ 29.02万 - 项目类别:
Dietary Interventions, Metabolites, and Risk of Type 2 Diabetes
饮食干预、代谢物和 2 型糖尿病的风险
- 批准号:
8918612 - 财政年份:2014
- 资助金额:
$ 29.02万 - 项目类别:
Dietary Interventions, Metabolites, and Risk of Type 2 Diabetes
饮食干预、代谢物和 2 型糖尿病的风险
- 批准号:
8760615 - 财政年份:2014
- 资助金额:
$ 29.02万 - 项目类别:
Mediterranean diet, Metabolites, and cardiovascular Disease
地中海饮食、代谢物和心血管疾病
- 批准号:
9090169 - 财政年份:2013
- 资助金额:
$ 29.02万 - 项目类别:
Mediterranean diet, Metabolites, and Cardiovascular Disease
地中海饮食、代谢物和心血管疾病
- 批准号:
10551729 - 财政年份:2013
- 资助金额:
$ 29.02万 - 项目类别:
Mediterranean diet, Metabolites, and cardiovascular Disease
地中海饮食、代谢物和心血管疾病
- 批准号:
8482202 - 财政年份:2013
- 资助金额:
$ 29.02万 - 项目类别:
Mediterranean diet, Metabolites, and cardiovascular Disease
地中海饮食、代谢物和心血管疾病
- 批准号:
9388404 - 财政年份:2013
- 资助金额:
$ 29.02万 - 项目类别:
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