Lifestyle Interventions, metabolites, microbiome, and diabetes risk
生活方式干预、代谢物、微生物组和糖尿病风险
基本信息
- 批准号:10370323
- 负责人:
- 金额:$ 48.27万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-03-15 至 2025-01-31
- 项目状态:未结题
- 来源:
- 关键词:AccelerometerAdipose tissueAncillary StudyAttenuatedBehavioralBioinformaticsBody CompositionBody WeightBody Weight decreasedCardiovascular systemChronic DiseaseConsumptionControl GroupsDevelopmentDiabetes preventionDietDietary InterventionDual-Energy X-Ray AbsorptiometryFatty acid glycerol estersFecesFunctional disorderGlycosylated hemoglobin AGrantIncidenceIndividualInterventionLife StyleMeasuresMediatingMediterranean DietMetabolic PathwayNested Case-Control StudyNon-Insulin-Dependent Diabetes MellitusOlive oil preparationParticipantPhysical FitnessPhysical activityPlacebosPlasmaPopulationPreventionPrevention trialRandomized Clinical TrialsRecommendationRiskStatistical MethodsTestingVisceralWomanageddiabetes prevention programdiabetes riskdietarydisorder preventionfitnessfollow-upgroup interventiongut microbiomehealthy lifestyleintervention effectlifestyle interventionmenmetabolic profilemicrobiomemulti-ethnicnon-diabeticprecision nutritionprospectiverecruitsecondary endpointstool sampletyrosolurinary
项目摘要
Abstract
This application is an ancillary study of the PREDIMED-Plus trial to examine the effects of a diet and lifestyle
intervention on incidence of T2D as a secondary endpoint among 4,770 participants who were non-diabetics
at baseline. PREDIMED-Plus is an ongoing primary cardiovascular prevention trial (www.predimedplus.com),
which has recruited 6,874 women and men (aged 55 to 75 years) between October 2013 and December
2016. Participants were randomly allocated to 2 groups: an energy-reduced Mediterranean diet (MedDiet)
group, with physical activity and behavioral support for weight loss; or a control group receiving low-intensity
advice on the MedDiet. The intervention will last 6 years. We will examine four Specific Aims. First, we will
evaluate whether an intensive lifestyle intervention consisting of an energy-reduced MedDiet, increased
physical activity, and weight loss, reduces the incidence of T2D comparied with the control group
(intervention group n=2,384; control group n=2,451). Second, we will evaluate the effect of the lifestyle
intervention on total fat mass and visceral adipose tissue (VAT) measured by Dual-energy X-ray
Absorptiometry (DXA) after 1, 3, and 6-year intervention in a subsample (n=1,569). Third, we will examine
whether the lifestyle intervention modifies the association of the metabolite risk score (MRS) with the
incidence of T2D in a nested case-control study (n=620 incident T2D cases and 620 matched controls).
These analyses will be replicated in the multi-ethnic US Diabetes Prevention Program (DPP, 775 cases and
1,386 non-cases from the placebo/lifestyle groups). Fourth, we will examine whether the intervention induces
beneficial changes in stool metabolites from baseline to year 1, in a subsample of 250 participants in the
intervention group and 250 in the control group. We will also examine whether changes in stool metabolites
are associated with changes in gut microbiome induced by the intervention. The preliminary results among
the PREDIMED-Plus participants showed that the intervention significantly reduced body weight and HbA1c,
which was sustained over three years. This study builds upon a large RCT and will be the first and largest of
its kind to prospectively assess the effects of an intensive lifestyle intervention on plasma and stool
metabolites and the risk of T2D, using the state-of-the-art LC-MS platform and cutting-edge bioinformatics
and statistical methods. Objective measures will be used to assess functional fitness (a 30-second chair sit-
and-stand (CSS) test), physical activity (accelerometers), body composition (DXA), and extra-virgin olive oil
consumption (urinary tyrosol and hydroxytyrosol levels). This application has the potential to advance our
understanding of T2D pathophysiology and inform precision nutrition and T2D prevention. It has important
implications for the US population because it may provide further evidence to strengthen current
recommendations on the MedDiet as a part of a healthy lifestyle for chronic disease prevention.
摘要
本申请是PREDIMED-Plus试验的辅助研究,旨在检查饮食和生活方式的影响
在4,770名非糖尿病受试者中对T2 D发生率进行干预作为次要终点
在基线。PREDIMED-Plus是一项正在进行的一级心血管预防试验(www.predimedplus.com),
该组织在2013年10月至2014年12月期间招募了6,874名女性和男性(年龄在55至75岁之间)
2016.参与者被随机分配到2组:能量减少的地中海饮食(MedDiet)
一组,通过身体活动和行为支持减肥;或对照组接受低强度
关于MedDiet的建议干预将持续6年。我们将研究四个具体目标。一是
评估是否强化生活方式干预,包括能量减少的MedDiet,增加
与对照组相比,体力活动和体重减轻降低了T2 D的发病率
(干预组n= 2,384;对照组n= 2,451)。其次,我们将评估生活方式的影响
双能X线测量总脂肪量和内脏脂肪组织干预研究
在子样本(n= 1,569)中进行1年、3年和6年干预后的吸光度测定(DXA)。第三,我们将研究
生活方式干预是否改变代谢物风险评分(MRS)与
一项巢式病例对照研究中T2 D的发病率(n=620例T2 D发病病例和620例匹配对照)。
这些分析将在多种族的美国糖尿病预防项目(DPP,775例,
安慰剂/生活方式组的1,386例非病例)。第四,我们将研究干预是否会导致
在250名参与者的子样本中,从基线到第1年粪便代谢物的有益变化,
对照组250例。我们还将检查粪便代谢物的变化
与干预引起的肠道微生物组变化有关。初步结果显示,
PREDIMED-Plus参与者显示干预显著降低了体重和HbA 1c,
持续了三年多这项研究建立在一个大型RCT的基础上,将是第一个也是最大的
前瞻性评估强化生活方式干预对血浆和粪便的影响
代谢物和T2 D风险,使用最先进的LC-MS平台和尖端的生物信息学
和统计方法。客观的措施将被用来评估功能健康(30秒的椅子坐,
站立(CSS)测试),身体活动(加速计),身体成分(DXA)和特级初榨橄榄油
消耗(尿酪醇和羟基酪醇水平)。这个应用程序有可能推动我们的
了解T2 D病理生理学,并为精确营养和T2 D预防提供信息。具有重要
对美国人口的影响,因为它可能提供进一步的证据,以加强目前的
建议将MedDiet作为预防慢性病的健康生活方式的一部分。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Frank B Hu其他文献
Popular weight-loss diets: from evidence to practice
流行的减肥饮食:从证据到实践
- DOI:
10.1038/ncpcardio0726 - 发表时间:
2007-01-01 - 期刊:
- 影响因子:44.200
- 作者:
Vasanti S Malik;Frank B Hu - 通讯作者:
Frank B Hu
Three decades of the Mediterranean diet pyramid: A narrative review of its history, evolution, and advances
- DOI:
10.1016/j.ajcnut.2025.04.036 - 发表时间:
2025-07-01 - 期刊:
- 影响因子:6.900
- 作者:
Frank B Hu;Greg Drescher;Antonia Trichopoulou;Walter C Willett;Miguel A Martínez-González - 通讯作者:
Miguel A Martínez-González
Food additive emulsifiers: a new risk factor for type 2 diabetes?
食品添加剂乳化剂:2型糖尿病的新危险因素?
- DOI:
- 发表时间:
2024 - 期刊:
- 影响因子:0
- 作者:
Mengxi Du;Frank B Hu - 通讯作者:
Frank B Hu
Title page, program participants, and TOC
- DOI:
10.3945/ajcn/100.6.1607s - 发表时间:
2014-12-01 - 期刊:
- 影响因子:
- 作者:
An Pan;Frank B Hu - 通讯作者:
Frank B Hu
Dietary patterns, serum metabolites, and risk of cardiovascular disease in United States Hispanic/Latino adults: a prospective analysis of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
- DOI:
10.1016/j.ajcnut.2025.05.008 - 发表时间:
2025-07-01 - 期刊:
- 影响因子:6.900
- 作者:
Hongbo Yang;Yi Wang;Kai Luo;Yasmin Mossavar-Rahmani;Christina Cordero;Robert J Ostfeld;Claudia Martinez;Luis Maldonado;Amber Pirzada;Martha Daviglus;Bing Yu;Frank B Hu;Robert C Kaplan;Qibin Qi - 通讯作者:
Qibin Qi
Frank B Hu的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Frank B Hu', 18)}}的其他基金
Lifestyle Interventions, metabolites, microbiome, and diabetes risk
生活方式干预、代谢物、微生物组和糖尿病风险
- 批准号:
10557795 - 财政年份:2021
- 资助金额:
$ 48.27万 - 项目类别:
Administrative Core for the Dietary Biomarkers Development Center at Harvard University
哈佛大学膳食生物标志物开发中心的行政核心
- 批准号:
10461132 - 财政年份:2021
- 资助金额:
$ 48.27万 - 项目类别:
Administrative Core for the Dietary Biomarkers Development Center at Harvard University
哈佛大学膳食生物标志物开发中心的行政核心
- 批准号:
10649586 - 财政年份:2021
- 资助金额:
$ 48.27万 - 项目类别:
Administrative Core for the Dietary Biomarkers Development Center at Harvard University
哈佛大学膳食生物标志物开发中心的行政核心
- 批准号:
10289794 - 财政年份:2021
- 资助金额:
$ 48.27万 - 项目类别:
Dietary Interventions, Metabolites, and Risk of Type 2 Diabetes
饮食干预、代谢物和 2 型糖尿病的风险
- 批准号:
8918612 - 财政年份:2014
- 资助金额:
$ 48.27万 - 项目类别:
Dietary Interventions, Metabolites, and Risk of Type 2 Diabetes
饮食干预、代谢物和 2 型糖尿病的风险
- 批准号:
8760615 - 财政年份:2014
- 资助金额:
$ 48.27万 - 项目类别:
Mediterranean diet, Metabolites, and cardiovascular Disease
地中海饮食、代谢物和心血管疾病
- 批准号:
9090169 - 财政年份:2013
- 资助金额:
$ 48.27万 - 项目类别:
Mediterranean diet, Metabolites, and Cardiovascular Disease
地中海饮食、代谢物和心血管疾病
- 批准号:
10551729 - 财政年份:2013
- 资助金额:
$ 48.27万 - 项目类别:
Mediterranean diet, Metabolites, and cardiovascular Disease
地中海饮食、代谢物和心血管疾病
- 批准号:
8482202 - 财政年份:2013
- 资助金额:
$ 48.27万 - 项目类别:
Mediterranean diet, Metabolites, and cardiovascular Disease
地中海饮食、代谢物和心血管疾病
- 批准号:
9388404 - 财政年份:2013
- 资助金额:
$ 48.27万 - 项目类别:
相似海外基金
Deciphering the role of adipose tissue in common metabolic disease via adipose tissue proteomics
通过脂肪组织蛋白质组学解读脂肪组织在常见代谢疾病中的作用
- 批准号:
MR/Y013891/1 - 财政年份:2024
- 资助金额:
$ 48.27万 - 项目类别:
Research Grant
ESTABLISHING THE ROLE OF ADIPOSE TISSUE INFLAMMATION IN THE REGULATION OF MUSCLE MASS IN OLDER PEOPLE
确定脂肪组织炎症在老年人肌肉质量调节中的作用
- 批准号:
BB/Y006542/1 - 财政年份:2024
- 资助金额:
$ 48.27万 - 项目类别:
Research Grant
Canadian Alliance of Healthy Hearts and Minds: Dissecting the Pathways Linking Ectopic Adipose Tissue to Cognitive Dysfunction
加拿大健康心灵联盟:剖析异位脂肪组织与认知功能障碍之间的联系途径
- 批准号:
479570 - 财政年份:2023
- 资助金额:
$ 48.27万 - 项目类别:
Operating Grants
Determinants of Longitudinal Progression of Adipose Tissue Inflammation in Individuals at High-Risk for Type 2 Diabetes: Novel Insights from Metabolomic Profiling
2 型糖尿病高危个体脂肪组织炎症纵向进展的决定因素:代谢组学分析的新见解
- 批准号:
488898 - 财政年份:2023
- 资助金额:
$ 48.27万 - 项目类别:
Operating Grants
Activation of human brown adipose tissue using food ingredients that enhance the bioavailability of nitric oxide
使用增强一氧化氮生物利用度的食品成分激活人体棕色脂肪组织
- 批准号:
23H03323 - 财政年份:2023
- 资助金额:
$ 48.27万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Development of new lung regeneration therapies by elucidating the lung regeneration mechanism of adipose tissue-derived stem cells
通过阐明脂肪组织干细胞的肺再生机制开发新的肺再生疗法
- 批准号:
23K08293 - 财政年份:2023
- 资助金额:
$ 48.27万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
A study on the role of brown adipose tissue in the development and maintenance of skeletal muscles
棕色脂肪组织在骨骼肌发育和维持中作用的研究
- 批准号:
23K19922 - 财政年份:2023
- 资助金额:
$ 48.27万 - 项目类别:
Grant-in-Aid for Research Activity Start-up
Adipose Tissue T Cell Polarization and Metabolic Health in Persons Living with HIV
HIV 感染者的脂肪组织 T 细胞极化和代谢健康
- 批准号:
10619176 - 财政年份:2023
- 资助金额:
$ 48.27万 - 项目类别:
Estrogen Signaling in the Ventromedial Hypothalamus Modulates Adipose Tissue Metabolic Adaptation
下丘脑腹内侧区的雌激素信号调节脂肪组织代谢适应
- 批准号:
10604611 - 财政年份:2023
- 资助金额:
$ 48.27万 - 项目类别:
Obesity and Childhood Asthma: The Role of Adipose Tissue
肥胖和儿童哮喘:脂肪组织的作用
- 批准号:
10813753 - 财政年份:2023
- 资助金额:
$ 48.27万 - 项目类别: