Dietary Interventions, Metabolites, and Risk of Type 2 Diabetes

饮食干预、代谢物和 2 型糖尿病的风险

基本信息

  • 批准号:
    8918612
  • 负责人:
  • 金额:
    $ 48.19万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2014
  • 资助国家:
    美国
  • 起止时间:
    2014-09-01 至 2018-08-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Type 2 diabetes (T2D) has reached epidemic proportion. Lifestyle factors such as a healthy diet are crucial for T2D prevention. Recently, the PREDIMED (PREvencion con DIeta MEDiterranea) trial was completed in Spain. The trial was a multicenter, randomized controlled trial in which 7,447 participants were randomly allocated to Mediterranean dietary interventions enriched with extra virgin olive oil or nuts or a control diet. Although the trial was primarily designed to assess the effect of the interventions on CVD, the dietary interventions also reduced incidence of T2D by 30% (95% CI 0.54-0.92). The goal of the present study is to examine whether the effects of Mediterranean diet on changes in metabolites and T2D risk. We will employ a case-cohort study design with 273 incident cases of T2D and 708 randomly selected participants free of diabetes at baseline (20%). Stored fasting blood specimens collected at baseline and at year 1 of the trial will be measured for a well-validated panel of ~300 metabolites, using the state-of-the-art LC-MS technology. Our Specific Aims are: 1) To examine the association between the baseline metabolite concentrations and the risk of T2D using a case-cohort design; 2). To examine whether the dietary interventions modify the relationships between baseline levels of metabolites and subsequent T2D risk using a case- cohort design; 3). To examine whether 1-year changes in metabolites mediate the effect of the dietary interventions on subsequent T2D outcomes from years 2 to 5 using a case-cohort design; and 4). To examine whether 1-year changes in metabolites influence insulin resistance and �-cell function from years 2 to 5 among 708 randomly selected participants free of diabetes at baseline. The large PREDIMED trial, with archived plasma samples and rich repeated measurements of diet, lifestyle, and biomarkers, represents an unprecedented opportunity to address our specific aims in an extremely cost-effective manner. This project has great potential to advance our understanding of the metabolic pathways through which dietary interventions influence T2D risk. It also has important public health and clinical implications because many of these metabolites and their associated pathways may be suitable for direct diet and lifestyle interventions. To prepare for this project, we have already completed a preliminary study by randomly selecting 20 samples from each diet group at one year of intervention and conducted metabolomic analyses using LC-MS at the Broad Institute of MIT and Harvard.
描述(申请人提供):2型糖尿病(T2 D)已达到流行比例。健康饮食等生活方式因素对预防T2 D至关重要。最近,西班牙完成了PREDIMED(PREvencion con DIeta MEDIPEEA)试验。该试验是一项多中心随机对照试验,其中7,447名参与者被随机分配到富含特级初榨橄榄油或坚果的地中海饮食干预或对照饮食。 尽管该试验主要旨在评估干预措施对CVD的影响,但饮食干预也使T2 D的发病率降低了30%(95%CI 0.54-0.92)。本研究的目的是检查地中海饮食对代谢物变化和T2 D风险的影响。我们将采用病例队列研究设计,纳入273例T2 D事件病例和708例随机选择的基线无糖尿病的参与者(20%)。将使用最先进的LC-MS技术,测量基线和试验第1年采集的储存空腹血液标本中经过充分验证的约300种代谢产物。我们的具体目标是:1)使用病例队列设计检查基线代谢物浓度与T2 D风险之间的关联; 2)。使用病例队列设计来检查饮食干预是否改变代谢物基线水平与随后的T2 D风险之间的关系; 3)。使用病例队列设计,检查代谢物的1年变化是否介导饮食干预对2 - 5年后续T2 D结局的影响;和4)。在708名随机选择的基线时无糖尿病的参与者中,研究代谢物的1年变化是否影响2 - 5年的胰岛素抵抗和β细胞功能。大型PREDIMED试验,存档的血浆样本和丰富的饮食,生活方式和生物标志物的重复测量,代表了一个前所未有的机会,以极其具有成本效益的方式解决我们的特定目标。该项目有很大的潜力,以促进我们的代谢途径的理解,通过饮食干预影响T2 D风险。它还具有重要的公共卫生和临床意义,因为这些代谢物及其相关途径中的许多可能适用于直接的饮食和生活方式干预。为了准备这个项目,我们已经完成了一项初步研究,在一年的干预中从每个饮食组中随机选择20个样本,并在麻省理工学院和哈佛的布罗德研究所使用LC-MS进行代谢组学分析。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Frank B Hu其他文献

Popular weight-loss diets: from evidence to practice
流行的减肥饮食:从证据到实践
  • DOI:
    10.1038/ncpcardio0726
  • 发表时间:
    2007-01-01
  • 期刊:
  • 影响因子:
    44.200
  • 作者:
    Vasanti S Malik;Frank B Hu
  • 通讯作者:
    Frank B Hu
Three decades of the Mediterranean diet pyramid: A narrative review of its history, evolution, and advances
  • DOI:
    10.1016/j.ajcnut.2025.04.036
  • 发表时间:
    2025-07-01
  • 期刊:
  • 影响因子:
    6.900
  • 作者:
    Frank B Hu;Greg Drescher;Antonia Trichopoulou;Walter C Willett;Miguel A Martínez-González
  • 通讯作者:
    Miguel A Martínez-González
Food additive emulsifiers: a new risk factor for type 2 diabetes?
食品添加剂乳化剂:2型糖尿病的新危险因素?
Title page, program participants, and TOC
  • DOI:
    10.3945/ajcn/100.6.1607s
  • 发表时间:
    2014-12-01
  • 期刊:
  • 影响因子:
  • 作者:
    An Pan;Frank B Hu
  • 通讯作者:
    Frank B Hu
Coffee Consumption, Additive Use, and Risk of Type 2 Diabetes—Results from 3 Large Prospective United States Cohort Studies
咖啡摄入量、添加剂使用与2型糖尿病风险——来自三项美国大型前瞻性队列研究的结果
  • DOI:
    10.1016/j.ajcnut.2025.01.017
  • 发表时间:
    2025-03-01
  • 期刊:
  • 影响因子:
    6.900
  • 作者:
    Matthias Henn;Andrea J Glenn;Walter C Willett;Miguel A Martínez-González;Qi Sun;Frank B Hu
  • 通讯作者:
    Frank B Hu

Frank B Hu的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Frank B Hu', 18)}}的其他基金

Lifestyle Interventions, metabolites, microbiome, and diabetes risk
生活方式干预、代谢物、微生物组和糖尿病风险
  • 批准号:
    10557795
  • 财政年份:
    2021
  • 资助金额:
    $ 48.19万
  • 项目类别:
Administrative Core for the Dietary Biomarkers Development Center at Harvard University
哈佛大学膳食生物标志物开发中心的行政核心
  • 批准号:
    10461132
  • 财政年份:
    2021
  • 资助金额:
    $ 48.19万
  • 项目类别:
Administrative Core for the Dietary Biomarkers Development Center at Harvard University
哈佛大学膳食生物标志物开发中心的行政核心
  • 批准号:
    10649586
  • 财政年份:
    2021
  • 资助金额:
    $ 48.19万
  • 项目类别:
Lifestyle Interventions, metabolites, microbiome, and diabetes risk
生活方式干预、代谢物、微生物组和糖尿病风险
  • 批准号:
    10370323
  • 财政年份:
    2021
  • 资助金额:
    $ 48.19万
  • 项目类别:
Administrative Core for the Dietary Biomarkers Development Center at Harvard University
哈佛大学膳食生物标志物开发中心的行政核心
  • 批准号:
    10289794
  • 财政年份:
    2021
  • 资助金额:
    $ 48.19万
  • 项目类别:
Dietary Interventions, Metabolites, and Risk of Type 2 Diabetes
饮食干预、代谢物和 2 型糖尿病的风险
  • 批准号:
    8760615
  • 财政年份:
    2014
  • 资助金额:
    $ 48.19万
  • 项目类别:
Mediterranean diet, Metabolites, and cardiovascular Disease
地中海饮食、代谢物和心血管疾病
  • 批准号:
    9090169
  • 财政年份:
    2013
  • 资助金额:
    $ 48.19万
  • 项目类别:
Mediterranean diet, Metabolites, and Cardiovascular Disease
地中海饮食、代谢物和心血管疾病
  • 批准号:
    10551729
  • 财政年份:
    2013
  • 资助金额:
    $ 48.19万
  • 项目类别:
Mediterranean diet, Metabolites, and cardiovascular Disease
地中海饮食、代谢物和心血管疾病
  • 批准号:
    8482202
  • 财政年份:
    2013
  • 资助金额:
    $ 48.19万
  • 项目类别:
Mediterranean diet, Metabolites, and cardiovascular Disease
地中海饮食、代谢物和心血管疾病
  • 批准号:
    9388404
  • 财政年份:
    2013
  • 资助金额:
    $ 48.19万
  • 项目类别:

相似海外基金

Co-designing a lifestyle, stop-vaping intervention for ex-smoking, adult vapers (CLOVER study)
为戒烟的成年电子烟使用者共同设计生活方式、戒烟干预措施(CLOVER 研究)
  • 批准号:
    MR/Z503605/1
  • 财政年份:
    2024
  • 资助金额:
    $ 48.19万
  • 项目类别:
    Research Grant
Early Life Antecedents Predicting Adult Daily Affective Reactivity to Stress
早期生活经历预测成人对压力的日常情感反应
  • 批准号:
    2336167
  • 财政年份:
    2024
  • 资助金额:
    $ 48.19万
  • 项目类别:
    Standard Grant
RAPID: Affective Mechanisms of Adjustment in Diverse Emerging Adult Student Communities Before, During, and Beyond the COVID-19 Pandemic
RAPID:COVID-19 大流行之前、期间和之后不同新兴成人学生社区的情感调整机制
  • 批准号:
    2402691
  • 财政年份:
    2024
  • 资助金额:
    $ 48.19万
  • 项目类别:
    Standard Grant
Elucidation of Adult Newt Cells Regulating the ZRS enhancer during Limb Regeneration
阐明成体蝾螈细胞在肢体再生过程中调节 ZRS 增强子
  • 批准号:
    24K12150
  • 财政年份:
    2024
  • 资助金额:
    $ 48.19万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Migrant Youth and the Sociolegal Construction of Child and Adult Categories
流动青年与儿童和成人类别的社会法律建构
  • 批准号:
    2341428
  • 财政年份:
    2024
  • 资助金额:
    $ 48.19万
  • 项目类别:
    Standard Grant
Understanding how platelets mediate new neuron formation in the adult brain
了解血小板如何介导成人大脑中新神经元的形成
  • 批准号:
    DE240100561
  • 财政年份:
    2024
  • 资助金额:
    $ 48.19万
  • 项目类别:
    Discovery Early Career Researcher Award
RUI: Evaluation of Neurotrophic-Like properties of Spaetzle-Toll Signaling in the Developing and Adult Cricket CNS
RUI:评估发育中和成年蟋蟀中枢神经系统中 Spaetzle-Toll 信号传导的神经营养样特性
  • 批准号:
    2230829
  • 财政年份:
    2023
  • 资助金额:
    $ 48.19万
  • 项目类别:
    Standard Grant
Usefulness of a question prompt sheet for onco-fertility in adolescent and young adult patients under 25 years old.
问题提示表对于 25 岁以下青少年和年轻成年患者的肿瘤生育力的有用性。
  • 批准号:
    23K09542
  • 财政年份:
    2023
  • 资助金额:
    $ 48.19万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Identification of new specific molecules associated with right ventricular dysfunction in adult patients with congenital heart disease
鉴定与成年先天性心脏病患者右心室功能障碍相关的新特异性分子
  • 批准号:
    23K07552
  • 财政年份:
    2023
  • 资助金额:
    $ 48.19万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Issue identifications and model developments in transitional care for patients with adult congenital heart disease.
成人先天性心脏病患者过渡护理的问题识别和模型开发。
  • 批准号:
    23K07559
  • 财政年份:
    2023
  • 资助金额:
    $ 48.19万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了