Dietary Interventions, Metabolites, and Risk of Type 2 Diabetes

饮食干预、代谢物和 2 型糖尿病的风险

基本信息

  • 批准号:
    8918612
  • 负责人:
  • 金额:
    $ 48.19万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2014
  • 资助国家:
    美国
  • 起止时间:
    2014-09-01 至 2018-08-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Type 2 diabetes (T2D) has reached epidemic proportion. Lifestyle factors such as a healthy diet are crucial for T2D prevention. Recently, the PREDIMED (PREvencion con DIeta MEDiterranea) trial was completed in Spain. The trial was a multicenter, randomized controlled trial in which 7,447 participants were randomly allocated to Mediterranean dietary interventions enriched with extra virgin olive oil or nuts or a control diet. Although the trial was primarily designed to assess the effect of the interventions on CVD, the dietary interventions also reduced incidence of T2D by 30% (95% CI 0.54-0.92). The goal of the present study is to examine whether the effects of Mediterranean diet on changes in metabolites and T2D risk. We will employ a case-cohort study design with 273 incident cases of T2D and 708 randomly selected participants free of diabetes at baseline (20%). Stored fasting blood specimens collected at baseline and at year 1 of the trial will be measured for a well-validated panel of ~300 metabolites, using the state-of-the-art LC-MS technology. Our Specific Aims are: 1) To examine the association between the baseline metabolite concentrations and the risk of T2D using a case-cohort design; 2). To examine whether the dietary interventions modify the relationships between baseline levels of metabolites and subsequent T2D risk using a case- cohort design; 3). To examine whether 1-year changes in metabolites mediate the effect of the dietary interventions on subsequent T2D outcomes from years 2 to 5 using a case-cohort design; and 4). To examine whether 1-year changes in metabolites influence insulin resistance and �-cell function from years 2 to 5 among 708 randomly selected participants free of diabetes at baseline. The large PREDIMED trial, with archived plasma samples and rich repeated measurements of diet, lifestyle, and biomarkers, represents an unprecedented opportunity to address our specific aims in an extremely cost-effective manner. This project has great potential to advance our understanding of the metabolic pathways through which dietary interventions influence T2D risk. It also has important public health and clinical implications because many of these metabolites and their associated pathways may be suitable for direct diet and lifestyle interventions. To prepare for this project, we have already completed a preliminary study by randomly selecting 20 samples from each diet group at one year of intervention and conducted metabolomic analyses using LC-MS at the Broad Institute of MIT and Harvard.
描述(申请人提供):2型糖尿病(T2D)已达到流行比例。健康饮食等生活方式因素对预防糖尿病至关重要。最近,PREDIMED (PREvencion con DIeta MEDiterranea)试验在西班牙完成。该试验是一项多中心、随机对照试验,7447名参与者被随机分配到富含特级初榨橄榄油或坚果的地中海饮食干预组或对照饮食组。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Frank B Hu其他文献

Popular weight-loss diets: from evidence to practice
流行的减肥饮食:从证据到实践
  • DOI:
    10.1038/ncpcardio0726
  • 发表时间:
    2007-01-01
  • 期刊:
  • 影响因子:
    44.200
  • 作者:
    Vasanti S Malik;Frank B Hu
  • 通讯作者:
    Frank B Hu
Three decades of the Mediterranean diet pyramid: A narrative review of its history, evolution, and advances
  • DOI:
    10.1016/j.ajcnut.2025.04.036
  • 发表时间:
    2025-07-01
  • 期刊:
  • 影响因子:
    6.900
  • 作者:
    Frank B Hu;Greg Drescher;Antonia Trichopoulou;Walter C Willett;Miguel A Martínez-González
  • 通讯作者:
    Miguel A Martínez-González
Food additive emulsifiers: a new risk factor for type 2 diabetes?
食品添加剂乳化剂:2型糖尿病的新危险因素?
Title page, program participants, and TOC
  • DOI:
    10.3945/ajcn/100.6.1607s
  • 发表时间:
    2014-12-01
  • 期刊:
  • 影响因子:
  • 作者:
    An Pan;Frank B Hu
  • 通讯作者:
    Frank B Hu
Dietary patterns, serum metabolites, and risk of cardiovascular disease in United States Hispanic/Latino adults: a prospective analysis of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
  • DOI:
    10.1016/j.ajcnut.2025.05.008
  • 发表时间:
    2025-07-01
  • 期刊:
  • 影响因子:
    6.900
  • 作者:
    Hongbo Yang;Yi Wang;Kai Luo;Yasmin Mossavar-Rahmani;Christina Cordero;Robert J Ostfeld;Claudia Martinez;Luis Maldonado;Amber Pirzada;Martha Daviglus;Bing Yu;Frank B Hu;Robert C Kaplan;Qibin Qi
  • 通讯作者:
    Qibin Qi

Frank B Hu的其他文献

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{{ truncateString('Frank B Hu', 18)}}的其他基金

Lifestyle Interventions, metabolites, microbiome, and diabetes risk
生活方式干预、代谢物、微生物组和糖尿病风险
  • 批准号:
    10557795
  • 财政年份:
    2021
  • 资助金额:
    $ 48.19万
  • 项目类别:
Administrative Core for the Dietary Biomarkers Development Center at Harvard University
哈佛大学膳食生物标志物开发中心的行政核心
  • 批准号:
    10461132
  • 财政年份:
    2021
  • 资助金额:
    $ 48.19万
  • 项目类别:
Administrative Core for the Dietary Biomarkers Development Center at Harvard University
哈佛大学膳食生物标志物开发中心的行政核心
  • 批准号:
    10649586
  • 财政年份:
    2021
  • 资助金额:
    $ 48.19万
  • 项目类别:
Lifestyle Interventions, metabolites, microbiome, and diabetes risk
生活方式干预、代谢物、微生物组和糖尿病风险
  • 批准号:
    10370323
  • 财政年份:
    2021
  • 资助金额:
    $ 48.19万
  • 项目类别:
Administrative Core for the Dietary Biomarkers Development Center at Harvard University
哈佛大学膳食生物标志物开发中心的行政核心
  • 批准号:
    10289794
  • 财政年份:
    2021
  • 资助金额:
    $ 48.19万
  • 项目类别:
Dietary Interventions, Metabolites, and Risk of Type 2 Diabetes
饮食干预、代谢物和 2 型糖尿病的风险
  • 批准号:
    8760615
  • 财政年份:
    2014
  • 资助金额:
    $ 48.19万
  • 项目类别:
Mediterranean diet, Metabolites, and cardiovascular Disease
地中海饮食、代谢物和心血管疾病
  • 批准号:
    9090169
  • 财政年份:
    2013
  • 资助金额:
    $ 48.19万
  • 项目类别:
Mediterranean diet, Metabolites, and Cardiovascular Disease
地中海饮食、代谢物和心血管疾病
  • 批准号:
    10551729
  • 财政年份:
    2013
  • 资助金额:
    $ 48.19万
  • 项目类别:
Mediterranean diet, Metabolites, and cardiovascular Disease
地中海饮食、代谢物和心血管疾病
  • 批准号:
    8482202
  • 财政年份:
    2013
  • 资助金额:
    $ 48.19万
  • 项目类别:
Mediterranean diet, Metabolites, and cardiovascular Disease
地中海饮食、代谢物和心血管疾病
  • 批准号:
    9388404
  • 财政年份:
    2013
  • 资助金额:
    $ 48.19万
  • 项目类别:

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