Training the next generation of clinical neuroscientists

培训下一代临床神经科学家

• 批准号: 10649573
• 负责人: Rene S. Kahn
• 金额: $ 42.22万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10649573
• 关键词: Clinical; Training; next generation

The last decade has witnessed a surge in new research findings in neuroscience. So far, however, that impressive progress has not translated into more effective treatments, or better outcomes, for patients with serious mental illness. Although this may just be a matter of time, another contributing factor is the lack of physician scientists in the field of clinical neuroscience. Physician scientists are uniquely capable of linking basic science findings to the clinical phenomenology of psychiatric illness. Indeed, scientists like these - with both clinical and research training - are uniquely poised to bridge the gap between basic neurobiology and clinical disease. This combination is critical for advancing our understanding of the neurobiology of psychiatric disorders - and for developing the highly needed disease-modifying treatments for psychiatric illnesses. One of the explanations for the lack of clinician-scientists is the difficulty in obtaining grant funding right after residency. This proposal aims to fill that gap. In a two-three year fellowship we will provide intense research training for a select group of psychiatrists (or PhD psychologists). Upon completion, trainees should be able to apply successfully for individual grants and develop into independent clinical neuroscientists. We aim to create clinician-researchers who can combine clinical knowledge with superior research skills. The long-term goal is to help shape the new generation of leaders in clinical neuroscience. Drs. Kahn, Malaspina and New are each renowned physician scientists who combine clinical expertise with deep research and training experience. This program will fill an important gap in the otherwise impressive translational research program at the Icahn School of Medicine at Mount Sinai (ISMMS), recognized as a top ten innovative research engine worldwide by Nature. Indeed, the Departments of Neuroscience and Psychiatry are ranked #1 and #6 respectively in NIH funding. We already have extensive experience, and a successful track record, in supporting other research career pathways, including a Physician-Scientist residency research track for MD, PhD trainees, and the first Combined Psychiatry Residency and PhD Training program in the US, funded by an NIMH R25 grant, of which Dr. New is PI. We also have 6 K awardees and 2 K99/R00 investigators in our rich training programs. The proposed T32 fellowship program is designed to train psychiatrists and clinical PhDs to formulate original research questions on etiology, pathogenesis, course, treatment and prevention of serious mental illness. Its focus is on patients with schizophrenia and major mood disorders. Each trainee, paired with a mentor, will formulate a career development plan with targeted goals for acquisition of skills, presentations, publications, gathering pilot data, and preparation of proposals for external funding - usually a career development award. Regular meetings, internally and with an external advisory board, will monitor trainee development in relevant milestones. We aim to help fill the dearth in clinical neuroscientists so that the recent advances in neuroscience can be translated into better care for the millions of patients with serious mental illness.

在过去的十年里，神经科学的新研究成果激增。然而，到目前为止， 令人印象深刻的进展并没有转化为更有效的治疗，或更好的结果，为患者， 严重的精神疾病。虽然这可能只是时间问题，但另一个促成因素是缺乏 临床神经科学领域的医生科学家。医生科学家是唯一能够连接 基础科学发现到精神疾病的临床现象学。事实上，科学家们喜欢这些-与 临床和研究培训-都是独一无二的桥梁差距基础神经生物学和 临床疾病这种结合对于促进我们对精神疾病的神经生物学的理解至关重要。 这些研究成果将用于治疗精神疾病，并用于开发急需的改善精神疾病的治疗方法。 缺乏临床科学家的原因之一是在获得资助后很难立即获得资助。 居住权本提案旨在填补这一空白。在为期两三年的奖学金，我们将提供密集的研究 为一组选定的精神科医生（或博士心理学家）进行培训。完成课程后，学员应能 成功申请个人赠款，并发展成为独立的临床神经科学家。我们的目标是创造 能够将联合收割机临床知识与上级研究技能相结合的临床研究人员。长期目标是 帮助塑造临床神经科学的新一代领导者。卡恩博士、马拉斯皮纳博士和纽博士分别是 联合收割机结合临床专业知识和深厚的研究和培训经验的著名医生科学家。 这个项目将填补伊坎学院令人印象深刻的转化研究项目中的一个重要空白 西奈山医学院（ISMMS），被公认为全球十大创新研究引擎， 自然事实上，神经科学系和精神病学系分别在NIH排名第一和第六 经费在支援其他研究方面，我们已有丰富的经验和成功的往绩 职业途径，包括医学博士，博士生的物理学家-科学家居住研究轨道，以及第一个 美国精神病学住院医师和博士培训项目，由NIMH R25资助，其中 博士新的是PI。我们还有6名K获奖者和2名K99/R 00调查员参加我们丰富的培训计划。 拟议的T32奖学金计划旨在培训精神科医生和临床博士， 重性精神疾病的病因、发病机制、病程、治疗和预防等研究问题。其 重点是精神分裂症和严重情绪障碍患者。每一位学员，与一位导师配对，将 制定职业发展计划，其中有针对性的目标是获得技能、演讲、出版物， 收集试点数据，并准备外部供资提案-通常是职业发展奖。 内部和与外部咨询委员会的定期会议将监测受训人员在相关领域的发展情况。 里程碑我们的目标是帮助填补临床神经科学家的缺乏，使最新的进展， 神经科学可以转化为更好地照顾数以百万计的严重精神疾病患者。

项目成果

Toward Personalized Deep Brain Stimulation for Obsessive-Compulsive Disorder.

针对强迫症的个性化深部脑刺激。

• DOI: 10.1016/j.bpsc.2023.01.004
• 发表时间: 2023
• 期刊: Biological psychiatry. Cognitive neuroscience and neuroimaging
• 作者: Fiore,VincenzoG;Smith,AndrewH;Figee,Martijn
• 通讯作者: Figee,Martijn

Transdiagnostic subgroups of cognitive impairment in early affective and psychotic illness.

• DOI: 10.1038/s41386-023-01729-7
• 发表时间: 2024-02
• 期刊: NEUROPSYCHOPHARMACOLOGY
• 影响因子: 7.6
• 作者: Wenzel, Julian;Badde, Luzie;Haas, Shalaila S.;Bonivento, Carolina;Van Rheenen, Tamsyn E.;Antonucci, Linda A.;Ruef, Anne;Penzel, Nora;Rosen, Marlene;Lichtenstein, Theresa;Lalousis, Paris Alexandros;Paolini, Marco;Stainton, Alexandra;Dannlowski, Udo;Romer, Georg;Brambilla, Paolo;Wood, Stephen J.;Upthegrove, Rachel;Borgwardt, Stefan;Meisenzahl, Eva;Salokangas, Raimo K. R.;Pantelis, Christos;Lencer, Rebekka;Bertolino, Alessandro;Kambeitz, Joseph;Koutsouleris, Nikolaos;Dwyer, Dominic B.;Kambeitz-Ilankovic, Lana
• 通讯作者: Kambeitz-Ilankovic, Lana

Predictors of internalized mental health stigma in a help-seeking sample of youth: The roles of psychosis-spectrum symptoms and family functioning.

• DOI: 10.1037/abn0000679
• 发表时间: 2021-08
• 期刊: Journal of abnormal psychology
• 影响因子: 4.6
• 作者: DeLuca JS;Akouri-Shan L;Jay SY;Redman SL;Petti E;Lucksted A;Rouhakhtar PR;Klaunig MJ;Edwards SM;Reeves GM;Schiffman J
• 通讯作者: Schiffman J

Evidence of discontinuity between psychosis-risk and non-clinical samples in the neuroanatomical correlates of social function.

• DOI: 10.1016/j.scog.2022.100252
• 发表时间: 2022-09
• 期刊: Schizophrenia research. Cognition
• 作者: Haas SS;Doucet GE;Antoniades M;Modabbernia A;Corcoran CM;Kahn RS;Kambeitz J;Kambeitz-Ilankovic L;Borgwardt S;Brambilla P;Upthegrove R;Wood SJ;Salokangas RKR;Hietala J;Meisenzahl E;Koutsouleris N;Frangou S
• 通讯作者: Frangou S

A qualitative study on identity in individuals at clinical high risk for psychosis: " … Why does it have to be one thing?".

• DOI: 10.1037/prj0000492
• 发表时间: 2022-03
• 期刊: Psychiatric rehabilitation journal
• 影响因子: 1.9
• 作者: Sarac C;DeLuca JS;Bilgrami ZR;Herrera SN;Myers JJ;Dobbs MF;Haas SS;Todd TL;Srivastava A;Jespersen R;Shaik RB;Landa Y;Davidson L;Pavlo AJ;Corcoran CM
• 通讯作者: Corcoran CM