Imaging Core

成像核心

• 批准号: 10647887
• 负责人: ELIZABETH MORMINO
• 金额: $ 31.39万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10647887
• 关键词: Alzheimer' s Disease; Amyloid; Behavioral; Binding; Biological Markers; Brain; Brain imaging; Caliber; Categories; Cerebrospinal Fluid; Classification; Clinical; Clinical Research; Collaborations; Consult; Consultations; Data; Databases; Diagnosis; Diagnostic; Discipline; Discipline of Nuclear Medicine; Educational workshop; Eligibility Determination; Enrollment; Ensure; Functional Imaging; Functional Magnetic Resonance Imaging; Generations; Genetic; Goals; Hippocampus; Human Resources; Image; Image Analysis; Immunohistochemistry; Infrastructure; Ligands; Link; Magnetic Resonance Imaging; Measures; Mentors; Modeling; National Institute on Alcohol Abuse and Alcoholism; Nerve Degeneration; Neurites; Neurodegenerative Disorders; Neuropsychology; Nuclear Radiology; Participant; Pathogenesis; Persons; Plasma; Positron-Emission Tomography; Process; Proteins; Proteomics; Radiochemistry; Radiology Specialty; Reading; Research; Research Personnel; Resolution; Rest; Scanning; Schools; Source; Testing; Thick; Training; Treatment Efficacy; Work; accurate diagnosis; clinical phenotype; cranium; data management; demographics; diagnostic accuracy; flexibility; glial activation; gray matter; improved; in vivo; innovation; molecular imaging; neuropathology; novel; pre-clinical; skills; statistics; structural imaging; tau Proteins; tool; training opportunity; willingness; β-amyloid burden

1. SUMMARY (Imaging Core) The overall goals of the Imaging Core are to obtain amyloid PET and high caliber MRI data to characterize Stanford ADRC participants along the AD and PD spectrums; to make these data available to a wide range of investigators at Stanford; and to provide training on the acquisition, interpretation, and analysis of imaging data relevant to neurodegenerative disease. The Imaging Core, capitalizing on Stanford's strength in brain imaging and radiochemistry, will focus on incorporation of amyloid PET imaging in conjunction with structural and functional MRI, and enable innovation for the exploration of novel PET targets. Dr. Greicius, the Core Director, has helped advance the application of functional connectivity measures to the study of AD. Dr. Mormino, the co-Director of the Imaging Core, has made contributions to characterizing the preclinical stage of AD using amyloid and tau PET. A second major focus of the Imaging Core will be to make the acquired data available to and readily used by researchers across disciplines and schools at Stanford. The Imaging Core will use the RedTree infrastructure to provide researchers with summary imaging data for PET (global and regional amyloid and tau PET values), structural measures (regional gray matter volume and thickness values), and resting state functional measures (network connectivity). The imaging data will be linked to subjects' ancillary data (including neuropsychological measures, spinal fluid proteins, plasma proteomics, etc.). This will allow the widest possible set of Stanford investigators, with or without imaging expertise, to test hypotheses using the ADRC data. The availability of amyloid PET and MRI data on the majority of clinical core participants will greatly enhance diagnostic accuracy which will fundamentally strengthen any clinical research undertaken at the Stanford ADRC. These imaging data, in conjunction with biofluid data from the Biomarker Core, will also enable classification according to the recent research framework of AD so that Stanford ADRC data can be more readily harmonized with data from other centers.

1.摘要(成像核心) 成像核心的总体目标是获得淀粉样蛋白PET和高口径核磁共振数据来表征 斯坦福大学ADRC参与者的AD和PD光谱；使这些数据适用于广泛的 斯坦福大学的研究人员；并提供成像数据的获取、解释和分析方面的培训 与神经退行性疾病有关。影像核心--充分利用斯坦福在脑成像领域的优势 和放射化学，将专注于将淀粉样蛋白PET成像与结构和 功能磁共振成像，并使探索新的PET靶点的创新成为可能。格雷修斯博士，核心主任， 促进了功能连接措施在AD研究中的应用。莫米诺医生， 影像核心联席主任，为确定AD的临床前阶段做出了贡献 淀粉样蛋白和tau PET。成像核心的第二个主要关注点将是使获取的数据可供 很容易被斯坦福大学各学科和学校的研究人员使用。成像核心将使用 RedTree基础架构可为研究人员提供PET(全球和区域)的汇总成像数据 淀粉样蛋白和tau PET值)、结构测量(区域灰质体积和厚度值)以及 休眠状态功能措施(网络连接)。成像数据将被链接到受试者的辅助 数据(包括神经心理测量、脊髓液蛋白、血浆蛋白质组学等)。这将允许 尽可能广泛的斯坦福大学调查人员，有或没有成像专业知识，以使用 ADRC数据。大多数临床核心参与者的淀粉样蛋白PET和MRI数据的可用性将 大大提高了诊断的准确性，这将从根本上加强在 斯坦福大学发展研究中心。这些成像数据与来自Biomarker Core的生物流体数据一起，还将 根据AD的最新研究框架启用分类，以便斯坦福ADRC数据可以 更容易与来自其他中心的数据协调一致。