Pan Omics and Data Science Core

摘要(泛欧米奇与数据科学核心) 包括单细胞组学在内的多组学技术在环境健康科学(EHS)中的应用 研究继续快速增长，并使用先进的机器学习和统计学习 利用这些数据进行翻译预测的技术正变得越来越重要。因此， 在这些任务中保持领先地位可能是压倒性的。泛文学与数据的目标 科学(Pods)的核心是为密歇根州的调查人员提供全面和创新的支持 生命周期环境暴露和疾病中心(M-LEEAD)为研究设计，样本 准备、分析、解释和整合广泛的基于组学的研究，并教育 他们对可用的机会。Pods Core简化了组学研究的整个过程，允许M- Lead调查人员将把更多的自己的资源投入到解决环境健康问题上 科学问题。特定于生命周期的暴露可能通过下列任何一种方式对人类健康产生有害影响 几种机制，包括表观遗传、遗传、转录、蛋白质组、后基因组、代谢组学和 内收切断术。因此，在新的供资期间，豆荚核心的目标是扩大其在以下两个方面的覆盖范围 支持组学技术，并使用统计和数据科学方法。我们将通过以下方式实现这一目标 在这些领域建立一个紧密的UM专家社区，并对EHS感兴趣/有经验。豆荚核心 目标将通过四个具体目标来实现。首先，我们将提供M-Leead调查人员 在包括技术在内的广泛分子研究的研究设计和实施方面的专业知识 平台选择、样本收集和准备，以及与关键UM资源的接触。第二，我们将 为广泛的组学方法和方法提供生物信息学分析和数据科学服务 综合分析。第三，豆荚核心将通过小说的发展来支持社区 用于新技术的生物信息学方法、工具和协议与技术保持同步 进步。最后，Pods Core对M-Leead中心的教职员工和学生进行组学方面的教育 与EHS研究相关的分析和数据科学，并促进环境和环境保护之间的伙伴关系 科学家和数据科学家。M-Leead调查人员受益于几项免费服务和协作 Pod提供的活动，支持和加强基本问题以及应用和 NIEHS翻译研究框架中的综合。

ABSTRACT (Pan Omics and Data Science Core) The use of multi-omics techniques, including single-cell omics, in environmental health sciences (EHS) research continues to grow rapidly, and the use of advanced machine learning and statistical learning techniques to make translational predictions with these data is becoming ever more essential. As such, staying on the cutting edge with these tasks can be overwhelming. The objective of the Pan Omics and Data Science (PODS) Core is to provide comprehensive and innovative support to investigators in the Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD) for the study design, sample preparation, analysis, interpretation, and integration of a broad range of omics-based studies, and to educate them on available opportunities. The PODS Core streamlines the entire process of an omics study, allowing M- LEEaD investigators to dedicate more of their own resources to answering difficult environmental health science questions. Lifestage-specific exposures may have detrimental effects on human health via any of several mechanisms, including epigenetic, genetic, transcriptomic, proteomic, metagenomic, metabolomic, and adductomic. Thus, in the new funding period the PODS Core aims to broaden its reach both in terms of the omics technologies supported, and the statistical and data science methods used. We will achieve this through building a close-knit community of UM experts in these areas and interest/experience in EHS. The PODS Core objective will be accomplished through four specific aims. First, we will provide M-LEEaD investigators expertise in the study design and implementation of a broad range of molecular studies, including technology platform choice, sample collection and preparation, and engagement with key UM resources. Second, we will provide bioinformatics analysis and data science services for a broad range of omics approaches and integrative analyses. Third, the PODS Core will support the community through development of novel bioinformatics methods and tools and protocols for novel technologies staying apace with technological advancements. Finally, the PODS Core educates M-LEEaD Center faculty, staff, and students on omics assays and data science relevant to EHS research, and promotes partnerships between environmental scientists and data scientists. M-LEEaD investigators benefit from several free services and collaborative events offered by PODS, which enables and strengthens Fundamental Questions and also Application and Synthesis in the NIEHS Translational Research Framework.