Northwestern University Clinical and Translational Science Institute (NUCATS)

西北大学临床与转化科学研究所 (NUCATS)

• 批准号: 10650847
• 负责人: Susanna A McColley
• 金额: $ 53.07万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-12 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10650847
• 关键词: Address; Adolescent; Adult; Basic Science; Brain Neoplasms; Child Health; Childhood; Clinical; Clinical Sciences; Collaborations; Communication; Communities; Complement; Computers; Creativeness; Data Engineering; Data Science; Data Scientist; Discharge Plannings; Discipline; Disparate; Doctor of Philosophy; Economics; Educational Curriculum; Elements; Engineering; Environment; Funding; General Anesthesia; Goals; Health; Individual; Institution; Leadership; Learning; Life Cycle Stages; Machine Learning; Mentors; Minority-Serving Institution; Modernization; Nanotechnology; Patient Care; Pediatric Research; Pediatrics; Positioning Attribute; Postbaccalaureate; Postdoctoral Fellow; Research; Research Personnel; Students; TNFSF15 gene; Talents; Technology; Training; Training Activity; Training Programs; Translating; Translational Research; Underrepresented Minority; Universities; Work; Writing; adolescent health; bridge program; career; doctoral student; experience; improved; innovation; interest; multidisciplinary; novel; novel strategies; pediatrician; peer; post-doctoral training; pre-doctoral; programs; summer research; tool; translational health science

ABSTRACT: The health of children and adolescents is a critical determinant of our nation's health over the entire life course. Yet, research into child health lags behind that for adults. In part, this reflects historical, cultural and economic forces that tend to divert investigators into careers other than pediatric research. To address this concern, the Northwestern University Clinical and Translational Sciences Institute (NUCATS) chose the unique approach of specifically training young investigators to apply engineering solutions to problems in child health. Our overall goal is to generate a community of pediatricians, data scientists and engineers who collaborate across disciplines, using modern technology to improve the health of children and adolescents. The central focus of this continuing and highly successful effort is this Multidisciplinary Training Program in Child and Adolescent Health TL1, which has three specific aims. In Aim 1, we will train 10 postdoctoral fellows in basic science or pediatrics for two years, in a creative and multidisciplinary environment where investigators are equipped to apply innovative engineering approaches to problems in child and adolescent health. The fellows must have a mentor in both pediatrics and engineering. Presently, their projects range from computer-controlled delivery of general anesthesia or using nanotechnology to treat brain tumors, to applying machine learning to optimize discharge planning. This innovative research experience is complemented by mentoring from the TL1 leadership and from their postdoctoral-fellow peers; required foundational elements, which promote communication across traditionally disparate scientific disciplines; required selective components, assigned to individual fellows to optimize their training in pediatric clinical and translational science; and a menu of enrichment opportunities that are optional for each trainee. All of these components include both didactic and experiential approaches. In Aim 2, to expand the pipeline of engineers entering child and adolescent health research, we will provide 2, one-year positions (1 supported by the CTSA and 1 by institutional funds) for predoctoral engineers entering the last year of PhD training, especially those representing underrepresented minorities, as they complete their research and write their thesis. By including engineering trainees who are interested in CTS in the training activities available to our TL1 postdoctoral fellows, we intend to enhance their potential commitment to pediatric translational science. Finally, in Aim 3, we will provide a summer research experience at Northwestern for 4 students in clinical post-baccalaureate programs at a traditionally underrepresented-minority institution. Our experience to date suggests that, with our ongoing involvement after the summer experience, many of these students have been inspired to seek careers in translational research. Together, these aims outline a comprehensive and successful program to increase the number and quality of investigators applying innovative approaches to improving child and adolescent health.

摘要：儿童和青少年的健康是整个国家健康的关键决定因素 生活课程。然而，针对成年人的儿童健康滞后的研究滞后。在某种程度上，这反映了历史，文化和 倾向于将研究人员转移到儿科研究以外的职业的经济力量。解决这个问题 担心，西北大学临床和翻译科学研究所（NUCATS）选择了独特的 专门培训年轻研究人员将工程解决方案应用于儿童健康问题的方法。 我们的总体目标是建立一个协作的儿科医生，数据科学家和工程师社区 跨学科，使用现代技术来改善儿童和青少年的健康。中央 这种持续且非常成功的努力的重点是该儿童的多学科培训计划 青少年健康TL1，具有三个特定目标。在AIM 1中，我们将在基本的10个博士后研究员培训10个博士后研究员 科学或儿科已经两年了，在一个创造性和多学科的环境中 配备有创新的工程方法来解决儿童和青少年健康问题。研究员 必须有儿科和工程学的导师。目前，他们的项目范围从计算机控制 提供全身麻醉或使用纳米技术治疗脑肿瘤，将机器学习应用于 优化排放计划。通过TL1的指导，这种创新的研究经验得到了补充 领导及其后同伴的同伴；需要促进的基础元素 传统上不同的科学学科的交流；所需的选择性组件，分配给 个人研究员优化他们在儿科临床和转化科学领域的培训；和一个菜单 对于每个学员来说都是可选的丰富机会。所有这些组件都包括教学和 体验方法。在AIM 2中，扩大进入儿童和青少年健康的工程师的管道 研究，我们将提供2个一年的职位（1个由CTSA支持，由机构基金支持） 进入博士学位培训最后一年的专业工程师，尤其是代表人数不足的工程师 少数群体完成研究并撰写论文。通过包括工程学员 对我们TL1博士后研究员可用的培训活动感兴趣，我们打算增强他们的 对小儿翻译科学的潜在承诺。最后，在AIM 3中，我们将提供夏季研究 在西北地区，在传统上，在西北地区为4名学生提供了临床后库尔爵士的临床课程课程的经验 代表性不足的少数机构。迄今为止，我们的经验表明，随着我们的持续参与 夏季经验，其中许多学生受到启发，从而寻求转化研究的职业。 这些目标共同概述了一个全面而成功的计划，以增加 采用创新方法来改善儿童和青少年健康的研究人员。

项目成果

Spinal dura mater: biophysical characteristics relevant to medical device development.

• DOI: 10.1080/03091902.2018.1435745
• 发表时间: 2018-03
• 期刊: Journal of medical engineering & technology
• 作者: Nagel SJ;Reddy CG;Frizon LA;Chardon MK;Holland M;Machado AG;Gillies GT;Howard MA 3rd;Wilson S
• 通讯作者: Wilson S

Provider education leads to sustained reduction in pediatric opioid prescribing after surgery.

• DOI: 10.1016/j.jpedsurg.2021.08.004
• 发表时间: 2022-03
• 期刊: Journal of pediatric surgery
• 影响因子: 2.4
• 作者: Slater BJ;Corvin CG;Heiss K;Vandewalle R;Shah SR;Cunningham M;Huang E;Lipskar AM;Denning NL;Dassinger M;Cina RA;Rothstein DH;Kauffman J;Gonzalez R;Ingram MC;Raval MV
• 通讯作者: Raval MV

Enhancing clinical trial development for pediatric kidney diseases.

加强儿科肾脏疾病的临床试验开发。

• DOI: 10.1038/pr.2017.180
• 发表时间: 2017
• 期刊: Pediatric research
• 影响因子: 3.6
• 作者: Schnaper,HWilliam;Flynn,JosephT;Gross,Coleman;Cropp,AnneB;Dehmel,Bastian;Patel,LeahB;Greenbaum,LarryA;Houtsmuller,Elisabeth;Kaskel,Frederick;Moxey-Mims,Marva;Nowak,Karen;Silverstein,Douglas;Thompson,Aliza;Yao,Lynne;Darsey,
• 通讯作者: Darsey,

Development of Optimized Tissue-Factor-Targeted Peptide Amphiphile Nanofibers to Slow Noncompressible Torso Hemorrhage.

• DOI: 10.1021/acsnano.9b09243
• 发表时间: 2020-06-23
• 期刊: ACS nano
• 影响因子: 17.1
• 作者: Klein MK;Kassam HA;Lee RH;Bergmeier W;Peters EB;Gillis DC;Dandurand BR;Rouan JR;Karver MR;Struble MD;Clemons TD;Palmer LC;Gavitt B;Pritts TA;Tsihlis ND;Stupp SI;Kibbe MR
• 通讯作者: Kibbe MR

Scaling of Motor Output, From Mouse to Humans.

• DOI: 10.1152/physiol.00021.2018
• 发表时间: 2019-01
• 期刊: Physiology
• 影响因子: 8.4
• 作者: M. Manuel;M. Chardon;V. Tysseling;C. J. Heckman