University of New Mexico Cancer Center Support Grant

总体构成：新墨西哥大学综合癌症中心 项目摘要/摘要 自2005年获得NCI癌症中心称号，2015年获得NCI综合癌症中心称号以来， 新墨西哥大学综合癌症中心及其联盟合作伙伴Lovelace 生物医学/洛夫莱斯呼吸研究所(LRRI)建立了一种单一的跨学科癌症- 专注于其集水区新墨西哥州(新墨西哥州)的研究企业。与众不同的 中乍特派团的特点包括：1)它所服务的多族裔、城市/农村人口--主要是 西班牙裔/拉丁裔、非西班牙裔白人、美国印第安人和黑人--癌症模式截然不同 发病率和死亡率、巨大的癌症健康差距以及严重的社会经济脆弱性；2) 与美国印第安人(AI)建立深度参与和独特的研究、教育和培训伙伴关系 国家和西班牙裔(H)社区；3)全州范围的癌症监测、筛查登记和独特的远程- 指导促进癌症控制研究的基础设施；以及4)全州临床试验网络，由 作为一个少数民族/服务不足的NCI社区肿瘤学研究计划，参与了该州的大多数 肿瘤学提供者。联合国儿童基金会的使命是减轻癌症负担，战胜巨大的癌症 通过开创性的跨学科研究，了解北卡罗来纳州集水区的健康差异 发现临床和社区干预、有效的双向社区参与、培训 更多元化的癌症工作队伍，并提供特殊的癌症护理。具有广泛的战略规划和 评价，联东综合团大幅改组和加强其领导层，3个研究方案，9 共享资源和临床研究基础设施，以确保中心的持续增长。自2015年以来，33 招募了新成员，设立了23个新职位。该中心的102名成员聚集在一起 3个跨学科、高度翻译的研究项目(癌症控制与人口科学、细胞与 分子肿瘤学和癌症治疗学)，由36,196,038美元的年度直接癌症相关资金支持 资金，其中27 542 340美元为同行审查，8 245 544美元为国家合作组织。额外的NCI为3,009,657美元 合同和补充合同，NCI每年为该中心提供的资金总额为11,255,201美元。联合国儿童基金会的研究高度重视 互动性和影响力(合作出版物在其研究计划中的比例从34%到60%，16% 在高影响力期刊上发表930篇文章，申请136项专利，成立10家新公司)。四个联合国苏丹特派团 这些发现被转化为早期试验，其中一项现在是NCTN NRG的国家试验。公元1361年 2019年，40%的介入治疗应计费用是少数族裔(29%的H人；6%的AI)，情况也是如此 55%的介入性非治疗累积(33%H；12%AI)。在530名学员中，72%是少数族裔/多元化 学者。授予27项合作赠款(包括NCI参与者参与-癌症基因组 测序研究中心，3个专注于环境暴露和癌症病因，都很吸引人 尽管如此，中乍特派团将继续对其集水区和国家产生深远影响。

OVERALL COMPONENT: THE UNIVERSITY OF NEW MEXICO COMPREHENSIVE CANCER CENTER PROJECT SUMMARY / ABSTRACT Since achieving designation as a NCI Cancer Center in 2005 and a NCI Comprehensive Cancer Center in 2015, the University of New Mexico Comprehensive Cancer Center (UNMCCC) and its Consortium Partner, Lovelace Biomedical/The Lovelace Respiratory Research Institute (LRRI), have built a single transdisciplinary cancer- focused research enterprise across its catchment area, the State of New Mexico (NM). The distinguishing characteristics of the UNMCCC include: 1) the multiethnic, urban/rural populations that it serves - primarily Hispanic/Latino, non-Hispanic White, American Indian, and Black - with strikingly different patterns of cancer incidence and mortality, tremendous cancer health disparities, and profound socioeconomic vulnerabilities; 2) deep engagement and unique research and education and training partnerships with American Indian (AI) Nations and Hispanic (H) communities; 3) statewide cancer surveillance, screening registries, and unique tele- mentoring infrastructures that facilitate cancer control research; and 4) a statewide clinical trials network, funded as a Minority/Underserved NCI Community Oncology Research Program, engaging the majority of the state's oncology providers. The UNMCCC mission is to reduce the cancer burden and overcome the tremendous cancer health disparities of the NM catchment area through ground-breaking transdisciplinary research, translation of discoveries to clinical and community interventions, impactful bi-directional community engagement, training of a more diverse cancer workforce, and delivery of exceptional cancer care. With extensive strategic planning and evaluation, the UNMCCC significantly restructured and enhanced its Leadership, 3 Research Programs, 9 Shared Resources, and clinical research infrastructure to assure the Center's continued growth. Since 2015, 33 new Members were recruited and 23 Endowed Positions created. The Center's 102 Members are clustered into 3 interdisciplinary, highly translational Research Programs (Cancer Control & Population Sciences, Cellular & Molecular Oncology, and Cancer Therapeutics), supported by $36,196,038 in annual direct cancer-relevant funding, of which $27,542,340 is peer-reviewed and $8,245,544 is NCI. With $3,009,657 in additional NCI contracts and supplements, total annual NCI funding to the Center is $11,255,201. UNMCCC research is highly interactive and impactful (with collaborative publications ranging from 34-60% in its Research Programs, 16% of 930 publications in high impact journals, 136 patents filed, and 10 new companies launched). Four UNMCCC discoveries were translated to early phase trials, one of which is now a national NCTN NRG trial. Of 1361 accruals in 2019, 40% of interventional treatment accruals were racial/ethnic minorities (29% H; 6% AI), as were 55% of interventional non-treatment accruals (33% H; 12% AI). Among 530 trainees, 72% were minority/diverse scholars. With the awarding of 27 collaborative grants (including a NCI Participant Engagement-Cancer Genome Sequencing Research Center and 3 focused on environmental exposure and cancer causation, all engaging Tribal Nations), the UNMCCC will continue to have a profound impact on its catchment area and the nation.