Examining Neural Modulatory Effects of Serotonergic Psychedelic Compounds in Relation to Neuroticism

检查血清素迷幻化合物与神经质相关的神经调节作用

• 批准号: 10535571
• 负责人: Brandon Weiss
• 金额: $ 5.27万
• 依托单位: IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-11-01 至 2023-07-26
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10535571
• 关键词: Acute; Agonist; Amygdaloid structure; Animal Model; Animals; Binding; Bolus Infusion; Brain; Brain region; Clip; DSM-V; Dose; Fellowship; Functional Magnetic Resonance Imaging; Future; Goals; Hallucinogens; Hippocampus (Brain); Human; Infusion procedures; Intervention; Link; Literature; Magnetic Resonance Imaging; Mental Health; Mental disorders; Methods; Modeling; Molecular; Neurobiology; Neuronal Plasticity; Neurophysiology - biologic function; Neurotic Disorders; Outcome; Patient Self-Report; Pattern; Personality; Personality Traits; Personality inventories; Physiological; Positron-Emission Tomography; Prefrontal Cortex; Process; Psychopathology; Research; Research Personnel; Role; Stress; Structure; Synapses; Synaptic plasticity; Therapeutic Effect; Time; blood oxygen level dependent; density; first-in-human; indexing; movie; negative affect; physical conditioning; psychologic; radioligand; receptor; relating to nervous system; trait

PROJECT SUMMARY/ABSTRACT Serotonergic 2A receptor agonists (“classic psychedelics”) have recently been described as psychoplastogens in view of their selective modulatory effects on neural structure and function. Although this neural modulatory mechanism has been well demonstrated in animal models, researchers are only now examining its role in the living human brain. Understanding processes involving selective and adaptive modulation of neural structure may in the future catalyze important interventions into mental and physical health that harness the brain’s capacity for plasticity. The present proposal leverages a comprehensive set of methods at molecular, functional, and psychological levels of analysis to investigate whether and how psychedelic compounds produce neural plasticity, and whether neural modulatory processes underlie post- acute changes in functional activation and synchrony in regions related to the personality trait neuroticism and adaptive post-acute effects on neuroticism found in the literature. The long-term goal of this line of research is to understand processes underlying selective modulation of neural structure and function. The overall objective is to ascertain whether psychedelic compounds produce neural plasticity indexed by Positron Emission Tomography radioligand indices of synaptic density and functional Magnetic Resonance Imaging activation and synchrony, and whether these changes covary with adaptive changes in neuroticism.

项目总结/摘要 5-羟色胺能2A受体激动剂（“经典迷幻剂”）最近被描述为 Psychoplastogens，鉴于其对神经结构和功能的选择性调节作用。 虽然这种神经调节机制已经在动物模型中得到了很好的证明， 研究人员现在才开始研究它在人类大脑中的作用。理解过程 涉及神经结构的选择性和适应性调节， 重要的心理和身体健康干预措施，利用大脑的能力， 可塑性本提案利用了分子、 功能和心理层面的分析，以调查是否和如何迷幻 化合物产生神经可塑性，以及神经调节过程是否是后 与人格特质相关的区域的功能激活和同步性的急剧变化 神经质和适应后急性神经质的影响在文献中发现。长期 这一系列研究的目标是了解神经元选择性调制的潜在过程。 结构和功能。总体目标是确定迷幻化合物是否 产生由正电子发射断层扫描放射性配体指数指示的神经可塑性 突触密度和功能性磁共振成像激活和同步，以及 这些变化是否与神经质的适应性变化协变。

项目成果

Prevalence and therapeutic impact of adverse life event reexperiencing under ceremonial ayahuasca.

• DOI: 10.1038/s41598-023-36184-3
• 发表时间: 2023-06-09
• 期刊: Scientific reports
• 影响因子: 4.6

Examining the Therapeutic Effect of Ceremonial Ayahuasca on Narcissistic Personality and Antagonistic Externalizing in Adults.

• DOI: 10.1521/pedi.2023.37.2.131
• 发表时间: 2023-04
• 期刊: JOURNAL OF PERSONALITY DISORDERS
• 影响因子: 2.3
• 作者: Weiss, Brandon;Sleep, Chelsea;Miller, Joshua D.;Campbell, W. Keith
• 通讯作者: Campbell, W. Keith

A critical evaluation of QIDS-SR-16 using data from a trial of psilocybin therapy versus escitalopram treatment for depression.

• DOI: 10.1177/02698811231167848
• 发表时间: 2023-07
• 期刊: JOURNAL OF PSYCHOPHARMACOLOGY
• 影响因子: 4.1
• 作者: Weiss, Brandon;Erritzoe, David;Giribaldi, Bruna;Nutt, David J.;Carhart-Harris, Robin L.
• 通讯作者: Carhart-Harris, Robin L.