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Impact of e-cigarette characteristics on reinforcement and tobacco use patterns among current smokers

电子烟特性对当前吸烟者强化和烟草使用模式的影响

基本信息

批准号：
10532189
负责人：
Tracy Taylor Smith
金额：
$ 18.69万
依托单位：
MEDICAL UNIVERSITY OF SOUTH CAROLINA
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-01-15 至 2023-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10532189
关键词：
Aerosols Age Applied Research Area Behavior Biological Markers Carbon Monoxide Characteristics Cigarette Cigarette Smoker Cues Data Development Devices Double-Blind Method Elderly Electronic cigarette Electronics Elements Environment Funding Goals Grant Health Health Benefit Heating Home Individual Laboratories Liquid substance Measurable Medical Mentors Mentorship Methods Nicotine Nicotine Dependence Outcome Participant Patient Self-Report Pattern Pharyngeal structure Policies Prevalence Psychological reinforcement Public Health Randomized Reporting Research Research Methodology Research Priority Research Project Grants Rewards Sampling Smoke Smoker Smoking Smoking Behavior South Carolina Surveys Temperature Testing Tobacco Tobacco Control Research Tobacco Dependence Tobacco use Toxicant exposure Training United States United States National Academy of Sciences Universities Urine Work Writing career cigarette smoke cigarette smoking combustible cigarette design diaries electronic cigarette use electronic liquid experience improved indexing nicotine exposure non-cigarette tobacco product pharmacologic preference programs public health intervention public policy on tobacco recruit reinforcer skills statistics tobacco regulation toxicant uptake young adult

项目摘要

Abstract The prevalence of e-cigarette use has increased dramatically in recent years, particularly among young adults. Because e-cigarettes deliver fewer toxicants than combustible cigarettes, they likely offer improved health outcomes for current smokers who switch completely. However, many smokers who try using e-cigarettes do not switch completely, abandoning e-cigarettes altogether or continuing to use both products. Thus, it is important to understand the factors that lead to these variable tobacco use patterns. One of the primary determinants of e-cigarette uptake and changes in smoking behavior is the reinforcement value delivered by e- cigarette products. Product characteristics that impact nicotine delivery and sensorimotor characteristics are most likely to impact relative reinforcement value. Two of the primary product-level determinants of nicotine delivery and sensorimotor characteristics are the nicotine concentration of e-liquid and the power of the e- cigarette device. The proposed research project will investigate the impact of these characteristics on relative reinforcement value and tobacco use patterns. Current smokers (n=180) will receive an e-cigarette and e-liquid to take home and use over a three-week period. In a double-blind 2x2 design, participants will be randomly assigned to receive a low (3 mg) or high (12 mg) nicotine concentration, and either a low (20 W) or high (50 W) e-cigarette power setting. Participants will return to the lab each week to complete laboratory assessments of relative reinforcement value and provide breath and urine samples for biomarker assessments of smoke and nicotine exposure. Participants will also complete daily electronic diaries assessing tobacco use. Thus, the proposed design includes both lab-based and ecological assessments of reinforcement and tobacco use. Equal numbers of young adult (18-25) and older adult (>25) participants will be recruited to allow for exploratory analyses on the impact of age. The K01 candidate, Dr. Tracy Smith, aims to develop an independent research portfolio that seeks to understand how 1) contextual, individual, and product characteristics contribute to the use of tobacco products, and 2) we can leverage this information to improve public health through tobacco regulation, policy, and public health interventions. The proposed research project described here, along with clear training objectives, will provide the skills necessary to achieve that goal. Training objectives include gaining expertise in non-cigarette tobacco products, tobacco control research, developmental differences in tobacco use, applied research methodologies, and grant-writing. A strong team of mentors have been assembled with expertise in each of these areas. MUSC provides a stellar training environment to allow K-awardees to transition to independent research funding. The training described here is a clear progression from Dr. Smith’s prior work, provides necessary skills for obtaining research independence, and will launch Dr. Smith’s research independence in substantial, measurable ways.!

摘要