SPARKLED: Social Programming Affects Risk in Kids of Latent Endothelial Disease

项目总结/摘要 心血管并发症是美国孕产妇死亡的主要原因。的负担 心血管健康状况不佳的福尔斯不成比例地落在贫困和非白人社区， 结构性种族主义限制了获得高质量护理的机会，从而影响了卫生成果。社会保健方案拟订 (SHP)是一种干预措施，旨在通过赋予社区权力， 解决可改变的健康不良风险因素。青少年的SHP已被证明可以改善健康状况 结果和减轻某些心脏代谢风险因素，包括营养不良和暴露于 社会心理压力源然而，青少年参与SHP对心血管系统的长期影响 健康状况及其对今后怀孕的影响尚不清楚。在这份提案中，我们将与一个全国性的伙伴合作， 公认的课后计划提供SHP（女孩公司，奥马哈），以解决科学文献中的这一差距。 我们假设，具有营养和情绪弹性成分的SHP将对 成人心血管疾病的青少年修饰物。为了验证这一假设，我们将比较营养 抗氧化状态（具体目标1）、头发/唾液皮质醇水平（具体目标2）和血管弹性（具体目标3）。 目的3）在当前/以前的SHP参与者与年龄匹配的对照组。饮食模式和情绪 将使用经验证的问卷来衡量复原力。营养抗氧化状态（ 心血管炎症）将使用液相色谱串联质谱法测量 （LC-MS/MS）。皮质醇水平（心理压力的标志）将在头发和唾液中测量， 酶联免疫测定法（ELISA）。血管反应性（潜伏性内皮疾病的标志物） 使用VENDYS®测试测量。我们的研究将为青少年的SHP设计提供信息，并有助于 通过减少心血管疾病，消除孕产妇死亡率方面的社会人口差异 并发症除了这篇论文的研究，我已经制定了一个培训计划，以丰富我的科学 作为内布拉斯加大学医学中心的一名医生-科学家实习生， （联合国监测委员会）。我将实现以下培训目标： 儿科健康差距，发展独立设计和实施研究项目的能力，掌握 书面和口头科学沟通技巧，并整合我的临床和科学技能。在整个 我的研究生培训，UNMC将提供必要的课程，赠款写作讲习班，研讨会，和其他 提高我的技术专长和专业发展的技能建设机会。一切器皿的银子 本建议书中概述的研究和培训机会将使我成为一名熟练的医生- 科学家和儿科健康差距领域的创新领导者。

Project Summary/Abstract Cardiovascular complications are the leading cause of maternal mortality in the United States. The burden of poor cardiovascular health falls disproportionately on impoverished and non-White communities where structural racism limits access to quality care, thus impacting health outcomes. Social health programming (SHP) is an intervention designed to mitigate adverse social experiences by empowering communities to address modifiable risk factors for poor health. SHP for adolescents has been shown to improve health outcomes and mitigate certain cardiometabolic risk factors, including poor nutrition and exposure to psychosocial stressors. However, the long-term impacts of adolescent participation in SHP on cardiovascular health and its impact on future pregnancies are not known. In this proposal, we will partner with a nationally recognized after-school program offering SHP (Girls Inc., Omaha) to address this gap in the scientific literature. We hypothesize that SHP with nutritional and emotional resiliency components will positively impact adolescent modifiers of adult cardiovascular disease. To test this hypothesis, we will compare nutritional antioxidant status (Specific Aim 1), hair/saliva cortisol levels (Specific Aim 2), and vascular elasticity (Specific Aim 3) in current/former SHP participants versus age-matched controls. Dietary patterns and emotional resiliency will be measured using validated questionnaires. Nutritional antioxidant status (a marker of cardiovascular inflammation) will be measured using liquid chromatography with tandem mass spectrometry (LC-MS/MS). Cortisol levels (a marker of psychological stress) will be measured in hair and saliva using enzyme-linked immunoassay (ELISA). Vascular reactivity (a marker of latent endothelial disease) with be measured using a VENDYS® test. Our research will inform the design of SHP for adolescents and contribute to the elimination of sociodemographic disparities in maternal mortality via the mitigation of cardiovascular complications. In addition to this dissertation research, I have developed a training plan to enrich my scientific and professional development as a physician-scientist trainee at the University of Nebraska Medical Center (UNMC). I will achieve the following training goals: build foundational knowledge and technical skills in pediatric health disparities, develop capacity to independently design and implement research projects, master written and verbal scientific communication skills, and integrate my clinical and scientific skillsets. Throughout my graduate training, UNMC will provide essential coursework, grant writing workshops, seminars, and other skill-building opportunities that enhance my technical expertise and professional development. Altogether, the research and training opportunities outlined in this proposal will empower me to become an adept physician- scientist and an innovative leader in the field of pediatric health disparities.