SPARKLED: Social Programming Affects Risk in Kids of Latent Endothelial Disease

SPARKLED：社交编程会影响儿童潜在内皮疾病的风险

• 批准号: 10663819
• 负责人: Rebecca Slotkowski
• 金额: $ 4.11万
• 依托单位: UNIVERSITY OF NEBRASKA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-19 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10663819
• 关键词: Address; Adolescence; Adolescent; Adult; Affect; Age; Antioxidants; Biological Markers; Black race; Blood Vessels; Cardiovascular Diseases; Cardiovascular system; Carotenoids; Child; Childhood; Clinical; Clinical Markers; Collaborations; Communication; Communities; Community Health; Data; Death Rate; Development; Dietary Practices; Dietary intake; Disease; Disparity; Dyslipidemias; Education; Educational process of instructing; Educational workshop; Elasticity; Emotional; Endothelium; Enzyme-Linked Immunosorbent Assay; Exposure to; Female Adolescents; Future; Goals; Grant; Hair; Health; Healthy Eating; Heart; Heart Diseases; Hydrocortisone; Hypertension; Individual; Inflammation; Informal Social Control; Institutional Racism; Intake; Intervention; Knowledge; Lead; Life; Liquid Chromatography; Literature; Maternal Mortality; Measures; Medical center; Nebraska; Needs Assessment; Nutrient; Nutritional; Nutritional status; Omega-3 Fatty Acids; Outcome; Participant; Persons; Phenotype; Physical activity; Physicians; Poverty; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Psychological Stress; Psychosocial Assessment and Care; Psychosocial Stress; Public Health; Quality of Care; Questionnaires; Reporting; Research; Research Design; Research Project Grants; Risk; Risk Factors; Saliva; Schools; Scientist; Self Efficacy; Serum; Social outcome; Structural Racism; Technical Expertise; Teenagers; Testing; Time; Training; Unhealthy Diet; United States; Universities; Vitamin D; Vitamin E; Woman; Writing; Youth; adverse childhood events; after-school program; cardiometabolic risk; cardiometabolism; cardiovascular health; cardiovascular risk factor; design; dietary; disadvantaged women; empowerment; experience; falls; food insecurity; girls; good diet; health care availability; health disparity; high-risk adolescents; improved; innovation; maternal morbidity; modifiable risk; mortality; nutrition; peer; pregnancy related death; prevent; psychologic; psychosocial; psychosocial stressors; resilience; resilience scale; skills; social; sociodemographic disparity; socioeconomic disadvantage; stress management; tandem mass spectrometry; therapy design; training opportunity; trend; verbal

Project Summary/Abstract Cardiovascular complications are the leading cause of maternal mortality in the United States. The burden of poor cardiovascular health falls disproportionately on impoverished and non-White communities where structural racism limits access to quality care, thus impacting health outcomes. Social health programming (SHP) is an intervention designed to mitigate adverse social experiences by empowering communities to address modifiable risk factors for poor health. SHP for adolescents has been shown to improve health outcomes and mitigate certain cardiometabolic risk factors, including poor nutrition and exposure to psychosocial stressors. However, the long-term impacts of adolescent participation in SHP on cardiovascular health and its impact on future pregnancies are not known. In this proposal, we will partner with a nationally recognized after-school program offering SHP (Girls Inc., Omaha) to address this gap in the scientific literature. We hypothesize that SHP with nutritional and emotional resiliency components will positively impact adolescent modifiers of adult cardiovascular disease. To test this hypothesis, we will compare nutritional antioxidant status (Specific Aim 1), hair/saliva cortisol levels (Specific Aim 2), and vascular elasticity (Specific Aim 3) in current/former SHP participants versus age-matched controls. Dietary patterns and emotional resiliency will be measured using validated questionnaires. Nutritional antioxidant status (a marker of cardiovascular inflammation) will be measured using liquid chromatography with tandem mass spectrometry (LC-MS/MS). Cortisol levels (a marker of psychological stress) will be measured in hair and saliva using enzyme-linked immunoassay (ELISA). Vascular reactivity (a marker of latent endothelial disease) with be measured using a VENDYS® test. Our research will inform the design of SHP for adolescents and contribute to the elimination of sociodemographic disparities in maternal mortality via the mitigation of cardiovascular complications. In addition to this dissertation research, I have developed a training plan to enrich my scientific and professional development as a physician-scientist trainee at the University of Nebraska Medical Center (UNMC). I will achieve the following training goals: build foundational knowledge and technical skills in pediatric health disparities, develop capacity to independently design and implement research projects, master written and verbal scientific communication skills, and integrate my clinical and scientific skillsets. Throughout my graduate training, UNMC will provide essential coursework, grant writing workshops, seminars, and other skill-building opportunities that enhance my technical expertise and professional development. Altogether, the research and training opportunities outlined in this proposal will empower me to become an adept physician- scientist and an innovative leader in the field of pediatric health disparities.

项目摘要/摘要 心血管并发症是美国孕产妇死亡的主要原因。背负着 心血管健康状况不佳主要是由贫困和非白人社区造成的 结构性种族主义限制了获得优质保健的机会，从而影响了健康结果。社会健康规划 (SHP)是一种干预措施，旨在通过授权社区来减少不良社会体验 解决健康状况不佳的可改变的风险因素。为青少年提供的SHP已被证明可以改善健康 结果和缓解某些心脏代谢风险因素，包括营养不良和暴露于 心理社会压力源。然而，青少年参与SHP对心血管的长期影响 健康及其对未来怀孕的影响尚不清楚。在这项提案中，我们将与一家全国性的 公认的课后计划，提供SHP(Girls Inc.，Omaha)来解决科学文献中的这一差距。 我们假设，具有营养和情绪弹性成分的SHP将产生积极影响 成人心血管疾病的青春期修饰者。为了验证这一假设，我们将比较营养成分 抗氧化状态(特定目标1)、头发/唾液皮质醇水平(特定目标2)和血管弹性(特定目标2) 目的3)在现任/前任SHP参与者和年龄匹配的对照组中。饮食模式和情绪 将使用经过验证的调查问卷来衡量恢复能力。营养抗氧化剂状态(一种标志 心血管炎症)将使用液相色谱-串联质谱仪进行测量 (LC-MS/MS)。皮质醇水平(心理压力的标志)将在头发和唾液中使用 酶联免疫测定法(ELISA)。血管反应性(潜伏内皮病的标志)与BE 使用Vendys®测试进行测量。我们的研究将为青少年SHP的设计提供参考，并有助于 通过减少心血管疾病来消除孕产妇死亡率的社会人口学差异 并发症。除了这篇论文的研究，我还制定了一项训练计划，以丰富我的科学 作为内布拉斯加州大学医学中心的医生-科学家实习生和职业发展 (UNMC)。我将实现以下培训目标：建立基础知识和技术技能 儿科健康差距，培养独立设计和实施研究项目的能力，硕士 具有书面和口头的科学沟通能力，并将我的临床和科学技能融为一体。贯穿始终 在我的研究生培训中，UNMC将提供基本的课程作业、赠款撰写研讨会、研讨会和其他 技能建设的机会，提高我的技术专长和职业发展。总而言之， 这份提案中概述的研究和培训机会将使我能够成为一名熟练的医生- 他是一位科学家，也是儿科健康差距领域的创新领导者。