Effects of adversity and cultural protective factors on depression-related brain function in Mexican-origin individuals

逆境和文化保护因素对墨西哥裔个体抑郁相关脑功能的影响

• 批准号: 10567682
• 负责人: Johnna Rose Swartz
• 金额: $ 8.41万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-15 至 2024-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10567682
• 关键词: Address; Adolescence; Angelica; Brain; Development; Developmental Process; Economics; Ensure; Fellowship; Functional Magnetic Resonance Imaging; Future; Goals; Grant; Growth; Human Development; Individual; Intervention; Latino Population; Manuscripts; Mediating; Mental Depression; Mental Health; Mental disorders; Mexican; Mission; Modeling; National Institute of Mental Health; Parents; Positioning Attribute; Process; Publishing; Research; Research Methodology; Research Personnel; Research Training; Risk; Training; Universities; Writing; allostatic load; career; career development; depressive symptoms; doctoral student; ethnic identity; graduate student; improved; neuroimaging; neuromechanism; novel; parent grant; perceived discrimination; professor; prospective; protective factors; relating to nervous system; reward processing; skills; social exclusion; statistics; young adult

PROJECT SUMMARY/ABSTRACT This application is a Research Supplement to R01 MH123530. This application proposes a two-year research and training plan for Angelica Carranza, a PhD student in Human Development at UC Davis. The aim of the parent R01 is to establish the association between adversity in adolescence and depression symptoms and allostatic load in young adulthood for those of Mexican origin, identify neural mechanisms mediating these associations, and discover protective factors that can mitigate these processes of risk. The proposed Research Supplement will expand on the proposed research but remain within the scope of the original parent grant by addressing two research aims. First, to use growth curve modeling to examine how trajectories of economic hardship and perceived discrimination in early/mid adolescence prospectively predict neural connectivity associated with reward processing and social exclusion in late adolescence. Second, to examine how two potential cultural protective factors for Mexican-origin individuals, ethnic identity and familism, moderate associations between adversity and neural connectivity. The proposed Research Supplement will also support Ms. Angelica Carranza in accomplishing the following four training goals: 1) developing expertise in longitudinal statistics, particularly growth curve modeling, 2) advanced training in fMRI analysis, 3) training in culturally- sensitive research methodology for Latino populations and development of expertise in culturally-specific protective factors for mental health in Latino populations, and 4) career development including writing and publishing manuscripts and grant writing. The proposed research and training plan will ensure that Ms. Carranza has the skills needed to pursue her future career goals of obtaining a postdoctoral fellowship and, later, a position as a professor at a research university.

项目摘要/摘要 本申请是对R01 MH123530的研究补充。这份申请提出了为期两年的 加州大学戴维斯分校人类发展博士生Angelica Carranza的研究和培训计划。其目的是 父母R01的目的是在青春期的逆境和抑郁症状之间建立联系 和墨西哥血统的年轻人的恒定负荷，确定调节这些的神经机制 关联，并发现可以减轻这些风险过程的保护性因素。建议的研究 补助金将在拟议研究的基础上扩大，但仍在原家长拨款的范围内 解决两个研究目标。首先，使用增长曲线建模来检验经济轨迹如何 青春期早期/中期的困难和知觉歧视可预测神经连通性 与青春期后期的奖励处理和社会排斥有关。第二，考察两个 墨西哥裔个人潜在的文化保护因素，种族认同和家族主义，适度 逆境和神经连通性之间的联系。拟议的研究补编也将支持 Angelica Carranza女士完成了以下四个培训目标：1)发展纵向和纵向的专门知识 统计，特别是增长曲线建模，2)功能磁共振分析高级培训，3)文化培训- 针对拉美裔人口的敏感研究方法和在文化方面的专门知识开发 拉美裔人口心理健康的保护因素，以及4)职业发展，包括写作和 出版稿件和赠款写作。拟议的研究和培训计划将确保Carranza女士 拥有追求未来职业目标所需的技能，即获得博士后奖学金，然后获得一份工作 作为研究型大学的教授。