Advancing Tobacco Regulatory Science to Reduce Health Disparities

推进烟草监管科学以减少健康差距

• 批准号: 10665866
• 负责人: KURT M. RIBISL
• 金额: $ 392万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-30 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10665866
• 关键词: Address; Adult; Asian; Attitude; Behavior; Belief; Bisexual; Black race; Cigar; Cigarette; Communication; Disadvantaged; Disparity; Electronic cigarette; Epidemic; Funding; Gays; Goals; High Prevalence; Hispanic; Income; Individual; Lesbian; Lesbian Gay Bisexual; Low income; Marketing; Menthol; Mentorship; Pattern; Policies; Population; Population Heterogeneity; Postdoctoral Fellow; Predisposition; Prevalence; Prevention; Public Health; Reduce health disparities; Regulation; Research; Research Personnel; Research Project Grants; Safety; Sampling; Science; Seasons; Smoke; Smoker; Testing; Tobacco; Tobacco Industry; Tobacco use; Training; United States; United States National Institutes of Health; Youth; aged; career; cigarette smoking; cigarillos; design; electronic cigarette use; health disparity; knowledge base; low socioeconomic status; models and simulation; mortality disparity; multidisciplinary; non-cigarette tobacco product; novel; pre-doctoral; programs; reduce tobacco use; smoking cessation; success; tobacco flavor; tobacco products; tobacco regulation; tobacco regulatory science; vaping; young adult

ABSTRACT: OVERALL The US has made decades of progress in reducing cigarette smoking, but notable disparities persist in menthol flavored product use and in the use of non-cigarette tobacco products, including little cigars, cigarillos, and e- cigarettes. We propose the U54 Program Project, “Advancing Tobacco Regulatory Science to Reduce Health Disparities” to address this gap. The Integrative Theme of our UNC TCORS is building the science for effective regulation of and communication about tobacco products disproportionately used by priority populations – flavored tobacco products and e-cigarettes. Our integrated set of four Research Projects seek to understand the impact of regulations and communication campaigns on those disadvantaged by tobacco use disparities, including Black; lower-socioeconomic status (SES); and lesbian, gay, or bisexual (LGB) populations; and youth and young adults. Our ultimate goal is to further FDA and NIH efforts to protect public health through regulation of tobacco products. UNC TCORS’ research will provide essential evidence to guide the FDA as it implements bans on menthol cigarettes and flavored cigars, develops communication campaigns, and addresses the youth vaping epidemic. We propose four Specific Aims: 1) Develop and evaluate the impact of communication campaigns to discourage tobacco product use in diverse populations (Projects 1, 2, 4); 2) Understand the public health impact of flavored tobacco product bans in diverse populations and the conditions under which they are most likely to be most effective (Projects 2 and 3); 3) Build trainees’ capacity to contribute to the field of tobacco regulatory science through training, mentorship, and pilot funding for a diverse and multidisciplinary group of pre-doctoral fellows, post-doctoral fellows, and early-stage investigators (Projects 1-4, Career Enhancement Core); 4) Inform FDA regulation of menthol cigarette and flavored cigar bans and communication campaigns through active dissemination of TCORS scientific findings (Projects 1-4, Administrative Core). Project 1 will develop a novel communication campaign to discourage young adult little cigar and cigarillo use. Project 2 will evaluate whether a menthol cigarette ban could be amplified by a quit smoking campaign to help menthol smokers quit, including Black and LGB smokers. Project 3 will build a microsimulation model to estimate the public health impact of a federal flavored cigar ban on tobacco use, mortality, and health disparities. Project 4 will test the ability of vaping prevention video ads with promising features to reduce susceptibility to vaping among youth and young adults. The Research Projects will receive support from two Cores: Administrative and Career Enhancement (which includes Pilot Research Projects). Our multidisciplinary group of seasoned regulatory science researchers will provide actionable information to inform FDA regulations and communication campaigns.

摘要：总体 美国在减少吸烟方面取得了数十年的进步，但在精神病中显着差距仍然存在 使用调味的产品使用以及使用非烟的烟草产品，包括小雪茄，雪茄和E- 香烟。我们提出了U54计划项目，“促进烟草监管科学以减少健康 解决这一差距的差异。我们UNC TCOR的综合主题是为 优先使用的有效调节烟草产品的沟通和沟通不成比例 种群 - 引发烟草产品和电子烟。我们集成的四个研究项目试图 了解法规和沟通运动对烟草使用灾难的人的影响 差异，包括黑色；低社会经济状况（SES）；和女同性恋，同性恋或双性恋（LGB） 人口；以及青年和年轻人。我们的最终目标是进一步的FDA和NIH努力保护公众 通过调节烟草产品的健康。 UNC TCORS的研究将提供基本证据来指导 FDA在精神病香烟和调味的公民上实施禁令，发展沟通 竞选活动，并解决了青年烟流行的问题。我们提出了四个具体目标：1）发展和 评估沟通运动对劝阻烟草产品使用的影响 （项目1、2、4）； 2）了解在潜水员中引发烟草产品禁令的公共卫生影响 人口及其最有可能最有效的条件（项目2和3）； 3）构建 受训者通过培训，指导和飞行员为烟草监管科学领域做出贡献的能力 为潜水者和多学科的博物馆前研究员，博士后研究员和早期阶段的资助 调查人员（项目1-4，职业增强核心）； 4）告知FDA对精神病香烟的调节和 通过主动传播TCORS科学发现，调味的雪茄禁令和交流活动 （项目1-4，行政核心）。项目1将开展一项新颖的沟通运动以劝阻 年轻的成人小雪茄和雪茄使用。项目2将评估薄荷香烟禁令是否可能是 受到戒烟运动的放大，以帮助薄荷醇吸烟者戒烟，包括黑人和LGB吸烟者。项目 3将建立一个微模拟模型，以估计联邦调味雪茄禁令对公共卫生的影响 烟草使用，死亡率和健康差异。项目4将测试使用预防视频广告的能力 有前途的功能可以减少青年和年轻人对烟的敏感性。研究项目 将获得两个核心的支持：行政和职业增强（包括试点研究 项目）。我们多学科的经验丰富的监管科学研究人员将提供可行的 信息以告知FDA法规和沟通活动。