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BRAIN CONNECTS: Center for Mesoscale Connectomics

大脑连接：中尺度连接组学中心

基本信息

批准号：
10664257
负责人：
TANER AKKIN
金额：
$ 390.57万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-15 至 2028-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10664257
关键词：
Anatomy Attention Axon Behavior Brain Brain Mapping Brain region Central Nervous System Cognition Communication Complex Computer Analysis Data Data Analyses Data Collection Data Set Decision Making Diffusion Diffusion Magnetic Resonance Imaging Disease Fiber Foundations Funding Goals Grain Human Image Imaging Techniques Injections Joints Label Link Literature Macaca Macaca mulatta Magnetic Resonance Imaging Maps Methods Minnesota Modality Modeling Neural Pathways Neuroanatomy Neurons Optical Coherence Tomography Parietal Parietal Lobe Pattern Population Protocols documentation Research Personnel Resolution Structure Techniques Tissues Universities Variant Visualization connectome data acquisition executive function fluorescence imaging frontal lobe human subject in vivo meter multimodality neural network nonhuman primate novel optical imaging tool tractography

项目摘要

PROJECT SUMMARY To understand complex neural pathways and networks and their remarkable ability to generate human behaviors, it is critical to precisely map brain connectomics in vivo. We propose to make significant advances in such brain mapping by founding the Center for Mesoscale Connectomics (CMC). We will first map the mesoscale connections between the frontal and parietal cortices. These connections likely subserve higher-order functions such as attention, decision-making, prospection, and executive control. One key, underappreciated feature of cortical connectivity is its specific variations within a given brain region, further supporting the critical need for descriptions of connectivity at a finer scale. Unfortunately, there has traditionally been a major gap in our pursuit of creating a human brain “wiring diagram” at high spatial resolution, especially since the gold standard for mesoscale brain connectivity, anatomical tract-tracing, cannot be performed in humans. Moreover, techniques that can be applied to humans, such as diffusion MRI tractography, may not recapitulate anatomical connectivity at this scale. Due to this gap, we are lacking an accurate wiring diagram of the human brain that can only be obtained through a multi-modal, cross-species, multi-scale approach. Here, we propose to combine advanced anatomical tract-tracing (Aim 1), polarization-sensitive optical coherence tomography (PS-OCT) (Aim 2), and ultra-high field diffusion tractography (Aim 3) to create such accurate wiring diagrams of human and macaque brains while bridging spatial resolutions and species. Importantly, we will computationally bridge species, methods, and spatial scales via state-of-the art registration and joint (multimodal) modeling of fiber orientations. Subsequently, the remarkable amount of information available in each dataset will be further enhanced using optimized tractography methods. At the end of the proposed funding period, we expect to have complete maps of the mesoscale organization of fronto-parietal connections. We will be poised to apply our multimodal, cross-species methods brain-wide, including both cortical and subcortical circuits. Importantly, the foundation will be laid for computing noninvasive, in vivo, accurate, mesoscale connectivity maps of whole human brains through dMRI tractography, which will allow researchers to link brain connectivity with cognition, behavior, and disease.

项目总结