Activation of GDF9 regulates human folliculogenesis

GDF9 的激活调节人类卵泡发生

• 批准号: nhmrc : 1024358
• 负责人: A/Pr Craig Harrison
• 金额: $ 35.45万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/activation-gdf9-regulates-human-folliculogenesis/110343
• 关键词: Activation; GDF9; regulates; human; folliculogenesis

GDF9 is a key regulator of fertility in female mammals, as it controls the process of folliculogenesis. In this grant, we will demonstrate the importance of GDF9 in human folliculogenesis, determine the mechanisms that activate GDF9 and show why aberrant GDF9 activation leads to ovarian disorders. Collectively, the outcomes of this proposal will increase our understanding of the fundamental mechanisms that regulate ovarian folliculogenesis and provide new avenues to manipulate this process.

GDF9是雌性哺乳动物生育力的关键调节因子，因为它控制卵泡发生的过程。在这项研究中，我们将证明GDF9在人类卵泡发生中的重要性，确定激活GDF9的机制，并说明为什么异常的GDF9激活会导致卵巢疾病。总的来说，这一建议的结果将增加我们对调节卵泡发生的基本机制的理解，并提供新的途径来操纵这一过程。