Control of TGF-beta superfamily signalling in human disease

人类疾病中TGF-β超家族信号传导的控制

• 批准号: nhmrc : 1013533
• 负责人: A/Pr Craig Harrison
• 金额: $ 29.6万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/control-tgf-beta-human-disease/109724
• 关键词: Control; TGF; beta; superfamily; signalling

Members of the transforming growth factor ? (TGF-?) family of proteins play crucial roles in adult tissue homeostasis. In recent years a new paradigm has emerged suggesting that inhibition of TGF-? signalling could be an effective strategy for restoring homeostasis in disease-affected tissues. Dr Harrison’s overall research strategy is based on this concept, and is particularly focussed on developing specific antagonists of individual TGF-? proteins.

转型增长因素的成员？(TGF-?)蛋白质家族在成体组织内稳态中起着至关重要的作用。近年来，一个新的范例已经出现，表明抑制TGF-？信号传导可能是恢复受疾病影响的组织内稳态的有效策略。哈里森博士的总体研究策略是基于这一概念，并且特别关注开发个体TGF-？的特异性拮抗剂。proteins.