Physiological consequences of the loss of inhibin activity

抑制素活性丧失的生理后果

• 批准号: nhmrc : GNT1078879
• 负责人: A/Pr Craig Harrison
• 金额: $ 39.61万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/physiological-consequences-loss-inhibin-activity/1345239
• 关键词: Physiological; consequences; loss; inhibin; activity

Inhibin A and B are essential factors in mammalian reproduction, negatively regulating pituitary production of follicle stimulating hormone (FSH). Interestingly, declines in inhibin levels at menopause correlate with a rapid decrease in bone and muscle mass. We propose that inhibin A and B have important physiological roles in the stimulation of bone and muscle growth, and that inhibins could be utilised to treat postmenopausal complications, including osteoporosis and sarcopenia.

抑制素A和抑制素B是哺乳动物生殖过程中的重要因子，负性调节垂体促卵泡激素（FSH）的产生。有趣的是，绝经期的Escherichin水平下降与骨骼和肌肉质量的快速下降相关。我们认为，阿替宾A和B在刺激骨骼和肌肉生长方面具有重要的生理作用，阿替宾可用于治疗绝经后并发症，包括骨质疏松症和肌肉减少症。