Physiological consequences of the loss of inhibin activity
Physiological consequences of the loss of inhibin activity
批准号:
nhmrc : GNT1078879
负责人:
A/Pr Craig Harrison
金额:
$39.61万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2015
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2015-01-01 至 2017-12-31
中文摘要
抑制素A和抑制素B是哺乳动物生殖过程中的重要因子,负性调节垂体促卵泡激素(FSH)的产生。有趣的是,绝经期的Escherichin水平下降与骨骼和肌肉质量的快速下降相关。我们认为,阿替宾A和B在刺激骨骼和肌肉生长方面具有重要的生理作用,阿替宾可用于治疗绝经后并发症,包括骨质疏松症和肌肉减少症。
英文摘要
Inhibin A and B are essential factors in mammalian reproduction, negatively regulating pituitary production of follicle stimulating hormone (FSH). Interestingly, declines in inhibin levels at menopause correlate with a rapid decrease in bone and muscle mass. We propose that inhibin A and B have important physiological roles in the stimulation of bone and muscle growth, and that inhibins could be utilised to treat postmenopausal complications, including osteoporosis and sarcopenia.
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