The importance of the blood-testis barrier in human infertility

血睾屏障在人类不孕症中的重要性

• 批准号: nhmrc : 1124606
• 负责人: A/Pr Craig Harrison
• 金额: $ 38.31万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/importance-blood-testis-human-infertility/947395
• 关键词: importance; blood; testis; barrier; human

The blood-testis barrier (BTB) shields developing sperm from the circulation and immune system, which would see them as ‘foreign’. Loss of BTB function leads directly to infertility. Curiously, how the BTB ‘opens’ and ‘closes’ to allow entry without causing a ‘leak’ is unknown. We believe that activin A is the main gatekeeper, but this growth factor is also important in inflammation. Our goals are to show how activin A allows sperm cells entry, and how inflammatory diseases impact the BTB.

血液-睾丸屏障(BTB)保护发育中的精子不受循环和免疫系统的影响，后者会将它们视为“外来”精子。BTB功能丧失直接导致不孕不育。奇怪的是，BTB是如何“打开”和“关闭”以允许进入而不造成“泄漏”的，这一点尚不清楚。我们认为激活素A是主要的看门人，但这种生长因子在炎症中也很重要。我们的目标是展示激活素A如何允许精子细胞进入，以及炎症性疾病如何影响BTB。