The importance of the blood-testis barrier in human infertility
The importance of the blood-testis barrier in human infertility
批准号:
nhmrc : 1124606
负责人:
A/Pr Craig Harrison
金额:
$38.31万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2017
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2017-01-01 至 2019-12-31
中文摘要
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英文摘要
The blood-testis barrier (BTB) shields developing sperm from the circulation and immune system, which would see them as ‘foreign’. Loss of BTB function leads directly to infertility. Curiously, how the BTB ‘opens’ and ‘closes’ to allow entry without causing a ‘leak’ is unknown. We believe that activin A is the main gatekeeper, but this growth factor is also important in inflammation. Our goals are to show how activin A allows sperm cells entry, and how inflammatory diseases impact the BTB.
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The importance of the blood-testis barrier in human infertility
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批准号:nhmrc : GNT1124606
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项目类别:Project Grants
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资助金额:$56.1万
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财政年份:2017
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负责人:A/Pr Craig Harrison
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依托单位:
Therapeutic potential of transforming growth factor-beta proteins for the diagnosis and treatment of female infertility
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批准号:nhmrc : 1121504
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项目类别:Project Grants
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资助金额:$64.44万
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财政年份:2017
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负责人:A/Pr Craig Harrison
-
依托单位:
Therapeutic potential of transforming growth factor-beta proteins for the diagnosis and treatment of female infertility
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批准号:nhmrc : GNT1121504
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项目类别:Project Grants
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资助金额:$94.3万
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财政年份:2017
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负责人:A/Pr Craig Harrison
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依托单位:
Targeting Activins to treat cachexia
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批准号:nhmrc : 1078907
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项目类别:Project Grants
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资助金额:$46.44万
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财政年份:2015
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负责人:A/Pr Craig Harrison
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依托单位:
Physiological consequences of the loss of inhibin activity
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批准号:nhmrc : 1078879
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项目类别:Project Grants
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资助金额:$40.88万
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财政年份:2015
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负责人:A/Pr Craig Harrison
-
依托单位:
Physiological consequences of the loss of inhibin activity
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批准号:nhmrc : GNT1078879
-
项目类别:Project Grants
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资助金额:$39.61万
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财政年份:2015
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负责人:A/Pr Craig Harrison
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依托单位:
Targeting Activins to treat cachexia
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批准号:nhmrc : GNT1078907
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项目类别:Project Grants
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资助金额:$67.19万
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财政年份:2015
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负责人:A/Pr Craig Harrison
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依托单位:
Activation of GDF9 regulates human folliculogenesis
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批准号:nhmrc : 1024358
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项目类别:Project Grants
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资助金额:$35.45万
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财政年份:2012
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负责人:A/Pr Craig Harrison
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依托单位:
Modulation of microRNA activity in the testis: a new paradigm for male fertility?
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批准号:nhmrc : 1009144
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项目类别:Project Grants
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资助金额:$27.95万
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财政年份:2011
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负责人:A/Pr Craig Harrison
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依托单位:
Development of a specific activin antagonist for therapeutic applications
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批准号:nhmrc : 1006488
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项目类别:NHMRC Project Grants
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资助金额:$33.63万
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财政年份:2011
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负责人:A/Pr Craig Harrison
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依托单位:
Control of TGF-beta superfamily signalling in human disease
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批准号:nhmrc : 1013533
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项目类别:Career Development Fellowships
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资助金额:$29.6万
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财政年份:2011
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负责人:A/Pr Craig Harrison
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依托单位:
The role of growth differentiation factor 9 (GDF9) in human fertility
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批准号:nhmrc : 627151
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项目类别:NHMRC Project Grants
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资助金额:$37.93万
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财政年份:2010
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负责人:A/Pr Craig Harrison
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依托单位:
Targeting the TGF-beta signalling pathway to improve muscle growth and development in muscular dystrophy
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批准号:nhmrc : 566820
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项目类别:NHMRC Project Grants
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资助金额:$35.13万
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财政年份:2009
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负责人:A/Pr Craig Harrison
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依托单位:
Discriminating the roles of inhibin A and B in reproductive systems
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批准号:nhmrc : 494804
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项目类别:NHMRC Project Grants
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资助金额:$20.84万
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财政年份:2008
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负责人:A/Pr Craig Harrison
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依托单位:
Antagonism of activin and TGF-B signalling: mechanisma and potential biological applications
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批准号:nhmrc : 441125
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项目类别:Career Development Fellowships
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资助金额:$29.78万
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财政年份:2007
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负责人:A/Pr Craig Harrison
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依托单位:
Activin type II receptor antagonists: mechanism of action and biological applications
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批准号:nhmrc : 388920
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项目类别:NHMRC Project Grants
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资助金额:$33.82万
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财政年份:2006
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负责人:A/Pr Craig Harrison
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依托单位:
Functional mapping of receptor specific domains of human inhibin
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批准号:nhmrc : 169013
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项目类别:Early Career Fellowships
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资助金额:$21.89万
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财政年份:2001
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负责人:A/Pr Craig Harrison
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依托单位:
国内基金
海外基金
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