Cardiorenal and Metabolic Diseases Research Center

整体 项目总结/摘要 心血管（CV）、肾脏和代谢性疾病密不可分，是导致死亡的主要原因 和发病率，特别是在密西西比，它在全国的流行率最高， 疾病肾脏疾病和代谢疾病通常聚集在一起，并且高度相互依赖。肥胖 以及相关的代谢紊乱，如糖尿病，是CV和肾脏疾病的主要原因。 肾功能异常是高血压的一个重要原因，也是高血压的一个结果，高血压是高血压的一个关键风险因素。 心血管疾病，如冠状动脉疾病和中风。了解CV之间的复杂关系， 肾脏和代谢疾病以及开发新的治疗方法需要研究范式的转变 它采用多学科综合方法，结合基础，临床和人口的努力 科学家COBRE第三阶段提案的主要目标是扩大第一阶段和第二阶段的成功， 发展一个领先的肾脏和代谢疾病研究中心（CMDRC），汇集了 由基础、临床和人口科学家组成的多学科小组，致力于共同的协同主题， 以促进他们的合作。第三阶段的具体目标是：1）进一步发展CMDRC基础设施， 一个组织良好的高生产力的试点项目计划（PPP），和可持续的研究核心设施， 培养卓越的基础，临床和人口研究在心肾和代谢疾病，并增加 CMDRC研究人员获得NIH和其他国家生物医学研究机构独立资助的竞争力 2）加强CMDRC的指导和教育计划，为PPP提供支持 调查人员以及其他有前途的研究人员，使他们能够成为生产力，独立， 研究人员也是多学科研究团队的有效合作者; 3）扩大我们的管道 不同的博士后研究员和学生在尖端的心肾和代谢疾病的研究培训 因此，他们成为该领域的下一代研究人员;主要重点是招聘， 通过与当地机构的伙伴关系，并利用 在UMMC的培训计划; 4）加强合作和互动之间建立和初级 来自UMMC心肾和代谢疾病多个学科的研究者，其他IDEA支持 方案和外部合作伙伴。这些互动将利用UMMC和其他IDEA提供的资源 5）进一步扩大高生产力，壁外资助的心肾和代谢项目的数量， 疾病研究人员在UMMC通过利用机构资源，招募更多的新教师， 在临床和转化研究方面的专业知识，以及在CMDCR专业知识存在差距的领域。的 CMDRC一直是显着扩大心肾和代谢疾病研究的主要驱动力， 密西西比。第三阶段的支持将扩大和确保我们努力的可持续性，以发展一个高产的 CMDRC致力于通过研究，发现和创新来改善生活。

OVERALL PROJECT SUMMARY/ABSTRACT Cardiovascular (CV), renal and metabolic diseases are inextricably linked and are the leading causes of mortality and morbidity in the U.S., especially in Mississippi which has the highest prevalence in the nation of these diseases. Cardiorenal and metabolic disorders usually cluster together and are highly interdependent. Obesity and associated metabolic disorders, such as diabetes mellitus, are major causes of CV and renal disease. Abnormal kidney function is an important cause as well as a consequence of hypertension, a key risk factor for CV diseases such as coronary artery disease and stroke. Understanding the complex relationships among CV, renal, and metabolic disorders and developing new therapeutic approaches requires a paradigm shift in research that incorporates multidisciplinary integrated approaches, combining the efforts of basic, clinical and population scientists. A major objective of this Phase 3 COBRE proposal is to amplify the success of Phases 1 and 2 in developing a leading Cardiorenal and Metabolic Diseases Research Center (CMDRC) that brings together a multidisciplinary group of basic, clinical and population scientists working on a common synergistic theme, and to facilitate their collaborations. The specific aims for Phase 3 are: 1) To further develop CMDRC infrastructure, a well-organized highly productive Pilot Projects Program (PPP), and sustainable research core facilities that foster excellence in basic, clinical, and population research in cardiorenal and metabolic diseases and increased competitiveness of CMDRC investigators for independent funding from NIH and other national biomedical research programs; 2) To enhance CMDRC mentoring and education programs that provide support for PPP investigators as well as other promising researchers so that they can become productive, independent investigators who are also effective collaborators on multidisciplinary research teams; 3) To amplify our pipeline of diverse postdoctoral fellows and students trained in cutting-edge cardiorenal and metabolic diseases research so they become the next generation of researchers in this field; major emphasis is placed on recruiting and mentoring underrepresented minority investigators through partnerships with local institutions and by leveraging training programs at UMMC; 4) To enhance collaborations and interactions among established and junior investigators from multiple disciplines in cardiorenal and metabolic diseases at UMMC, other IDeA supported programs, and external partners. These interactions will leverage resources provided by UMMC and other IDeA programs; 5) To further expand the number of highly productive, extramurally funded cardiorenal and metabolic disease researchers at UMMC by leveraging institutional resources to recruit additional new faculty with expertise in clinical and translational research, and in areas where there are gaps in CMDCR expertise. The CMDRC has been a major driver for marked expansion of cardiorenal and metabolic diseases research in Mississippi. Phase 3 support will amplify and ensure sustainability of our efforts to develop a highly productive CMDRC dedicated to improving lives through research, discovery, and innovation.