Cadiorenal and Metabolic Diseases Research Center

描述（由申请人提供）： 心血管疾病、肾脏疾病和代谢疾病是密不可分的，并且是美国死亡率和发病率的主要原因，特别是在密西西比，该地区这些疾病的患病率在全国最高。这些疾病通常聚集在一起，并且高度相互依赖。肥胖和相关的代谢紊乱，如糖尿病，是心血管和肾脏疾病的主要原因。肾功能异常是高血压的重要原因和后果，高血压是心血管疾病如冠状动脉疾病和中风的关键危险因素。了解心血管、肾脏和代谢疾病之间的复杂关系，并开发新的治疗方法，需要在研究中实现范式转变，纳入多学科综合方法，结合基础、临床和人口科学家的努力。该提案的一个主要目标是建立一个国际公认的肾脏和代谢疾病研究中心（CMDRC），该中心汇集了一个多学科的基础，临床和人口科学家小组，致力于共同的协同主题，并促进他们的合作。具体目标是：1）发展基础设施和核心设施， 在心肾和代谢疾病的基础、临床和人口研究方面取得卓越成就，并提高初级研究人员从NIH和其他国家生物医学研究项目获得独立资助的竞争力。2)为有前途的初级研究者制定指导和教育计划，并提供研究支持，使他们能够成为富有成效的独立研究者，成功地竞争NIH的资金; 3）实现初级研究者在本提案中描述的研究项目的具体目标，并促进他们的职业发展; 4）培养多元化的博士前研究生，医学生和博士后研究员的管道，他们在尖端的心肾和代谢疾病研究中接受培训，使他们成为该领域的下一代研究人员;主要重点将放在通过与当地少数民族机构的伙伴关系招募和指导代表性不足的少数民族研究人员; 5）加强UMMC心肾和代谢疾病多学科既定研究人员之间的合作和互动，以及与外部合作伙伴的合作; 6）通过招募具有临床和转化研究以及新兴技术（如体内成像，分子遗传学，生物信息学和系统分析）专业知识的新教师来加强UMMC的心肾和代谢疾病研究。

DESCRIPTION (provided by applicant): Cardiovascular, renal and metabolic diseases are inextricably linked and are the leading causes of mortality and morbidity in the United States, especially in Mississippi which has the highest prevalence in the nation of these diseases. These disorders usually cluster together and are highly interdependent. Obesity and associated metabolic disorders, such as diabetes, are major causes of cardiovascular and renal disease. Abnormal kidney function is an important cause as well as a consequence of hypertension, a key risk factor for cardiovascular diseases such coronary artery disease and stroke. Understanding the complex relationships among cardiovascular, renal, and metabolic disorders and developing new therapeutic approaches requires a paradigm shift in research that incorporates multidisciplinary integrated approaches, combining the efforts of basic, clinical and population scientists. A major objective of this proposal is to develop an internationally recognized Cardiorenal and Metabolic Diseases Research Center (CMDRC) that brings together a multidisciplinary group of basic, clinical and population scientists working on a common synergistic theme, and to facilitate their collaborations. The specific aims are: 1) To develop infrastructure and core facilities that foster excellence in basic, clinical, and population research in cardiorenal and metabolic diseases and increase competitiveness of junior investigators for independent funding from NIH and other national biomedical research programs.; 2) To develop mentoring and education programs and research support for promising junior investigators so that they can become productive, independent investigators who can successfully compete for NIH funding; 3) To achieve the specific aims of the research projects described by the junior investigators in this proposal, and to foster their career development; 4) To develop a pipeline of diverse predoctoral graduate students, medical students and postdoctoral fellows trained in cutting edge cardiorenal and metabolic diseases research so they become the next generation of researchers in this field; major emphasis will be placed on recruiting and mentoring underrepresented minority investigators through partnerships with local minority institutions; 5) To enhance collaborations and interactions among established investigators from multiple disciplines in cardiorenal and metabolic diseases at UMMC, as well as with external partners; 6) To strengthen cardiorenal and metabolic disease research at UMMC by recruiting new faculty with expertise in clinical and translational research and in emerging technologies, such as in vivo imaging, molecular genetics, bioinformatics, and systems analysis.